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Xanthan gum-containing anti-blocking preparation

A xanthan gum and anti-adhesion technology, applied in the field of medicine, can solve the problems of limited anti-tissue adhesion, insufficient molecular weight, short retention time, etc., and achieve the effect of prevention and treatment of adhesion, long retention time and remarkable effect

Inactive Publication Date: 2013-09-11
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are still some shortcomings in the clinical use of hyaluronic acid, such as the molecular weight is not large enough, the concentration is low, and the residence time in the body is short.
However, because hyaluronic acid is easily decomposed and absorbed in the body, the anti-tissue adhesion effect is limited

Method used

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  • Xanthan gum-containing anti-blocking preparation
  • Xanthan gum-containing anti-blocking preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: The gel agent in the present invention, in 100 milliliters, takes 3 grams of xanthan gum, adds appropriate amount of physiological saline to swell for subsequent use, gets 10 grams of dextran, 0.1 gram of dexamethasone sodium phosphate, after adding appropriate amount of water to dissolve, and The above-mentioned xanthan gum swelling solution is mixed, replenished to volume, and stirred at a high speed to obtain the compound gel of the present invention.

Embodiment 2

[0014] Embodiment 2: the powder aerosol of the present invention, in 100 grams, takes 60 grams of xanthan gum and 40 grams of dextran, mixes and seals, and sterilizes with ethylene oxide or microwave to obtain the present invention. Powder mist.

Embodiment 3

[0015] Embodiment three: powder mist in the present invention, in 100 grams, get 10 grams of xanthan gum, 0.1 gram of dexamethasone sodium phosphate, all the other are dextran, after each with ethylene oxide or microwave sterilization, mix in proportion Pack evenly to obtain the powder spray of the present invention.

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Abstract

The invention belongs to the technical field of medicines, and discloses a xanthan gum-containing preparation which is used for preventing and treating tissue adhesion after a surgery. The main component of the preparation is xanthan gum; and other parting agents and pharmacologically active substances, such as anticoagulants, anti-inflammatory agents, calcium channel blockers, cell growth inhibitors and proteolytic enzymes can be added into the main component to prepare a composite preparation for use; and the form can be gels, powder aerosols or film agents. The preparation disclosed by the invention has a significant effect on preventing the adhesion after the surgery, and has the advantages of good effect, stable quality, convenience in use and the like compared with other anti-blocking medicaments and blocking agents.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation containing xanthan gum for preventing and treating tissue adhesion after surgery. Background technique [0002] Adhesions often occur after abdominal, gynecological, orthopedic, cardiothoracic and orthopedic surgery, and can lead to serious clinical complications, such as intestinal obstruction, abdominal and pelvic pain, infertility, etc., increasing the difficulty of reoperation, and may occur further complications. The purpose of preventing adhesions is to eliminate or reduce the severity or scope of adhesions, thereby preventing the occurrence of complications caused by adhesions. The anti-adhesion measures currently adopted are mainly through improving surgical skills and using auxiliary agents. Although they can prevent postoperative adhesions, the effect is not certain. Hyaluronic acid is an effective drug for preventing postoperative adhesions and is widely...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/723A61P41/00
Inventor 凌沛学邵华荣窦茜茜宋志刚韩冠英王桂兰赵丽娟朱希强刘飞
Owner 凌沛学
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