65 results about "Powder Aerosol" patented technology

A powder for inhalatory aerosol delivery, the powder having: spray freeze dried liposome particles with a biologically active agent, such as an antibiotic, encapsulated within a phospholipid, and a method of producing a powder for inhalatory aerosol delivery, the method including the steps of: mixing a biologically active agent with a phospholipid to form a liquid liposome suspension; and spray freeze drying the liposome suspension to form particles of powder.

A delivery device for a medicament including: a housing, a receptacle holding a medicament in the form of a power; and a source of propellant, wherein the housing provides an inlet and an outlet for the receptacle, wherein the inlet is in fluid communication with the source of propellant and is directed against the medicament and the outlet is spaced from the medicament to allow aerosolization of the medicament; the device provides improved delivery efficiency, particularly a delivered fine particle fraction of greater than 20% by weight.

A delivery device for a medicament including: a housing, a receptacle holding a medicament in the form of a power; and a source of propellant, wherein the housing provides an inlet and an outlet for the receptacle, wherein the inlet is in fluid communication with the source of propellant and is directed against the medicament and the outlet is spaced from the medicament to allow aerosolization of the medicament; the device provides improved delivery efficiency, particularly a delivered fine particle fraction of greater than 20% by weight.

A method and an apparatus are described for generating a concentrated aerosol. A first heated volume flow of pressurized gas, a second volume flow of pre not heated dilution gas, and a third volume flow of fluid are provided. After creating a droplet aerosol from a solution, the aerosol solvent is quickly evaporated for creating a powder aerosol that then concentrated with a virtual impactor. The apparatus comprises a low flow resistance and achieves a high evaporation rate. The apparatus comprises a flow conditioner, nozzle, nozzle holder, and a concentrator.

The invention discloses application of oridonin powder aerosol in treatment of acute lung injury. The oridonin powder aerosol is prepared by an oridonin nano-drug delivery system, wherein the dosage form of the nano-drug delivery system is selected from lipidosome, nanoparticles, nanosuspension, nanoemulsion and micro-emulsion. The medicines in the oridonin powder aerosol are stable, easily enter the deep parts of lung tissues, are positioned in a targeted mode and are convenient to carry and use, and the treatment of acute lung injury is promoted. The oridonin powder aerosol is used for treating the acute lung injury caused by infection, shock, smoking, trauma, toxin poisoning, inhalation of irritant gases, radiation, high oxygen and low oxygen, wherein the inhaled irritant gases comprise phosgene, diphosgene, triphosgene, chlorine, nitric oxides, formaldehyde, dimethyl sulfate, hydrogen chloride, hydrogen bromide, hydrogen fluoride, ammonia, ozone and sulfur dioxide.

The invention discloses a budesonide and formoterol spray inhalation suspension and a preparation method thereof.The budesonide and formoterol spray inhalation suspension comprises, per 1000 ml, the following components: 0.5-5 g of budesonide, 10-100 mg of formoterol, 0.1-0.5 g of a dispersant, 1-100 g of isoosmotic adjusting agent, 0.1-1 g of metal ion complexing agent, 0.1-20 g of pH buffer, pH regulator to adjust pH of a system to 4.0-6.0, and the balance of water, adding up to 1000 ml.The potential hazard of a lactose vector in powder aerosols can be avoided, delivery dosage is accurate and controllable, the requirement on ventilation flow is low, and compliance is good; the preparation method is simple to perform, required equipment is simple, and the requirement for asepsis of products can be met.

This invention supplies a drug composition used to cure asthma, bronchitis, chronic obstructive pulmonary disease, and other respiratory diseases. The drug contains two active constituents: gingko-leaf extract and epinephrine receptor stimulator. In experiment we get a unexpected effect: the gingko-leaf extract engenders notable synergism effect withª‰-epinephrine receptor stimulator, and this has crucial meaning to clinical therapy of asthma, bronchitis, chronic obstructive pulmonary disease. Compound preparation types of aerosol, spray, powder aerosol, capsule, slow release capsule, soft capsule, common tablet, slow release tablet, disperse tablet, buccal tablet, droplet, and so on are not only propitious to quickly exert drug curative effect, but also are convenient to take.

