70 results about "Diosmin" patented technology

The Diosmin producing process includes the following steps: adding high boiling point solvent into hesperidin, vacuum self distillation to eliminate crystal water from hesperidin, adding reaction solvent in the amount of 3-20 times weight of hesperidin and iodine in 0.3-0.6 time to react at 80-120 deg.c for 8-20 hr, vacuum concentrating, adding water solution of alkali and hydrolyzing at 30-80 deg.c for 1-8 hr, regulating pH value with dilute acid solution to acidity, filtering to obtain solid, water washing to neutrality, and drying to obtain Diosmin product. The process has low cost, high product purity and environment friendship.

The invention discloses a green and economical preparation method of diosmin, which comprises three steps of preparation, recovery and refining. Compared with the existing methods, the present invention completely avoids the use of pyridine and inorganic bases, the production environment is greatly improved, the aftertreatment is simple, elemental iodine and solvents can be recycled, the reaction conditions are mild, and the production cost is low. At the same time, the present invention The invention does not follow the classic method of alkali dissolution and acid precipitation to refine the crude product, but adopts the method of precipitating diosmin salt to refine the crude product, so that the purity of the finished product can reach 99%, the product quality is improved, and the operation is simple, which is suitable for industrial production.

Relating to drug preparation, the invention discloses a preparation method of diosmin. The method comprises the steps of: (1) adding hesperidin into a mixed solvent of pyridine and dimethyl sulfoxide, then adding potassium iodide and sulfuric acid to carry out dehydrogenation reaction to obtain a reaction intermediate product; (2) adding a sodium hydroxide-containing methanol solution into the reaction intermediate product to react; and (3) then adding acid to adjust the pH value, and conducting standing crystallization, thus obtaining diosmin. Compared with existing preparation methods, the preparation method provided by the invention has the characteristics of low cost, simple process and high product purity, and is suitable for industrial mass production.

A food composition for functional foods and nutritional supplements is for preventing, reducing or treating cardiovascular diseases or mild manifestations thereof, obtained from the combination of extracts derived from citrus species, which contain between 25 and 80% by weight of hesperidin; between and 10% by weight of isonaringin; between 0.5 and 1% by weight of eriocitrin; and between 0.1 and 1% by weight of diosmin and the use of the composition in functional foods and nutritional supplements.

The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation / phosphorylation of STAT3 induced by IL-6 in cultured neuronal cells. Furthermore, mice treated with diosmin showed a significant reduction of autistic phenotype induced by IL-6 through inhibition of STAT3 activation.

The present invention features a novel, low side-effect pharmaceutical compound complex, comprising the pharmaceutically effective dose of isoniazid (INH) and pharmaceutically effective dose of one of the following compounds. Said compound was selected from the following groups of compounds: Nordihydroguaiaretic acid, Trans-Cinnamaldehyde, Daidzein, Isovitexin, Kaempferol, disulfuram, β-Myrcene, Quercetin, (−)-Epigallocatechin-3-gallate, (+)-Limonene, Myricetin, Quercitrin, Luteolin-7-Glucoside, Morin, Neohesperidin, Hesperidin, Capillarisin, (−)-Epigallocatechin, Luteolin, Hyperoside, Ethyl Myristate, Tamarixetin, Phloretin, Baicalein, Rutin, Baicalin, Apigenin, Naringenin, Hesperetin, (+)-Epicatechin, (−)-Epicatechin-3-gallat, Isoliquritigenin, Silybin, Vitexin, Genistein, Isorhamnetin, gallic acid, Diosmin, 6-Gingerol, (+)-Taxifolin, Wongonin, Protocatechuic acid, (+)-Catechin, β-naphthoflavone, Embelin, Trans-Cinnamic acid, (−)-Epicatechin, Phloridzin, Puerarin, Umbelliferone, Brij 58, Brij 76, Brij 35, Tween 20, Tween 80, Tween 40, PEG 2000, PEG 400, Pluornic F68, and PEG 4000. The novel, low side-effect compound complex which contains pharmaceutically effective doses of isoniazid (INH), disulfuram (DSF) and / or a third compound, bis-nitrophenyl phosphate (BNPP) can reduce isoniazid (INH)-induced side effects, e.g. hepatotoxicity, etc.

The present invention relates to compositions comprising at least one flavonoid of natural or synthetic origin in association with melatonin for use to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumours, in particular for the treatment of tumours resistant to the chemotherapeutic agents currently in use. The at least one flavonoid is selected from the group comprising or, alternatively, consisting of rutin, oxerutin, diosmin and hesperidin, preferably rutin.