122results about How to "Large molecular weight" patented technology

Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.

The present invention relates to a powdery composition for nasal administration, which is characterized in that (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or alpha-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on / in the water-absorbing and water-insoluble base material than on / in the water-absorbing and gel-forming base material. The present invention provides the powdery composition for nasal administration excellent in absorption of the drug from the nasal cavity and having an extremely increased maximum blood concentration comparing a conventional composition for nasal administration even for a drug having a high solubility in water, a drug having a high lipophilicity or a peptide / proteinaceous drug having a large molecular weight.

The invention discloses a chiral tetra-amino aniline ligand, and a preparation method and application of an aluminum compound thereof. The structural formula of the ligand is represented as the formula (A), wherein R1 is alkyl in a C1-C4 straight chain branched chain structure. The aluminum coordination compound of the chiral tetra-amino aniline ligand can efficiently catalyze ring-opening polymerization reactions of lactide. The ligand and the aluminum compound of the ligand are simple to synthesize, high in product yield coefficient and stable in property, simultaneously catalyst activity is high, selectivity is good, the performance of an obtained polymer is good, and molecular weight and stereoselectivity of the polymer can be regulated by control of polymerization reaction conditions.

A method for producing a polylactic acid resin composition, including the following steps (1) and (2): step (1): subjecting an organic crystal nucleating agent to a wet pulverization in the presence of a carboxylic acid ester having a weight-average molecular weight of from 150 to 600 and a viscosity at 23° C. of from 1 to 500 mP·s and / or a phosphoric ester having a weight-average molecular weight of from 150 to 600 and a viscosity at 23° C. of from 1 to 500 mPa·s to give a finely pulverized organic crystal nucleating agent composition; and step (2): melt-kneading a raw material for a polylactic acid resin composition comprising the finely pulverized organic crystal nucleating agent composition obtained in the step (1) and a polylactic acid resin. The polylactic acid resin composition obtainable by the method of the present invention can be suitably used in various industrial applications, such as daily sundries, household electric appliance parts, packaging materials for household electric appliance parts, and automobile parts.

The present invention relates to a superabsorbent polymer showing a low degree of decrease in absorption capacity, and a preparation method thereof. Specifically, the present invention provides a superabsorbent polymer having an excellent rewetting prevention ability such that moisture hardly leaks out under pressure even after a certain time, and a preparation method thereof, by preparing an acrylic resin with a high molecular weight main chain that is evenly cross-linked for maintaining high gel strength by minimizing an amount of an initiator with respect to a monomer.

The present invention discloses a membrane for a fuel cell, comprising: a solid polymer electrolyte membrane composed of a crosslinked ion exchange resin, and a polymer having a weight-average molecular weight of 5,000 to 1,000,000 and having a charge group of polarity opposite to that of the ion exchange group of the ion exchange resin, which polymer is adhered onto at least one surface of the solid polymer electrolyte membrane in an amount of 0.0001 to 0.5 mg / cm3, preferably in a state that, when the membrane for fuel cell is immersed in a 50 mass % aqueous methanol solution of 30° C., there is substantially no difference in the adhesion amount of the polymer before and after the immersion; and a membrane-electrode assembly for a fuel cell, comprising the above-mentioned membrane, and a catalyst electrode layer bonded to the membrane, which catalyst electrode layer contains an ion exchange resin having the same polarity as the crosslinked ion exchange resin composing the solid polymer electrolyte membrane, and a catalyst substance.

The invention discloses a conditioning agent of high-nutrient saline soil and a preparation method and application thereof. The conditioning agent is prepared from charcoal, non-ionic polyacrylamide, anionic polyacrylamide, cationic polyacrylamide, lignite and kieselguhr according to the mass ratio of (5 to 10):(2 to 4):(2 to 4):(1 to 3):(3 to 5):1. The conditioning agent provided by the invention solves a series of problems of poor soil physical property, high ion content, low soil quality and the like caused by the saline phenomenon on the soil; the soil volume weight is reduced; the soil porosity degree is increased; the exchange of water, gas, heat and the like in the soil can be facilitated; the soil fertility is improved; meanwhile, the salt ion content and the whole salt content are reduced; the harm to the soil and the crops is reduced, so that the crop yield is increased.

A conductive polyaniline composition of a substituted or unsubstituted polyaniline complex and a compound with a phenolic hydroxyl group dissolved in an organic solvent substantially immiscible with water that is capable of producing a molded article possessing high conductivity.

The present invention relates to a liquid formulation of a combination of long-acting insulin and insulinotropic peptide, comprising insulin which is a physiologically active peptide, insulinotropic peptide, and albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent; and a method for preparing the liquid formulation. The liquid formulation of the present invention does not contain a human serum albumin and potentially toxic factors to the body, and thus it has excellent storage stability for insulin conjugate and insulinotropic peptide conjugate at high concentration, without a risk of viral contamination.

A process for producing 2-acrylamide-2-methyl propane sulfonic acid (ATBS) which comprises reacting acrylonitrile, fuming sulfuric acid, and isobutylene. During the reaction, the concentration of 2-methyl-2-propenyl-1-sulfonic acid (IBSA) and / or that of 2-methylidene-1,3-propylenedisulfonic acid (IBDSA) in the reaction system are determined. When the IBSA concentration exceeds 12,000 mass ppm and / or the IBDSA concentration exceeds 6,000 mass ppm, then the concentration of sulfur trioxide in the reaction system is reduced. Thus, ATBS having an IBSA content of 100 mass ppm or lower and an IBDSA content of 100 mass ppm or lower is produced.

A photothermographic material is disclosed, comprising on one side of a support a light-sensitive layer comprising a light sensitive silver halide, light-insensitive silver salts of aliphatic carboyxlic acids, a reducing agent and a binder resin and a light-insensitive layer and on the other side of the support a light-insensitive layer, wherein the light-insensitive layer on the light-sensitive layer side and the light-insensitive layer on the other side of the support comprises a silicon-containing polymer lubricant and a fluorine-containing compound represented by formula (SF):[Rf-(L1)m1-]p-(L2)n1-(A)q  Formula (SF).