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Zinc gluconate oral disintegrating tablet and its preparation process

A technology of zinc gluconate and orally disintegrating tablets, which can be used in medical preparations containing active ingredients, pill delivery, metabolic diseases, etc., can solve the problems of heavy economic burden on patients, inconvenient portability of oral liquids and syrups, and high manufacturing costs

Active Publication Date: 2005-07-06
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral liquids and syrups are inconvenient to carry, relatively high manufacturing costs, and heavy economic burden on patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Prescription

[0034] 1. Raw material - zinc gluconate 25.0g;

[0035] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;

[0036] 3. Filling agent - mannitol 45.5g;

[0037] Lactose 15.0g;

[0038] 4. Flavoring agent - aspartame 1.0g;

[0039] Orange essence 5.0g;

[0040] 5. Disintegrant—cross-linked polyvinylpyrrolidone 3.0g;

[0041] Croscarmellose 3.0g;

[0042] 6. Glidant—micronized silica gel 1.0g;

[0043] 7. Lubricant—magnesium stearate 1.0g.

[0044] The total weight is 100.0g, and a total of 1000 pieces are made.

[0045] (2) Preparation method

[0046] 1) Dissolve polyvinylpyrrolidone K-30 with 50% ethanol and dilute to a certain concentration for later use;

[0047] 2) Take zinc gluconate and lactose and use a high-speed mixing and stirring granulator to granulate, use the solution in step 1) as a binder, and dry it for subsequent use;

[0048] 3) Mix mannitol, micropowder silica gel, cross-linked polyvinylpyrro...

Embodiment 2

[0052] (1) Prescription

[0053] 1. Raw material - zinc gluconate 50.0g;

[0054] 2. Coating material - Eudragit  E100 10.0g;

[0055] 3. Filling agent - polysaccharide 71.0g;

[0056] 4. Flavoring agent - aspartame 1.0g;

[0057] Orange essence 2.0g;

[0058] 5. Disintegrant—cross-linked polyvinylpyrrolidone 7.0g;

[0059] Low-substituted hydroxypropyl methylcellulose 5.0g;

[0060] 6. Glidant—micronized silica gel 2.5g;

[0061] 7. Lubricant—magnesium stearate 1.5g.

[0062] The total weight is 150.0g, and a total of 1000 pieces are made.

[0063] (2) Preparation method

[0064] 1) Take Eudragit  Dissolve E100 with 95% ethanol and dilute to a certain concentration for later use;

[0065] 2) Take zinc gluconate and place it in a fluidized bed to boil, spray the above-mentioned solution at a certain speed for powder coating to obtain zinc gluconate powder-coated granules, dry and set aside;

[0066] 3) Mix the polymerized sugar, micropowder ...

Embodiment 3

[0070] (1) Prescription

[0071] 1. Raw material - zinc gluconate 70.0g;

[0072] 2. Adhesive - polyvinylpyrrolidone K-30 1.0g;

[0073] 3. Effervescent agent - citric acid 25.0g;

[0074] Sodium bicarbonate 20.0g;

[0075] 4. Filling agent - mannitol 102.5g;

[0076] PROSOLV  SMCC 10.0g;

[0077] 5. Flavoring agent - aspartame 1.5g;

[0078] Orange essence 4.0g;

[0079] 6. Disintegrant—cross-linked polyvinylpyrrolidone 8.0g;

[0080] AC carboxymethyl cellulose 4.0g;

[0081] 7. Glidant—micronized silica gel 2.0g;

[0082] 8. Lubricant—sodium stearyl fumarate 2.0g.

[0083] The total weight is 250g, and a total of 1000 pieces are made.

[0084] (2) Preparation method

[0085] 1) Mix zinc gluconate and citric acid raw materials and pulverize them, granulate with polyvinylpyrrolidone K-30, pass through a 26-mesh sieve, and set aside;

[0086] 2) Take sodium bicarbonate and pulverize it, granulate it with polyvinylpyr...

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Abstract

The invention discloses a zinc gluconate orally disintegrating tablet for prevention and treatment of developmental retardation, undernourishment, apocleisis, ulcerative stomatitis, and skin acne, and its preparation. The tablet is prepared by using zinc gluconate as raw material, using bulking agent, crumbling agent, flavoring agent, flow aid, and lubricating agent as adjuvant, using bonding agent or dressing material based on specific situation, or charging right amount of effervescent agent, then using specific preparing procedure and employing a tablet compressing machine for pelleting. The tablet can be taken under the condition of waterless, it has the advantages of fast effect, improved compliance for the patients, and increased curative effect of the medicament.

Description

technical field [0001] The invention relates to a zinc gluconate orally disintegrating tablet for preventing and treating growth retardation, malnutrition, anorexia, recurrent oral ulcers, skin acne, etc. caused by zinc deficiency in children, the elderly, and pregnant women. Its preparation process. Background technique [0002] Zinc participates in the synthesis and activation of various enzymes, plays an important physiological role in protein and nucleic acid synthesis, intestinal protein absorption and digestion, and promotes growth and development; by participating in the synthesis of taste hormones in taste buds and preventing buccal epithelial cell parakeratosis , maintain normal appetite and taste; enhance the phagocytic ability of phagocytic cells, intensify their vitality and bactericidal function; and maintain the level of free radicals in phagocytic cells through superoxide dismutase, free radicals can destroy the cell membrane of microorganisms, play a bacteric...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/192A61P3/02
Inventor 蒋海松王红喜王锦刚
Owner COSCI MED TECH CO LTD
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