The present invention relates to an apparatus for manufacturing an inorganic thin-film solar cell, the apparatus including: a substrate stage which is mounted in a chamber and in which a solar cell substrate is disposed; and an inorganic powder supply unit including a nozzle configured to discharge an inorganic powder aerosol containing an inorganic powder onto the substrate stage in a supersonic flow so as to form a solar cell layer on the solar cell substrate, and an inorganic powder supply portion configured to supply the inorganic powder aerosol to the nozzle.

A delivery device (10, 110, 300, 500) for a medicament includes: a housing (50), or a main body (310, 505), a receptacle (54, 600) holding a medicament in the form of a powder; and a source of propellant (53, 305), wherein the housing (50), or the main body (310, 505) provides an inlet (63, 380) and an outlet (55, 370) for the receptacle (54, 600), wherein the inlet (63, 380) is in fluid communication with the source of propellant (53, 305) and is directed against the medicament and the outlet (55, 370) is spaced from the medicament to allow aerosolization of the medicament; the device provides improved delivery efficiency, particularly a delivered fine particle fraction of greater than 20% by weight.

A method and an apparatus are described for generating a concentrated aerosol. A first heated volume flow of pressurized gas, a second volume flow of preheated dilution gas, and a third volume flow of fluid are provided. After creating a droplet aerosol from a solution, the aerosol solvent is quickly evaporated for creating a powder aerosol that then concentrated with a virtual impactor. The apparatus comprises a low flow resistance and achieves a high evaporation rate. The apparatus comprises a flow conditioner, nozzle, nozzle holder, and a concentrator.

A denture fixative composition containing lower alkyl vinyl ether-maleic anhydride copolymers, water-insoluble and water-swelling polymers, and at least one additional adhesive material which can be used as a denture fixative paste, liquid, powder, aerosol, dissolving tablet, liner or adhesive-like strip.

The instant invention discloses a method of generating silicon powder aerosol to maintain cleanliness of the silicon powder during the feed process which utilizes an carrier gas, optionally, inert, and non-contaminating feed line to a plasma spray gun.

The invention belongs to the technical field of medicines, and discloses a xanthan gum-containing preparation which is used for preventing and treating tissue adhesion after a surgery. The main component of the preparation is xanthan gum; and other parting agents and pharmacologically active substances, such as anticoagulants, anti-inflammatory agents, calcium channel blockers, cell growth inhibitors and proteolytic enzymes can be added into the main component to prepare a composite preparation for use; and the form can be gels, powder aerosols or film agents. The preparation disclosed by the invention has a significant effect on preventing the adhesion after the surgery, and has the advantages of good effect, stable quality, convenience in use and the like compared with other anti-blocking medicaments and blocking agents.

The invention discloses a calibration testing apparatus for a medicinal powder aerosol concentration sensor. The calibration testing apparatus comprises a medicinal powder atomization and homogenization cavity, a sensor testing unit, a control and display unit, a splitting plate and a guide plate, wherein the splitting plate and the guide plate are used for adjusting air flow; the control and display unit is used for setting, acquiring, displaying, adjusting and controlling parameters like flow velocity and pressure intensity of air flow in the apparatus, carrying out data operation and realizing cleaning of the apparatus; the medicinal powder atomization and homogenization cavity is used for accomplishing atomization of medicinal powder and rapid uniform mixing of medicinal powder aerosol; the state of medicinal powder aerosol in an output pipeline of a medical atomizer is simulated by using the sensor testing unit; and with the concentration, flow velocity and pressure intensity of the medicinal powder aerosol as variables, a to-be-calibrated sensor is calibrated. The standard medicinal powder aerosol prepared in the invention has good uniformity and stability, can be used for calibration testing of a plurality of influencing parameters of the to-be-calibrated sensor and improves accuracy of calibration of the medicinal powder aerosol concentration sensor.

