1930 results about "Hydroxylation" patented technology

Non-hydroxyalkylated cyclodextrins are disclosed wherein at least one primary alcohol function (CH2OH) is substituted, the -OH portion being replaced by a substituent with formula -O-CO-R or -NR1R2, where:R, R1 and R2 independently represent a linear or cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated alkyl group containing 1 to 30 carbon atoms, preferably 1 to 22 carbon atoms, more preferably a fatty chain containing 2 to 22 carbon atoms. These cyclodextrins are used as vectors for at least one active ingredient, in particular to encourage tissue penetration, in a cosmetic application, or for the production of pharmaceutical compositions, in particular dermopharmaceuticals.

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.

The invention relates to an oil-in-water nanoemulsion having an oily phase dispersed in an aqueous phase, the oil globules of which have a number-average size of less than 100 nm, containing: (i) at least one amphiphilic lipid comprising at least one nonionic amphiphilic lipid, and optionally at least one ionic amphiphilic lipid, the oily phase and the amphiphilic lipid being present at a content such that the oily phase/amphiphilic lipid weight ratio ranges from 3 to 10, and (ii) at least one hydroxylated urea derivative. Application in cosmetics, dermatology, and ophthalmology.

The invention provides a method for preparing a small-crystallite titanium-silicon molecular sieve in a cheap system by changing the adding mode of seed crystals and by a hydrothermal process. The titanium-silicon molecular sieve is prepared by using silicon sol as a silicon source, titanium tetrachloride or tetrabutyl titanate as a titanium source, tetrapropylammonium bromide ( TPABr) as a template agent, organic amine as an alkali source and unseparated nanoscale TS-1 mother liquor as seed crystals directly and by the hydrothermal process. The grain size of the titanium-silicon molecular sieve is less than 1 micrometer, and the titanium-silicon molecular sieve has high activity for selective oxidization reactions using hydrogen peroxide as an oxidant, such as epoxidation of olefins, hydroxylation of phenol, ammoxidation of cyclohexanone and the like. The method simplifies the synthesis process of small crystallite TS-1 in the cheap system and reduces synthesis time and cost.

A process for treating organic compounds includes providing a composition which includes a substantially mesoporous structure of silica containing at least 97% by volume of pores having a pore size ranging from about 15 Å to about 30 Å and having a micropore volume of at least about 0.01 cc/g, wherein the mesoporous structure has incorporated therewith at least about 0.02% by weight of at least one catalytically and/or chemically active heteroatom selected from the group consisting of Al, Ti, V, Cr, Zn, Fe, Sn, Mo, Ga, Ni, Co, In, Zr, Mn, Cu, Mg, Pd, Pt and W, and the catalyst has an X-ray diffraction pattern with one peak at 0.3° to about 3.5° at 2θ. The catalyst is contacted with an organic feed under reaction conditions wherein the treating process is selected from alkylation, acylation, oligomerization, selective oxidation, hydrotreating, isomerization, demetalation, catalytic dewaxing, hydroxylation, hydrogenation, ammoximation, isomerization, dehydrogenation, cracking and adsorption.

The invention discloses a Ti-Si molecular sieve/diatomite composite catalyst and a preparation method thereof, which is characterized in that: the catalyst is formed by compounding Ti-Si molecular sieve (such as TS-1 and TS-2) and diatomite with particular chemical property which is treated in a particular way, and is modified chemically by transition metal oxide after molding; the preparation method comprises the following steps: (1) after being treated with acid solution and alkaline solution, the diatomite needs heat treatment in high temperature to obtain particular chemical property; (2) the molding Ti-Si molecular sieve/diatomite composite catalyst is modified chemically by transition metal oxide (such as lanthanum and nickel). The composite catalyst can be used as the catalyst of selective oxidation reaction of the organic compound (such as the catalytic hydroxylation reaction of phenol) on fixed bed liquidoid, which uses hydrogen peroxide as the oxidant. The Ti-Si molecular sieve/diatomite composite catalyst has the advantages of high catalytic activity, high stability, long service life and easy separation, recovery and regeneration of the catalyst. When using the catalyst in the hydroxylation reaction of phenol of fixed bed liquidoid, under the reaction conditions of 84 DEG C, atmospheric pressure and 8.46h<-1> space velocity, the conversion rate of phenol is greater than 33%, the selectivity of diphenol reaches 99.9%, and the effective use rate of hydrogen peroxide is greater than 85%.

