305 results about "Toxication" patented technology

Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed.

The invention relates to a new application of low molecular citrus pectin, in particular to the application of low molecular citrus pectin for treating and preventing lead and heavy metal poisoning in prepared medicines, foods and health care products. The low molecular citrus pectin is a compound prepared from soluble dietary fiber and galacturonic acid, the polysaccharide derivative is used as a metal ion absorbent (chelating agent), has absorption action on heavy metal ions, can remove heavy ions, such as Zn2+, Cu2+, Cd2+, Ag+, Cr3+, Ni2+, Hg2+, Pb2+ and the like. The low molecular citrus pectin is different from common chemical chelating agents; proved by animal and clinic experiments, lead, mercury and arsenic are discharged out of human bodies during toxin discharge, and the key level of calcium, magnesium, zinc or other minerals can not be influenced. The natural chelating function of the low molecular citrus pectin is a most ideal and successful solution for heavy metal pollution in the human body at present. Thus, the low molecular citrus pectin has the function of preventing various diseases and especially has special functions of clearing away harmful cells and discharging toxins in the human body.

The invention discloses a method for measuring blood concentration of paraquat. The method comprises the following steps of: (1) pretreating a sample, namely adding aqueous solution of an internal standard substance and a protein precipitation agent acetonitrile into a plasma sample, performing whirl mixing, centrifuging and sampling supernatant; (2) separating the sample, namely adopting a universal C18 liquid chromatographic column, and using an ion pairing agent in an acid mobile phase, wherein the acid mobile phase is mixed solution of 3mmol.L<-1> aqueous solution of sodium dodecyl sulfate, 0.2 percent of aqueous solution of trifluoroacetic acid, acetonitrile and water; and (3) detecting by using a diode array detector, namely detecting by using the diode array detector at a detectionwavelength of 250 to 260nm, measuring peak areas of the internal standard substance and the paraquat, and calculating the blood concentration of the paraquat through least square method linear regression. The plasma sample is easy and convenient to pretreat, the detection process is sensitive and rapid, toxic substances and the blood concentration thereof can be rapidly determined in actual application, and the method is high in clinical application value.

The invention discloses a method and device for selecting an optimal emergency evacuation route for a hazardous chemical enterprise. A leakage condition of a hazardous chemical enterprise and a jointdistribution probability of a wind farm are received, a real leakage scene set is constructed to carry out leakage simulation, gas concentrations of all preset monitoring points in all leakage scenesare recorded in real time, and a possible leakage diffusion region is determined; whether the gas concentrations of all to-be-evacuated sites in different leakage scenes reach a preset alarm thresholdis determined and the leakage scenes that may trigger alarming are used as evacuation scene sets of the to-be-evacuated sites; evaluation routes are determined and the evaluation routes connecting random route outlet points at accumulated boundaries of all possible leakage diffusion regions are selected from the determined evaluation routes to form a standby evaluation route set; and personnel toxication risks of all evacuation scenes of the standby evaluation routes are calculated to obtained an accumulated individual toxication risk, traversing of the standby evaluation route set is carriedout, and an optimal evacuation route is obtained by using a minimum accumulative individual toxication risk as an optimization function. Therefore, the blindness of the evacuation route selection iseffectively eliminated and the success rate of evacuation is greatly improved.

The present invention relates to a combination of a Neotyphodium species endophyte or endophyte culture in a symbiotic association with a host grass which association does not cause symptoms of toxicosis in animals through exclusion of ergovaline but, due to the inclusion of alkaloids including agroclavine, setoclavine or isosetoclavine, retains the ability to resist abiotic stresses and protect the grass from pests.

The invention relates to a benzimidazole zinc complex and a preparation method thereof. A chemical name of the benzimidazole zinc complex is dichloro-2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole zinc complex. The preparation method includes following steps: mixing 2-(carboxymethyl)benzoic acid with o-phenylenediamine, placing the mixture in phosphoric acid, performing a heating process at 180 DEG C for 3 hours to obtain a purple-green reactant, cooling the reactant to room temperature, adding distilled water, performing a neutralization reaction to obtain a yellow-green solid, performing a washing process through distilled water for three times, carrying out a filtering process, carrying out a recrystallization process through alcohol to obtain a yellow-green solid 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole, namely a ligand, dissolving ZnCl2 and the ligand 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole in a proper amount of a DMF solvent to obtain a mixture, stirring the mixture uniformly at room temperature, performing a volatilization process for seven days to obtain a slight yellow-green block-shaped complex monocrystal. The complex employs biological non-toxic element zinc as a metal ion, can be used for preparing antitumor drugs, can inhibit generation of esophagus cancer cells, and is free from remaining in human body and causing poisoning in human body due to metal accumulation. The complex is simple in the preparation method, is high in yield, is low in cost and is suitable for an industrial production.

The invention relates to a method for preparing a tetrodotoxin-degrading substance from a tetrodotoxin-producing bacteria fermentation broth, and a preparation and detection method of an extract liquid. The method comprises a method for artificially causing plasmid loss, a tetrodotoxin-degrading substance extraction method, and a tetrodotoxin degradation detection method. According to the invention, for a first time, the existence of a tetrodotoxin-degrading substance in aeromonas molluscorum is found, and an extraction method of the substance is established. The method has certain potential to be used in large-scale productions of the tetrodotoxin-degrading substance. The extract of the bacteria fermentation broth has a tetrodotoxin-degrading effect, and can be used for preparing medicines used for treating tetrodotoxin intoxication. Also, a raw material can be provided for related fields such as scientific research and pharmaceutical industries.