The invention discloses a tester of inflammability of foamed aerosol, comprising an ignition source applying mechanism, a flame detecting mechanism and a platform. An electric cabinet is installed at one end of the platform and the flame detecting mechanism is fixed at the other end of the platform. The ignition source applying mechanism is installed between the electric cabinet and the flame detecting mechanism. The tester has high degree of detection automation, realizes automatic ignition and detection of the samples, can detect the flame intensity and the duration and fill up the blank in the domestic technology of detecting the foamed aerosol; the tester has wide applicable range and realizes detecting various foamed aerosol, such as the foamed aerosol, pasty aerosol, powdered aerosol, liquid aerosol and the like; the tester adopts the automatic detection device, is fast in detection, can continuously work and is strong in safety in the detection process; and the tester has high detection accuracy and overcomes the detect that the traditional artificial detection height and duration are incorrect.

The invention discloses application of chlorogenic acid to preparing medicine for treating allergic rhinitis. The chlorogenic acid can be used for preparing compositions in diversified forms. The compositions include oral, injection and lung inhalation preparations and particularly include injection, oral liquid, tablets, capsules, granules, aerosol, powder aerosol and spray.

Belonging to the fields of pharmacology and pharmaceutics, the invention relates to an ambroxol powder aerosol, its preparation method and application. Specifically, the ambroxol powder aerosol contains ambroxol and / or a medicinal salt thereof, as well as a pharmaceutically acceptable auxiliary material. The ambroxol powder aerosol is characterized by having an aerodynamic particle size greater than 5 micrometers and less than or equal to 15 micrometers. The ambroxol powder aerosol of the invention can target a lesion part (a trachea and / or a bronchus). In addition, the preparation method prepared in the invention greatly reduces the material loss in production, and has the advantages of cost saving, simple process, as well as easy implementation.

The invention relates to a powder aerosol moving type oro-nasal inhalation and contamination device which comprises an exposure chamber, an experimental animal fixator, an air compressor, a powder diffuser, a diffusion airflow pipe, a vibration device, a powder aerosol sample injection pipe, a hedging type blending chamber, a hedging dilution airflow pipe, a fan and a microprocessor control unit. The powder diffuser is used for solving the problem of quantitative spraying and diffusion of solid test substance powder; the powder diffuser is connected with the hedging type blending chamber through the powder aerosol sample injection pipe, the hedging type blending chamber is fixed to the top of the exposure chamber and communicated with the inside of the exposure chamber, the exposure chamber is provided with an exposure chamber port, the front end of the experimental animal fixator is connected with the exposure chamber through the exposure chamber port, and the microprocessor control unit is used for regulating operating parameters of the contamination device. The powder aerosol moving type oro-nasal inhalation and contamination device simulates a powder aerosol exposure mode in an actual environment, the concentration of test substances is distributed evenly, an exposure state is stable, experimental result repeatability is good, and the powder aerosol moving type oro-nasal inhalation and contamination device is fast and convenient to operate and wide in applied range.

The invention discloses a fire detection tube type powder aerosol self-extinguishing device. A composite pressure tank consists of an outer barrel in which high-pressure driving gas is stored and an inverted conical inner barrel which is positioned in the outer barrel and is used for storing a powdery fire extinguishing agent and the driving gas; a constant pressure self-locking one-way valve through which the high-pressure driving gas in the outer barrel enters the inner barrel is arranged on a barrel body of the inner barrel which corresponds to the outer barrel; a bottle head valve is arranged on the top of the inner barrel; the bottom end of a siphon pipe connected to the bottle head valve stretches into the bottom of the inner barrel; a ball valve and a polymer hose which is connected to an outlet of the ball valve and is used for filling the driving gas are arranged on the top of the bottle head valve; an inflating one-way valve and a pressure alarm switch are arranged at the tail end of the polymer hose; an electric signal output by the pressure alarm switch is connected to an alarm display. According to the fire detection tube type powder aerosol self-extinguishing device disclosed by the invention, reliable fire extinguishing pressure in the inner barrel can be kept by the outer barrel through the constant pressure self-locking one-way valve, and the driving gas in the outer barrel and the fire extinguishing agent and the driving gas in the inner barrel are totally released together during a fire.

