45results about How to "Enhanced solubilization" patented technology

The invention provides a method for reducing aggregation and inhibiting flocculation of a macromolecule, such as a protein, under physiological conditions, by the addition of 5% to 20% polyvinylpyrrolidone (PVP) with a molecular weight range of 2000 to 54,000 daltons. The invention further provides a method to minimize inflammation at the injection site during subcutaneous administration of a macromolecule. In further aspects, the invention provides pharmaceutical formulations for subcutaneous administration of a macromolecule, and methods of treating a CD20 positive cancer or an autoimmune disease, comprising administering a humanized anti-CD20 antibody in a pharmaceutical formulation of the invention. The invention further provides an in vitro dialysis method to evaluate the ability of an excipient to reduce aggregation of an antibody or other macromolecule under physiological conditions.

The invention is a cleaning agent for cleaning a ceramic filter plate, which comprises 0.1-5% nitric acid, 0.1-5% hydrochloric acid, 0.2-3% hydrofluoric acid, and 0.1-5% oxalic acid of aqueous solution. Under the combined action of nitric acid, hydrochloric acid, and hydrofluoric acid, it can achieve mixed dirt such as carbonate, silicate, sulfate, phosphate, sulfide, hydroxide, and slime under normal temperature and pressure conditions. The cleaning effect is good, and the application range is wide, which can improve the service life of the filter plate and expand the application range of the ceramic filter.

The invention relates to a method for removing micro organic pollutants from tap water through Pluronic block copolymers. The Pluronic block copolymers are utilized to form large-sized micelles capable of being effectively separated by an ultrafiltration membrane, and the micelles are taken as carriers which are used for dissolving the micro organic pollutants in the tap water and then can be removed by ultrafiltration; meanwhile, the reversible conversion between monomer molecules and the micelles is controlled through simple temperature adjustment by a sensitive temperature effect of compound micellization to achieve regeneration recycling of the Pluronic block copolymers.

Microbial compositions for application to plants, plant parts and plant seeds are provided for improvement of plant yield and / or other beneficial plant traits. Methods of making and applying microbial compositions or formulations to plants, plant parts or plant seeds or to growth media are further provided to increase or improve plant yield and / or other beneficial plant traits.

The invention provides a method for improving the antimicrobial activity of a stainless steel product. The method comprises the following steps that a, stainless steel is subjected to ultrasonic cleaning; b, the stainless steel obtained in the step a is soaked in a polyvinylpyrrolidone solution; c, the stainless steel in the step b is fast soaked with an AgNO3 solution and is stirred; d , the stainless steel prepared in the step c is dried; and e, the above steps are repeated 6-15 times, and the antimicrobial stainless steel product can be obtained. The method is simple in process and high incontrollability, and the treated stainless steel has a good antibacterial property. The surface of the stainless steel is pretreated in advance, so that the surface of the stainless steel is higher inantibacterial capacity, and the stainless steel can be widely applied to various fields that the stainless steel is adopted as a material and the antibacterial property is needed.

An organic acid composition for use in oil industry activities, said composition comprising: methane sulphonic acid; a metal iodide or iodate; and an alcohol or derivative thereof. The uses include: injection / disposal in wells; squeezes and soaks or bullheads; acid fracturing; acid washes or matrix stimulations; fracturing spearheads (breakdowns); pipeline scale treatments; cement breakdowns or perforation cleaning; pH control; and de-scaling applications.

The invention discloses a hydrating mask and a preparation method thereof and belongs to the technical field of cosmetics. According to the hydrating mask disclosed in the invention, sucrose stearateand sodium deoxycholate are compounded to form an emulsion system, electric charge of the compound micelle is determined by an anionic surfactant sodium deoxycholate, and the charge is negative. By adding the NaCl solution, the concentration of the counter-ion Na<+> in the solution is increased, the solubility of the active material in the whole hydrating mask is improved, and the active materialcan be dissolved and absorbed by skin as much as possible. Meanwhile, antioxidant tea polyphenol and DNA repairing myricetin can be solubilized by utilizing the emulsion state, the carrier is improved, and repair of facial skin and cell activation can be improved. According to the hydrating mask disclosed in the invention, the problems that the conventional hydrating mask is poor in hydrating effect and substances irritating the skin are added can be solved.

A decontaminant composition comprising a peroxide; an organic co-solvent; an amine, which in reaction with the peroxide is a source of a perhydrolysis species; a phase transfer catalyst comprising at least one quaternary ammonium compound; a metal oxide catalyst; a chemical base; and at least one pH buffering compound.

