2900 results about "Methylene radical" patented technology

Based on the above and on the remarkable properties of the 2′-O,4′-C-methylene bridged LNA monomers it was decided to synthesise oligonucleotides comprising one or more 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer(s) as the first stereoisomer of LNA modified oligonucleotides. Modelling clearly indicated the xylo-LNA monomers to be locked in an N-type furanose conformation. Whereas the parent 2′-deoxy-β-D-xylofuranosyl nucleosides were shown to adopt mainly an N-type furanose conformation, the furanose ring of the 2′-deoxy-β-D-xylofuranosyl monomers present in xylo-DNA were shown by conformational analysis and computer modelling to prefer an S-type conformation thereby minimising steric repulsion between the nucleobase and the 3′-O-phopshate group (Seela, F.; Wömer, Rosemeyer, H. Helv. Chem. Acta 1994, 77, 883). As no report on the hybridisation properties and binding mode of xylo-configurated oligonucleotides in an RNA context was believed to exist, it was the aim to synthesise 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer and to study the thermal stability of oligonucleotides comprising this monomer. The results showed that fully modified or almost fully modified Xylo-LNA is useful for high-affinity targeting of complementary nucleic acids. When taking into consideration the inverted stereochemistry at C-3′ this is a surprising fact. It is likely that Xylo-LNA monomers, in a sequence context of Xylo-DNA monomers, should have an affinity-increasing effect.

A composition comprising a polymerizable compound of the formula (1) and a rod-shaped polymerizable liquid crystal compound: P2-E2-X2-B2-A2-(G2)t-Y-(G1)s-A1-B1-X1-E1-P1   (1) (in the formula (1), Y represents a di-valent group, s and t represent each independently an integer of 0 or 1, G1 and G2 when s and t are 1 represent each independently —CR1R2—, R1 and R2 represent each independently an alkyl group having 1 to 4 carbon atoms, halogen atom or hydrogen atom, A1 and A2 represent each independently a di-valent cyclic hydrocarbon group, di-valent heterocyclic group, methylenephenylene group, oxyphenylene group or thiophenylene group, B1 and B2 represent each independently a di-valent group, X1 and X2 represent each independently a di-valent group, E1 and E2 represent each independently an alkylene group having 2 to 25 carbon atoms, and P1 and P2 represent a hydrogen atom or polymerizable group, at least one of P1 and P2 being a polymerizable group.).

The present invention relates to a composition comprising a polyester, a copolyester ether and an oxidation catalyst, wherein the copolyester ether comprises a polyether segment comprising poly(tetramethylene-co-alkylene ether). The composition has oxygen scavenging properties and produces articles having low haze. Other embodiments of the present invention disclosed herein are articles made from the composition and methods to make such articles.

The invention is a continuous process for the preparation of polytrimethylene ether glycol from 1,3-propanediol reactant. In addition, the invention is directed to a continuous multi-stage process comprising reacting at least one reactant in a liquid phase in an up-flow column reactor, and forming a gas or vapor phase by-product wherein the gas or vapor phase by-product is continuously removed at the top and at least one intermediate stage.

Compounds of formula (I) Z-Ar1—Ar2  (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from an unsubstituted or substituted 5-membered heteroaryl ring; an unsubstituted or substituted 6-membered heteroaryl ring; 3,4-(methylenedioxy)phenyl; and phenyl substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

A luminescence device is principally constituted by a pair of electrodes and an organic compound layer disposed therebetween. The layer contains a metal coordination compound represented by the following formula (1): wherein M denotes Ir, Rh or Pd; n is 2 or 3; CyN denotes a substituted or unsubstituted cyclic group containing a nitrogen atom connected to M and capable of containing another nitrogen atom and / or a sulfur atom; and CyC denotes a substituted or unsubstituted cyclic group containing a carbon atom connected to M and capable of containing a nitrogen atom and / or a sulfur atom, CyN and CyC being connected to each other via a covalent bond, and each of substituents for CyN and CyC being selected from the group consisting of a halogen atom; nitro group; a trialkylsilyl group containing three linear or branched alkyl groups each independently having 1-8 carbon atoms; and a linear or branched alkyl group having 1-20 carbon atoms capable of including one or at least two non-neighboring methylene groups which can be replaced with -O-, -S-, -CO-, -CO-O-, -O-CO-, -CH=CH- or -C=C- and capable of including a hydrogen atom which can be replaced with a fluorine atom; with the proviso that a sum of nitrogen atom and sulfur atom present in ring structures of CyN and CyC is at least 2.