The invention discloses a hydroxylated tung oil and an ester group-aminated preparation method, belonging to the technical field of organic chemosynthesis. In the method, under a certain condition, ester groups in the tung oil and diethanol amine are subjected to aminolysis reaction on the premise of reserving conjugated double bonds, thus the tung oil is hydroxylated to mainly produce a compound containing terminated hydroxyl and three conjugated double bonds. The structural formula of the compound is shown in the specification. The aminolysis reaction product plays an important role in developing and producing processes of leading the tung oil into waterborne polyurethane, not only can combine the advantages of the tung oil and the polyurethane, but also can improve the utilization ratio of tung oil resources as special local products in China and decrease the dependence on petroleum products; and simultaneously, the method has the advantages of simplicity, practicability, high conversion rate and convenience in industrialized production.

Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3.

A process for manufacturing an α-dihydroxy derivative from an aryl allyl ether wherein such α-dihydroxy derivative can be used to prepare an α-halohydrin intermediate and an epoxy resin prepared therefrom including epoxidizing an α-halohydrin intermediate produced from a halide substitution of an α-dihydroxy derivative which has been obtained by a dihydroxylation reaction of an aryl allyl ether in the presence of an oxidant or in the presence of an oxidant and a catalyst.

The invention provides a tin-titanium-silicon molecular sieve and a preparation method and application thereof. The tin-titanium-silicon molecular sieve contains elemental silicon, elemental titanium, elemental tin and elemental oxygen, and the interiors of at least a part of crystal grains of the tin-titanium-silicon molecular sieve have hole structures. The invention provides a method for hydroxylation of phenol. The method comprises a step of contacting phenol and hydrogen peroxide with a catalyst under the conditions of phenol hydroxylation, wherein the catalyst contains the tin-titanium-silicon molecular sieve provided by the invention. The tin-titanium-silicon molecular sieve provided by the invention has good catalytic oxidation; if applied to phenol hydroxylation, the tin-titanium-silicon molecular sieve provided has higher catalytic oxidation activity and particularly high selectivity on a para-position product hydroquinone compared with titanium-silicon molecular sieve not containing tin or a tin-loaded titanium-silicon molecular sieve.

The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2-methyl-2-phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric. The invention also provides processes for making these analogs. The invention also provides the two individual enantiomers of DL-2-methyl-2-phthalimidinoglutaric acid, (R)-(+)-2-methyl-2-phthalimidinoglutaric acid and (S)-(−)-2-methyl-2-phthalimidinoglutaric acid, and processes for separating these individual enantiomers from the racemate. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering one or more of these compounds.

The invention relates to a method for and purpose of synthesizing the polyols macromonomers based on plant oil polyols macromonomer, which comprise the steps that: A) the hydroxylation vegetable oil is obtained by hydroxylation of vegetable oil; B) By making the hydroxylation vegetable oil in A) react with the isocyanate, the modified plant oil macromonomer is obtained. For the detailed steps, see the specification. The invention has the advantages that: the plant oil is the renewable resource with good biodegradability and avirulence, and the oil is a clean and abundant raw material, also environment-friendly 'bio-surfactant' polyol, and can increase 'green content' of soft polyurethane foam material. Our country is a large one engaged in producing the plant oil, and has a yield runningthe third in the world. So, forcefully researching and developing plant oil-based products to substitute the petroleum derivatives are of great importance. The modified plant oil macromonomer in StepB) can be used for preparing high solid polymer polyol that is suitable for soft polyurethane foam material and used for furniture, carpet and bedding industries.