The invention relates to a lignin compound that could prevent yellow staphylococcal bacteria and B type hemolytic streptococcus, and the medicine combination of the compound. The invention of lignin Morgan dandehon herb acid A and Rufescidride has obviously effect restraining yellow staphylococcal and B type hemolytic streptococcus. It is also respected to prevent the diseases caused by them, like boil, blain, toxicity epidermis necrolysis, pneumonia, etc.

The invention provides salt containing carotene and iodine and a processing method thereof for solving the technical problems, so that people can get vitamin A conveniently. The salt containing the carotene and the iodine comprises the iodine, the salt and the carotene in a weight ratio of 20-60: 900,000-1,200,000: 1-500. The salt containing the carotene and the iodine is prepared by adding the carotene into the salt so as to provide a substance for people to take the carotene. The carotene, which is a precursor of the vitamin A, can be converted into the vitamin A according to the requirement of a human body under the catalysis of in vivo enzyme, without a poisoning phenomenon caused by the excessive intake of the vitamin A. The edible salt containing the carotene and the iodine is a new approach for supplementing the vitamin A.

The invention discloses a safe broad-spectrum povidone-iodine preparation and a preparation method and application thereof. Each 1000g of the safe broad-spectrum povidone-iodine preparation is prepared from 10 to 15.5g of polyvinylpyrrolidone, 5.5 to 7.5g of refined iodine, 1.8 to 8.3g of potassium iodide, 0.01 to 3g of potassium iodate, 0.01 to 1.25g of a surfactant, 2 to 8g of a pH regulator andthe balance of water. A weight ratio of the polyvinylpyrrolidone to the effective iodine is (1.6-3.6): 1. The safe broad-spectrum povidone-iodine preparation with a proper dosage cannot cause poisoning and digestive tract injury after being orally taken, can be used for preventing and treating diseases of animals, reducing antibiotic abuse and improving human food safety, and is good in stability, not easy to decompose under the illumination condition and long in preservation time.

The invention discloses detoxication engineering bacteria, and a preparation method and application thereof. The invention provides a recombinant plasmid which is obtained by introducing coded genes of detoxication esterase and coded genes of hydrolase into an enzyme cutting site in plasmid pETDuet-1. The engineering bacteria of the invention can be obtained by introducing the recombinant plasmidinto host bacteria. The engineering bacteria comprise the coded genes of the detoxication esterase and the hydrolase and can realize inducible expression of the detoxication esterase and the hydrolase. Crude enzyme solution obtained by fermentation of the engineering bacteria can also be protected. The engineering bacteria and the crude enzyme solution thereof can simultaneously degrade organic acid esters such as malathion, parathion, high-efficiency cypermethrin, acetofenate and the like and organophosphorus pesticides, and can be used for detoxication of organophosphorus poisoned warm-blooded animals. The invention provides a new way for biological pollution treatment of toxic and harmful compounds such as pesticides remained in water sources, soil and the like by using natural resources of eukaryote and prokaryote.

A composite medicine in the form of particles for preventing and treating lead poisoning is prepared from wolfberry fruit, galangal fruit, roasted oyster shell and taurine. Its advantages are high curative effect and no toxic by-effect.

The invention provides Ivermectin mixed micelle injection for reducing poisoning incidence and local reaction probability during the killing of livestock parasites and a preparation method thereof. The micelle injection is prepared by taking Ivermectin as active ingredients and adopting a cholate/phosphatide mixed micelle system, so the problem that the Ivermectin is difficult to dissolve in water is solved effectively, the medicine-carrying dose of the micelle injection is improved greatly. The mixed micelle injection prepared by the method has a simple preparation process, and can reduce the probability of toxic and side reactions during the killing of the livestock parasites.

The invention discloses an IgY antibody for resisting botulinus toxin substrate peptide, which can be prepared by the following steps: preparing SNAP25 short peptide subA by a chemical synthesis method or a gene recombination expression method; collecting eggs by subA immune laying chicken and extracting and purifying yelk immunoglobulin by a biochemical method. The antibody has the characteristics of high specificity of combining substrate linear short peptide subA, but not combining integral substrate SNAP25, has the capability of especially identifying zymolytic SNAP25 of A botulinus toxin,can be used as a detection reagent to be applied to the detection of the A botulinus toxin and the activity analysis of neurovirulence or endopeptidase as well as the poisoning diagnosis of clinicalkreotoxism, and has good market prospect and social significance.

The invention discloses a deslagging method for continuous production of methyl isocyanate. The method comprises the following steps: installing a deslagging machine below an air and liquid separator; performing air and liquid separation on a methyl isocyanate solution obtained by reaction by using the air and liquid separator; condensing a gas phase component and then rectifying and purifying to obtain a methyl isocyanate product; putting a liquid phase component in the deslagging machine and automatically removing tripolymethyl isocyanate solid slags; and returning the rest unreacted methyl carbamyl chloride, a trichloromethane solvent and a small amount of the methyl isocyanate product to a liquid mixing tank from the outlet of the deslagging machine and further reacting. The method disclosed by the invention can be used for automatically removing solid slags generated in the continuous production of the methyl isocyanate, realizing integration of deslagging and dry-recycle by adopting the deslagging machine, completely preventing direct contact between toxic materials and a person, reducing the labor strength, reducing toxication accidents, effectively evaporating residual volatile components such as raw materials, products and solvents in the solid slags and increasing the total yield of the products and the recycle rate of the solvents.