The present invention provides a compound of the formula:wherein Ar represents an aromatic group which may be substituted;X represents methylene, S, SO, SO2 or CO;Y represents a spacer having a main chain of 2 to 5 atoms;n represents an integer of 1 to 5;i) R1 and R2 each represents a hydrogen atom or a lower alkyl which may be substituted,ii) R1 and R2 form, taken together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring which may be substituted, oriii) R1 or R2 together with -(CH2)n-N= form, bonded to a component atom of Ring B, a spiro-ring which may be substituted;Ring A represents an aromatic ring which may be substituted;Ring B represents a 4- to 7-membered nitrogen-containing non-aromatic ring which may be further substituted by alkyl or acyl,with a proviso that X represents S, SO, SO2 or CO when Ring A has as a substituent a group represented by the formula:where R11 represents alkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or a group represented by the formula:where R12 represents alkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, or a salt thereof; which has an excellent somatostatin receptor binding inhibition action.

The invention discloses polyhexamethylene guanidine propionic acid and preparing method thereof. The preparing method employs stepwise synthesis, which includes steps of: sufficiently mixing dicyandiamide and alanine under high temperature to synthesize aminoguanidine propionic acid, mixing the aminoguanidine propionic acid, triethylidenepropyldiamine and initiator under high temperature to synthesize the polyhexamethylene guanidine propionic acid. Advantages of the invention are: sterilization effect is excellent, toxity is actually nontoxic level, effect of sterilization is better than existent technique, due to overcoming strong hygroscopicity in existence, the polyhexamethylene guanidine propionic acid can be produced to stable powder, thereby being widely used in fields such as weave, plastic, daily chemicals and water treatment.

A method preparing controlled release nitrogen in particulate fertilizers which exhibit single growing season availabilities to plants of about 80 percent or higher. The method utilizes relatively low urea and ammonia to formaldehyde mol ratios of about 1.7 urea to 0.1 ammonia to 1 formaldehyde to assure high conversions to controlled release nitrogen with low free ureas, and carefully controlled elevated temperatures, acid dehydration condensation catalyst concentrations and short dehydration reaction times of about 2-4 minutes to provide effective conversion of hydroxymethyl nitrogen compounds by dehydration condensation reaction to controlled release methylene nitrogen compounds. Quick neutralization of the dehydration catalyst in a turbulent mixing reactor minimizes the formation of undesirable methylene nitrogen polymers which are hot water insoluble and unavailable to plants in a single growing season.

A process for the manufacturing of a core forming a carrying structure for decorative laminates. The core comprises particles of cured, and optionally foamed, rigid, polyurethane, polyisocyanurate and / or phenolic resin. The particles are bonded to each other in a pressing procedure with a bonding agent comprising an adhesive such as a polymerizing monomer.i) The particles are achieved by grinding cured, and optionally foamed, rigid, polyurethane, polyisocyanurate and / or phenolic resin so that it passes through a 2 mm screen, preferably a 1 mm screen,ii) 100 parts per weight of particles is mixed with 1-100 parts per weight of fiber, the fiber additive having an average length in the range 1-15 mm.iii) The particle-fiber mixture is allowed to absorb a selected amount of water, the amount of water being in the range 1-15% by weight, The water is either added at any stage before the adding of bonding agent, and / or being used as a solvent in the bonding agent, and that,iv) 85 parts per weight of the particle mixture is mixed with 2-15 parts per weight of a bonding agent, the bonding agent selected from the group consisting of,a) A mixture of polyols, such as polyester or polyether, crude methylene diphenyl diisocyanate and possibly a small amount of blowing agent in a ratio forming a polymeric resin with a density in the range 600-1400 kg / m3.b) A formaldehyde based resin such as phenol-formaldehyde resin, urea-formaldehyde resin, melamine-urea-formaldehyde resin, melamine-urea-phenol-formaldehyde resin or phenol-resorcinol-formaldehyde resin, orc) Polyvinyl acetate resin.v)The mixture is applied between the belts of the continuos belt press or the press plates of a static press, optionally with at least one intermediate carrier web, the belts or press plates allowing a mainly uniform and specified material thickness to form. A slightly porous and preconditioned core with a selected water content in the range 0.8-12% is hereby achieved. The invention also relates to a decorative laminate achieved through the process.

