The invention discloses a three-dimensional cultivation method for cortex phellodendri and rhizoma paridis interplanting. The three-dimensional cultivation method comprises the steps of cortex phellodendri planting, rhizoma paridis planting, field management, fertilization management, irrigation management and pest control. Interplanting is carried out in winter and spring, and a low-mountain yellow earth thick-layer three-dimensional land type is selected; cave-shaped soil preparation is adopted for cortex phellodendri, the height of each transplanted seedling is larger than or equal to 50 cm, and the ground diameter is larger than or equal to 1 cm; after ten to fourteen months of cortex phellodendri transplantation, rhizoma paridis transplantation is carried out, bedding is carried out between cortex phellodendri rows, tubers, with buds, of rhizoma paridis are transplanted to beds; a survey of the survival rate of the cortex phellodendri is carried out on the cortex phellodendri after two months of cortex phellodendri planting, a survey of the survival rate of the rhizoma paridis is carried out on the rhizoma paridis after six months of rhizoma paridis planting, and seedling supplement, weeding, soil loosening and pest control are carried out in time; when the overshadowing rate of the cortex phellodendri is lager than 65%, pruning or crossing or intermediate cutting is carried out to adjust the overshadowing rate; two times of top dressing are carried out in a growing season and in winter respectively, watering is carried out in time after planting is accomplished, watering is carried out in time in a dry season, and drainage needs to be smooth in a rainy season. According to the three-dimensional cultivation method for cortex phellodendri and rhizoma paridis interplanting, combined and targeted optimized cultivation of the cortex phellodendri and the rhizoma paridis is achieved, the yield of the cortex phellodendri and the yield of the rhizoma paridis are increased, quality of the cortex phellodendri and quality of the rhizoma paridis are improved, the economic benefit is remarkable, and the popularization and application value is high.