The spraying agent has recipe comprising nine kinds of Chinese medicinal materials including honeysuckle, cordate houttuynia, dried orange peel, lily, reed rhizome, etc. The preparation process of the spraying agent includes preparing material powder, ultrasonic cell wall breaking, water vapor reflux decoction to extract active components, concentrating medicine liquid in decompression rotating evaporating instrument and spray drying. The spraying agent is used in preventing and treating respiratory system diseases.

The invention discloses a calibration method for a medicine powder aerosol concentration sensor. In the cleaning process, water and impurities in a device are removed, so that accurate preparation of medicine powder aerosol is guaranteed; in the preparation process of the medicine powder aerosol, standard-concentration medicine powder aerosol is obtained; a double closed-loop fuzzy control algorithm is used for controlling airflow speed and pressure intensity so that accuracy and stability of airflow speed and pressure intensity adjustment can be guaranteed; in the process of calibrating the sensor, in consideration of influences on performance of the medicine powder aerosol concentration sensor to be calibrated by the medicine powder aerosol concentration, the airflow speed and the pressure intensity, various influence parameters of the medicine powder aerosol concentration sensor are calibrated through a concentration influence calibration test, a flow speed influence calibration test and a pressure intensity influence calibration test. The calibration method for the medicine powder aerosol concentration sensor improves the calibration accuracy and comprehensiveness of the sensor, and can effectively reduce calibration errors of the medicine powder aerosol concentration sensor.

A method of making aggregate particles suitable for a powder aerosol composition that includes forming a dispersion of nanoparticulate drug and / or excipient in a non-aqueous liquid, and spray-drying the dispersion to generate aggregate particles having a mass median aerodynamic diameter of less than or equal to about 100 microns, and particles generated by such method, and compositions of said particles.

A denture fixative composition containing lower alkyl vinyl ether-maleic anhydride copolymers, water-insoluble and water-swelling polymers, and at least one additional adhesive material which can be used as a denture fixative paste, liquid, powder, aerosol, dissolving tablet, liner or adhesive-like strip.

The invention discloses a method for preparing an aztreonam (AZT) powder aerosol. The method comprises the following steps: accurately weighing a certain quantity of AZT or AZT and auxiliary materials; dissolving the weighed AZT or AZT and auxiliary materials in an appropriate solvent to obtain a basic solution; spray-drying the basic solution to manufacture corresponding dry powder particles, wherein the auxiliary material is amino acid and / or an absorption enhancing agent. According to the method, the particle diameters of the prepared AZT dry powder particles are within the inhalable range, so that favorable dispersity and efficient lung delivery efficiency are achieved.

The invention discloses a pearl powder aerosol. A pearl powder emulsion is stored in an aerosol can in an isolated mode by virtue of a bag, and propellant is filled between the aerosol can and the bag, wherein the pearl powder emulsion consists of the following components in percentage by weight: 4.0-5.0% of pearl powder, 2.0-3.0% of isopropyl myristate, 0.01-0.02% of silica, 12-14% of cyclopentasiloxane and the balance of de-ionized water. The pearl powder emulsion, as a content, is uniformly released and sprayed in a delicate and soft atomized form, so that the pearl powder aerosol can better condition skin. The pearl powder aerosol disclosed by the invention is more rapid and efficient to use, convenient to carry and easy for storage; and by virtue of a light-tight container (the aerosol can), the pearl powder emulsion is isolated from a light source and air, so that the preservation time of the pearl powder emulsion is prolonged.