A process for producing 2-acrylamide-2-methyl propane sulfonic acid (ATBS) which comprises reacting acrylonitrile, fuming sulfuric acid, and isobutylene. During the reaction, the concentration of 2-methyl-2-propenyl-1-sulfonic acid (IBSA) and / or that of 2-methylidene-1,3-propylenedisulfonic acid (IBDSA) in the reaction system are determined. When the IBSA concentration exceeds 12,000 mass ppm and / or the IBDSA concentration exceeds 6,000 mass ppm, then the concentration of sulfur trioxide in the reaction system is reduced. Thus, ATBS having an IBSA content of 100 mass ppm or lower and an IBDSA content of 100 mass ppm or lower is produced.

Saturated and unsaturated compounds having sweet, salt or umami taste enhancement qualities. The compounds have the structure: where R1═H or methyl; R2 is selected from the group consisting of H, C1-C4 alkyl, alkenyl and methylene; R3 is selected from the group consisting of H, C1-C8 straight or branched chain alkyl, alkenyl, dienalkyl or phenyl; or if R1═H, R2 and R3 taken together can represent cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, or cyclohexenyl; R4 is selected from the group consisting of H, methyl and ethyl; R5 is selected from the group consisting of H, methyl and ethyl; R6 is selected from the group consisting of H, C1-C9 straight or branched chain alkyl, alkenyl, alkyldienyl, acyclic or containing no more than one ring; with the proviso that in structure 1 when R4 is H or Me; and R5═H or methyl, R6 may be selected from the group described above or phenyl.

The invention discloses a medicament for treating composite water in a hot water boiler. The medicament comprises the following components by mass percent: 0.1-3% of inorganic phosphate, 0.1-2% of organic phosphoric acid and / or organic phosphate, 0.1-4% of component A, 0.1-3% of component B, 0.6-1.0% of organic amine deoxidizer, 0.1-2% of tannin and / or chitosan and the balance of water, wherein the mass percent of the components is 100%, the component A is one or more of an organic antisludging agent, an organic dispersant and an organic dispersible antisludging agent, and the component B is one or more of an organic carboxylic acid corrosion inhibitor, an organic carboxylate corrosion inhibitor and sodium methylene dinaphthalenesulfonate. The invention further discloses a preparation method and a use method of the medicament, the preparation process is clean, and the medicament is low in toxicity for body health and environment in the using process. The medicament is excellent in corrosion resistance and scale inhibition effects and simple and convenient to store and transport, and the corrosion and scale inhibition effects cannot be reduced after the medicament is stored and transported for a long term.

The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTBFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.

Improved polypropylene fibers exhibiting greatly reduced heat- and moisture-shrink problems and including certain compounds that quickly and effectively provide rigidity to the target polypropylene fiber after heat-setting are disclosed herein. In such a manner, the "rigidifying" compounds provide nucleation sites for polypropylene crystal growth. After drawing the nucleated composition into fiber form, the fiber is then exposed to sufficient heat to grow the crystalline network, thus holding the fiber in a desired position. The preferred "rigidifying" compounds include dibenzylidene sorbitol based compounds, as well as less preferred compounds, such as sodium beuzoate, certain sodium and lithium phosphate salts (such as sodium 2,2'-methylene-bis-(4,6-di-tert-butylphenyl)phosphate, otherwise known as NA-11).

The invention relates to a method for preparing activated carbon with humic acid as a raw material and an application of the activated carbon. The method comprises the steps of mixing industrial humic acid with an activating agent which is potassium hydroxide, sodium hydroxide, zinc chloride, potassium carbonate or phosphoric acid uniformly to react under inert atmosphere protection for 1-5 hours; then cooling the product, washing the product in an acid solution until the pH value is 6-7 and drying the product, thus obtaining the activated carbon. The method is convenient to operate, is relatively low in energy consumption and is suitable for large-scale industrial production. The humic acid porous activated carbon material obtained by the method has a rich porous structure and a relatively big specific surface area, is used for preparing water purifiers or electrode materials of supercapacitors, and has methylene blue dye adsorption value of 600mg / g. Besides, the humic acid porous activated carbon material is used as the electrode material of a supercapacitor to assemble a high-performance supercapacitor. The specific capacitance of the activated carbon single electrode is 351Fg<-1>. Various test results show that the activated carbon is microporous-mesoporous composite carbon and has specific surface area of about 3200m<2> / g, the pore size distribution of the activated carbon is 1-5nm, and the pore volume of the activated carbon is about 2cm<3> / g.

