70 results about "Ciclesonide" patented technology

The invention relates to pharmaceutical formulations containing combinations of ciclesonide and a syk inhibitor and the use of such pharmaceutical compositions in medicine, in particular in the prophylaxis and treatment of respiratory disease.

The present invention provides a ciclesonide-containing sterile aqueous suspension sterilized by autoclaving, wherein the concentration of ciclesonide after autoclaving is 95% or more compared to that before autoclaving, as well as methods of manufacturing a ciclesonide-containing sterile aqueous suspension comprising the step of sterilization by autoclaving a ciclesonide-containing aqueous suspension.

The present invention relates to a combination of ciclesonide with antihistamines.

The invention relates to the field of medicine, in particular to the field of veterinary medicine. The invention relates to glucocorticoids, especially ciclesonide or a pharmaceutically acceptable derivative or salt thereof, for the treatment of airway disease in horses, such as pulmonary disease, preferably recurrent airway obstruction (RAO), Summer Pasture Associated Obstructive Pulmonary disease (SPAOPD), and inflammatory airway disease (IAD).

The invention relates to the field of medicine, in particular to the field of veterinary medicine. The invention relates to a pharmaceutical (medicament) formulation of glucocorticoids, especially ciclesonide or a pharmaceutically acceptable derivative thereof.

Provided is a process for increasing the 22R/22S epidemic ratio of ciclesonide.

The invention relates to a novel 16,17-ketal intermediate for preparing ciclesonide, which discloses a compound of formula (III), a method for synthesizing the compound of formula (III) from a compound of formula (I), and a method for synthesizing ciclesonide from the compound of formula (III).

The invention discloses ciclesonide capsule type inhalation aerosol powder and a preparation method thereof. The ciclesonide capsule type inhalation aerosol powder can improve the deposition rate of ciclesonide in the inhalation aerosol powder in lung, avoid the deposition of carrier micropowder in the lung, improve the stability of a composition and consists of an active component and micropowder of a carrier and is characterized in that the average particle diameter of the micropowder as the active component is 0.5-10mu m and the average particle diameter of the micropowder of the carrier is 20-45mu m.

The invention relates to ciclesonide nanometer freeze-dried powder and a preparation method thereof and belongs to the technical field of medicinal preparation. The preparation method comprises the following steps: adding 2400-3900 weight parts of freeze-drying protecting agents into a ciclesonide nanometer grain colloidal solution, dissolving and filtering, and then pre-freezing and freeze-drying, thereby obtaining the ciclesonide freeze-dried powder, wherein the ciclesonide nanometer grain colloidal solution comprises 1 weight part of ciclesonide, 5.0-12 weight parts of carrier materials and 25-35 weight parts of hydrophilic surface active agents. The obtained ciclesonide nanometer freeze-dried powder is excellent in stability and solubility and high in safety and has the advantage of excellent appearance; after re-dissolving, the grain size of the solution is below 800nm and the medicine encapsulation efficiency is above 70%; and the technology provided by the invention has the advantages of simplicity and easiness in operation.

The invention relates to a ciclesonide nitrate derivative (I) shown in the specification, wherein X is -CO(O)a(CR4R5)b' D(CR4R5)b''-, a is 0 or 1, b' and b'' can be same or different and are integers from 0 to 6, R4 and R5 are same or different and are selected from H and hydrocarbon compounds with 1-6 carbons, D can be nonexistent and also can be a hydrocarbon compound with 1-8 carbons containing 0-2 heteroatoms, the heteroatom is one or two of N, O and S, and X and 21 hydroxyl groups of des-ciclesonide (des-CIC) are connected through ester bonds.

The invention discloses a synthesis method for ciclesonide with a structure shown as the formula (III). The synthesis method adopts 16 Alpha-hydroxyprednisolone as material with a structure shown as the formula (I) and acidic ionic liquid as solvent and catalyst with a structure shown as the formula (II), and includes the following specific steps that: the 16Alpha-hydroxyprednisolone, isobutyricanhydride, cyclohexanal and the acidic ionic liquid are added into a reaction container together, and react under the temperature condition of 10 DEG C to 100 DEG C, and after sufficient reaction, the obtained reaction liquid is postprocessed, so that the ciclesonide product is obtained. Since the invention adopts the acidic ionic liquid as solvent and catalyst and a one-pot method for preparation, the technique has the advantages of easy operation, high capacity, high efficiency, less three wastes and convenient postprocessing, the ionic liquid can be reused, and therefore the technique is an economic, practical and environment-friendly technique.

A pharmaceutical aerosol formulation comprising particles of formoterol or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, said particles being suspended in the formulation; a compound of the formula (I), in which: R₁ is 1-butyl, 2-butyl, cyclohexyl or phenyl and R₂ is acetyl or isobutanoyl, said compound of formula (I) being dissolved in the formulation; and a propellant selected from 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane and a mixture thereof.

The invention relates to an inhalant containing N-acetyl-L-cysteine and ciclesonide and preparation method thereof. The inhalant is composed of ciclesonide and N-acetyl-L-cysteine as the active ingredients, and one or more pharmaceutical adjuvants suitable for inhalation drug delivery.

The invention relates to a ciclesonide azelastine compound composition. The ciclesonide azelastinenasal spray composition contains (A) ciclesonide monohydrate, and (B) azelastine or salt thereof and a pharmaceutically acceptable carrier, wherein the ciclesonide monohydrate exists in a crystal form.

The invention provides a new synthetic route for preparation of ciclesonide. The method comprises the steps that used raw materials are cheaper and available, the reaction raw materials are protectedafter hydroxylation, selective oxidation of a five-membered ring double bond is then performed, then, a six-membered ring double bond bromination is conducted, bromine atom is removed by reduction, acarbonyl group and a hydroxyl protecting group are removed, then, an oxidized dihydroxyl group is protected, the six-membered ring double bond is then epoxidized and reacts with cyclohexanecarboxaldehyde and isobutyryl chloride in turn to obtain a ciclesonide product. A reaction process is easy to operate, yield is higher in each step, purity of the obtained product is also higher, generation of by-products is effectively avoided, production cost is reduced, and the new synthetic route for the preparation of the ciclesonide is advantageous to industrial production.