The present invention relates to an apparatus for manufacturing an inorganic thin-film solar cell, the apparatus including: a substrate stage which is mounted in a chamber and in which a solar cell substrate is disposed; and an inorganic powder supply unit including a nozzle configured to discharge an inorganic powder aerosol containing an inorganic powder onto the substrate stage in a supersonic flow so as to form a solar cell layer on the solar cell substrate, and an inorganic powder supply portion configured to supply the inorganic powder aerosol to the nozzle.

The invention provides new use of zoledronic acid and a novel dosage form for inhalation administration. The zoledronic acid for inhalation administration can be in the form of powder aerosol and atomized droplets, and is characterized in that the granularity is less than or equal to 7mu m; the zoledronic acid can include or not include any auxiliary material. The zoledronic acid for inhalation administration can directly promote airway relaxation, resisting inflammation and improving pathology on the respiratory tract, can be used for treating chronic obstructive pulmonary diseases and / or asthma, and can significantly improve the pulmonary function of mice suffering from chronic obstructive pulmonary diseases, reduce the airway resistance by about 50 percent, and enhance the pulmonary dynamic compliance by about 50 percent.

The invention relates to a powder aerosol generator for preventing a low-fluidity drug from caking. The powder aerosol generator comprises a rapping device, a diffuser and a controller (6) and is characterized in that the rapping device comprises an electromagnet (1), a cover plate (2), offsetting springs (3) and a bracket (4); the cover plate (2) is a top plate of a toxicant exposure cabinet, and the electromagnet (1) is fixed on the cover plate (2) through a screw; the bracket (4) is fixed on the cover plate (2) through four threaded rods fitted with the bracket (4), and a vibrating shaft on the electromagnet (1) penetrates through circular holes in centers of the cover plate (2) and the bracket (4) and is stably connected with a sprayer (5); middles of the offsetting springs (3) are provided with stainless-steel shafts with threads in a penetrating manner, and the stainless-steel shafts penetrate through circular holes in the bracket (4) and are stably connected with the sprayer (5). According to the powder aerosol generator, the diffuser is used for regulating a spraying rhythm in a manner that the controller controls the frequency of opening of an electromagnetic valve, so that the aim of controlling the amount of the drug sprayed is achieved. Different sprayed drug amount outputs can be obtained through adjusting different control parameters, so that the problem in quantitative control on the drug sprayed is solved.

The invention relates to a powder aerosol capable of resisting to idiopathic pulmonary fibrosis and a preparation method thereof, and belongs to the field of medicinal preparations. The powder aerosol includes, by weight in parts, 80-95 parts of active pharmaceutical ingredients, 2.5-20 parts of an endogenous pulmonary surfactant, and 0-10 parts of calcium salt. The particle volume geometric diameter of the powder aerosol is 0.5-6 [mu]m. The powder aerosol has a less and narrow geometric diameter distribution, so that the powder aerosol can directly reach the lesion. A lung deposition rate FPF value is greater than 50%. An FPF value (3.4) is greater than 30%, which refers to a deep lung deposition pattern. The powder aerosol can be delivered to the depth of the lung to achieve a clinical effect of anti-pulmonary fibrosis; the dosage of active ingredients of drugs can be reduced; and therefore, adverse reactions caused by the increasing of the dosage of the active ingredients can be reduced to a greater extent.

The invention discloses a pharmaceutical composition comprising olodaterol or pharmaceutically acceptable salts thereof and ciclesonide. The composition can be prepared into respirable spray, aerosol or powder aerosols. The pharmaceutical composition has a synergistic effect, can reduce adverse reactions, is an ideal measure for rapidly relieving asthma and various COPD acute attacks, is an important treatment means of avoiding bronchial spasm and improving anoxia and is easy and convenient to operate, safe and reliable.