The invention is to provide liquid crystalline compounds having a negative and extremely large dielectric anisotropy value and a small optical anisotropy value at the same time; liquid crystal compositions comprising the compound; and liquid crystal display devices fabricated by using the liquid crystal composition; the liquid crystalline compounds have 2,3-dihalogenophenylene moiety and are expressed by formula (1)wherein Ra and Rb each independently represents a linear or branched alkyl having 1 to 10 carbon, any methylene in the alkyl may be replaced by -O-, -S-, -CH=CH-, or -C=C-, but -O- is not successive, and any hydrogen in the alkyl may be replaced by halogen; rings A1 to A4 each independently represents trans-1,4-cyclohexylene, cyclohexene-1,4-diyl, pyridine-1,4-diyl, pyrimidine-2,5-diyl, or 1,4-phenylene, wherein at least one hydrogen in these rings may be replaced by halogen, and any nonadjacent methylene in cyclohexane ring may be replaced by -O-; Y1 and Y2 each independently represents F or Cl; Z1, Z2 and Z3 each independently represents a single bond, -CH2CH2-, -(CH2)4-, -COO-, -OCO-, -CH2O-, -OCH2-, -CF2O-, or -OCF2-; and l, m and n each independently is 0, 1 or 2, and the sum of l+m+n is 3 and less.

The invention discloses application and a preparation method of biomass-based nitrogen-doped porous carbon. The method includes: taking cheap cellulose carbamate as a raw material and urea as a nitrogen source, well mixing with sodium hydroxide solution, drying to form sol, and performing high-temperature calcination to obtain the porous-structure biomass-based nitrogen-doped porous carbon high in specific surface area and pore volume. According to electron microscopy images, the prepared material is in a three-dimensional inner-crosslinked porous structure; according to XPS and elemental analysis, nitrogen is successfully doped into a carbon substrate, the nitrogen content is 7.7-15.5%, and the specific surface area is 700-3700m<2> / g; according to supercapacitor experiments, the biomass-based nitrogen-doped porous carbon is great in electrochemical performance; according to pollutant adsorption experimental data, the material is high in adsorption rate and adsorption capacity in adsorption of dye pollutant methylene blue, and the adsorption capacity reaches 1520mg / g. The method is simple in preparation, the raw materials are renewable, and low cost is realized. In addition, sodium carbonate which is a by-product is obtained by washing of calcined samples, so that cost can be effectively reduced, and economic benefits are increased.

The present invention provides Lig-and-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit. The invention provides inter alia, Ligand-Drug Conjugates, wherein the Ligand-Drug Conjugate is comprised of a Self-immolative Assembly Unit having a methylene carbamate unit for conjugation of a drug to a targeting ligand, methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates of the present invention are stable in circulation, yet capable of inflicting cell death once free drug is released from a Conjugate in the vicinity or within tumor cells.

The invention concerns a white, light-colored tire rubber composition, devoid of carbon black, comprising at least a diene elastomer, a reinforcing white or colored filler, and an anti-photo-oxidizing system, wherein said protective system comprises (A) a 2,2'-methylene-bis-[4-alkyl (C1-C10)-6-alkyl(C1-C12)phenol]; (B) a dialkylthiodipropionate, the alkyl radicals thereof, which may be identical or different, are (C1-C20), radicals; (C) a 2-(2-hydroxyphenyl) benzotriazole; and (D) a "HALS" amine derived from 2,2,6,6-tetramethylpiperidine.

The invention discloses a visible and reversible fluorescent probe which comprises a cyanine fluorescent group and a benzothiazole group, and the general formula of the probe is shown in the description. The preparation method of the reversible fluorescent probe comprises the following steps: (1) dropwise adding phosphorus oxychloride into salicylaldehyde and paraformaldehyde for reaction, so as to obtain a product 1; (2) enabling the product 1 and hexamethylene-tetramine to react, so as to obtain a product 2; (3) enabling the product 2 and 2-aminobenzenethiol to react at the room temperature, so as to obtain a product 3; (4) enabling the product 3 and a compound 4 to react, so as to obtain the visible and reversible fluorescent probe. According to the ratiometric fluorescent probe provided by the invention, obvious color variation can be found out under natural light or an ultra-violet lamp, and the qualitative detection of sulfur dioxide gas can be implemented under natural light or a hand-held ultra-violet lamp, so that the operation is simple, high convenience and quickness are achieved, and the effect is remarkable; the fluorescent probe can effectively prevent interference from other impurities in samples, and is excellent in selectivity; in addition, the cumbersome pre-processing process of samples is avoided, so that the detection efficiency is high.

There is provided a CRF receptor antagonist comprising a compound of the formula (I):A-W—Ar  (I)wherein, A is a group represented by the formula (A1) or (A2): (wherein, ring Aa is a 5- or 6-membered ring which may be further substituted; ring Ab is a 5- or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, —O—, —S—, etc.; Y1, Y2 and Q are independently optionally substituted carbon or nitrogen; is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, —O—, —S—, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.