The present invention discloses novel formulations, reconstitutable solid compositions, pharmaceutical compositions, and aqueous injectable formulations of specific amidine substituted beta-lactam compounds on the basis of modified cyclodextrins and organic and / or inorganic acids, their preparation and use as antimicrobial pharmaceutical compositions that are parenterally or orally administrable.

The present invention discloses a new efficient process for the preparation of the KDR-targeting peptide-phospholipid conjugate of formula (I), which can be useful in therapeutic and diagnostic compositions and particularly in the preparation of ultrasound contrast agents.

The invention provides a powerful cleaning agent for oily dirt and a preparation method thereof. Oily dirt cleaning agent, in parts by weight, consists of the following components: 35-50 parts of oil, 21.5-53.5 parts of water, 1-5 parts of cationic surfactant, and 1-5 parts of anionic surfactant , 1-5 parts of nonionic surfactant, 8-12 parts of co-surfactant n-butanol, 0-0.5 part of sodium chloride, 0.5-1 part of builder sodium tripolyphosphate. The invention uses an anionic / cationic surfactant with strong solubilizing ability and a degradable nonionic surfactant compound microemulsion as the mother liquor, and supplemented with several performance additives to achieve both rust prevention and decontamination. , The advantages of repeated use of lotion, green and environmental protection, unlimited oil content, has great economic value. Simultaneously, the present invention also realizes the diversification of cleaning objects, and materials such as metal, glass, plastic, cloth, leather, pottery, and rubber can all be used, and has good application prospects.

The invention discloses a preparation process of beta-glucan. The process comprises the following steps of firstly screening strains: preparing a plurality of strains, qualitatively detecting the strains by using a Congo red agar staining method, detecting the beta-1, 3-glucanase activity of each strain, and screening out the strain with the relatively high enzyme activity as a strain to be cultured; and secondly culturing the strain: performing slant seed culture for 7-8 days first, and then inoculating the strain to a plate culture medium for culture, wherein the plate culture medium comprises the following components: 28-30 g / L of glucose, 1-2 g / L of potassium dihydrogen phosphate, 6-10 g / L of yeast extract, 18-20 g / L of agar, 1-2 g / L of magnesium sulfate and 2-3 g / L of ammonium chloride. The preparation process of the beta-glucan is reasonable in design and easy to operate; the beta-glucan is prepared through fermentation, separation and purification of schizophyllum commune and optimization and improvement of various parameters and steps; the beta-glucan is good in water solubility, high in biological activity and relatively high in crude sugar yield, retention rate and purity; and the preparation process can be applied to large-scale production, is low in cost and has relatively high practicability.

The invention discloses an oil contaminated soil remediation method. The method comprises the following steps: (1) preparing an inorganic culture solution; (2) adding a composite carbon source into the inorganic culture solution, performing high temperature sterilization, inoculating pseudomonas aeruginosa, and performing constant temperature culture for 96-108 h; (3) diluting a fermentation brothwith clean water and adjusting pH with NaOH to form a cleaning solution; (4) adding oil contaminated soil into the cleaning solution, and performing ultrasonic cleaning for 3-4 min at an ultrasonic frequency of 10-20 kHz; and (5) performing filtering and centrifugal separation on the mixture. The method adopts a method of "treating pollution with pollution", a pollutant is used as an inducing factor to be added into a specific culture medium, and then a produced fermentation broth acts on the pollutant. The fermentation broth production process has low requirements, obtaining of the production raw materials are convenient, no foreign microorganisms are introduced, ultrasonic equipment is simple and easy to operate, the cost for treating the oil-contaminated soil is low, and the method hasno damage to a soil structure, no secondary pollution, and high efficiency, and has significant remediation effects.

The invention provides a sea cauliflower macrobenthos economic wetland system for treating farmland runoff, comprising: a pesticide removal tank, which is connected to the water outlet of the water inlet tank, and filled in the tank body of the pesticide removal tank There are straws; the wetland unit is connected to the water outlet of the pesticide removal tank, and the bottom of the wetland unit is sequentially provided with a clay waterproof layer, a substrate layer and a flooded layer, and seaweed is planted on the substrate layer. Cauliflower, snails and the like are also placed in the wetland unit. The invention removes pesticides and provides carbon sources for the wetland unit through the pesticide removal pond equipped with straw, so that the microorganisms, sea cauliflower and snails in the wetland unit can form a good ecological cycle system, so that the wetland system can run stably for a long time. And the sea cauliflower and snails in the wetland unit have high economic value, which can further improve the economic performance of the wetland.