The invention discloses a modified petroleum coke granule composite profile control water blocking agent and a multi-round bidirectional blocking control technology. The water blocking agent comprises agents A, B and C, the agent A comprises the ingredients: polyacrylamide solution with the concentration of 0.1-0.3% (by weight), sodium silicate, aluminum potassium sulfate, hydrochloric acid with the concentration of 30% ( by weight), and calcium chloride, the agent B comprises polyacrylamide solution with the concentration of 0.1-0.3% (by weight), modified petroleum coke granules of 20-800mum and surfactant, and the agent C comprises the ingredients: polyacrylamide solution with the concentration of 0.3-0.7% (by weight), N-N' methylene bisacrylamide, organic chromium crosslinking agent, and thiocarbamide; and the multi-round bidirectional blocking control technology is of a multi-round bidirectional blocking control measure developed according to geologic features, state and oil producing conditions of different regions of oil fields; and the water blocking agent is matched with the blocking control technology, so that the problems that the conventional profile control water blocking agent is low in strength, and bad in anti-erosion property and shearing resistance property can be solved, further digging of remaining petroleum is conducted, the water content ratio of an oil well can be reduced, the effect of displacement in flooding can be improved, and the production demand of the oil field can be met.

The invention discloses a preparation method and an application of a core-shell TiO2 / ZnIn2S4 composite photocatalyst. The preparation method comprises the following steps: performing ultrasonic dispersion on TiO2 in an ethanol solvent; adding zinc chloride and indium nitrate into the ethanol solvent, and stirring to dissolve; mixing the two systems, and adding thioacetamide; transferring the mixed system into a high pressure kettle to react; performing vacuum filtration, washing, drying and grinding on a product after the reaction is finished to obtain the core-shell TiO2 / ZnIn2S4 composite photocatalyst. According to the method, the core-shell TiO2 / ZnIn2S4 composite photocatalyst is prepared in one step by adopting a solvothermal synthesis method, the catalyst is wide in visible light response range and high in photocatalysis activity, is applicable to organic dye wastewater degradation, and can be used for degrading methylene blue-containing wastewater in the field of solar energy transformation and utilization and environment management.

A process for treating the methylene blue dye sewage features that the nano-class oxide of Mn is used as catalyst to catalyze the oxidizing of H2O2 to decompose the methylene blue dye.

The invention belongs to strong-fluorescence boron dipyrromethene dyes containing a carbazole structure in the technical field of organic chemical industry and fine chemical industry. Because a method for preparing the strong-fluorescence boron dipyrromethene dye containing the carbazole structure and derivatives thereof adopts boron dipyrromethene and carbazole aldehyde with substituent as raw materials, the molar ratio of the boron dipyrromethene to the carbazole aldehyde is 1:2-5, piperidine is a catalyst, a 4-angstrom molecular sieve is a dehydrating agent, and the molar ratio of the borondipyrromethene to the catalyst is 1:0.01-0.20; in an organic solvent, at the temperature of between 100 and 150 DEG C and under the protection of argon or nitrogen, the mixture reacts for 8 to 50 hours by stirring, the carbazole aldehyde and the active methylene of the boron dipyrromethene are dehydrated to generate the boron dipyrromethene derivatives; and after the carbazole structure with different substituents is introduced into the boron dipyrromethene, the optical property of the boron dipyrromethene compound is changed, the red shift of the absorption spectrum thereof is 80 nanometers, the red shift of the emission spectrum is 90 nanometers, higher fluorescence quantum yield is kept at 0.67, the laser efficiency reaches more than 30 percent, and the strong-fluorescence boron dipyrromethene derivatives containing the carbazole structure are obtained.

Compounds of the formula and quaternary ammonium ions thereof, wherein R1 and R2 are the same or different and are carbocyclic aryl or aromatic heterocyclic; A is methylene, carbonyl or sulfonyl; B is a single bond, C1-C4 alkylene or C2-C4, alkenylene; D is oxygen; E is C2 alkylene; G is C1-C4 alkylene or C2-C4 alkenylene; and L is -C(R4)(R5), wherein R4 and R5 together with the carbon atom to which they are attached represent a C5-C10 cycloalkyl or a C5-C10 heterocyclic. Especially preferred are compounds wherein L represents wherein J is a C1-C6 alkylene; Ar is a ring carbocyclic or aromatic heterocyclic and S*->O is a sulfoxide in which the sulfur atom is in the 5-configuration. The compounds have tachykinin receptor antagonist activity and exhibit an activity against both the NK1 and NK2 receptors.