Preparation method of hedera helix extract

A technology of ivy extract and hedera glycosides is applied in the field of preparation of ivy extract, and can solve the problems of low purity of the extract and the like

Active Publication Date: 2022-07-29
CHANGSHA LANGLIN BIOLOGY PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

That is, the purity of the extract prepared by the above method is low

Method used

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  • Preparation method of hedera helix extract
  • Preparation method of hedera helix extract
  • Preparation method of hedera helix extract

Examples

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Effect test

Embodiment 1

[0123] The present embodiment is a preparation method of ivy extract, which consists of the following steps:

[0124] S1. Ultrasound-assisted extraction:

[0125] The dry raw materials of ivy leaves were crushed to 40 meshes, 15 times the mass of the extractant solution was added, and ultrasonic-assisted continuous countercurrent extraction was carried out at 45 ° C for 30 min; solid-liquid separation; The sum of the content with α-hederin is 53.97%).

[0126] The mass fraction of the aid in the aid solution is 0.3‰.

[0127] The extracting agent consists of Tween 20 (CAS number: 9005-64-5) and hydroxypropyl chitosan (Shanghai Shifeng Biotechnology Co., Ltd., degree of substitution ≥ 80%; CAS number: 104673-29-2) composition, the mass ratio of Tween 20 to hydroxypropyl chitosan was 2.5:1.

[0128] The pH of the extractant solution was 8.5 (pH at 25°C; adjusted by adding sodium hydroxide).

[0129] The ultrasound-assisted conditions are as follows: low-frequency intermitten...

Embodiment 2

[0141] The present embodiment is a preparation method of ivy extract, which consists of the following steps:

[0142] S1. Ultrasound-assisted extraction:

[0143] The dry raw materials of ivy leaves were crushed to 60 meshes, 20 times the mass of the extractant solution was added, and the ultrasonic-assisted continuous countercurrent extraction was carried out at 60 ° C for 45 min; solid-liquid separation; The sum of the content with α-hederin is 52.79%).

[0144] The mass fraction of the aid in the aid solution is 0.6‰.

[0145] The extracting agent consists of Tween 20 (CAS number: 9005-64-5) and hydroxypropyl chitosan (Shanghai Shifeng Biotechnology Co., Ltd., degree of substitution ≥ 80%; CAS number: 104673-29-2) composition, the mass ratio of Tween 20 to hydroxypropyl chitosan is 6:1.

[0146] The pH of the extractant solution was 7.5 (pH at 25°C; adjusted by addition of sodium bicarbonate).

[0147] The conditions of ultrasound assistance are as follows: low-frequenc...

Embodiment 3

[0159] The present embodiment is a preparation method of ivy extract, which consists of the following steps:

[0160] S1. Ultrasound-assisted extraction:

[0161] The dry raw materials of ivy leaves were crushed to 60 mesh, and 18 times the mass of the extractant solution was added, and ultrasonic-assisted continuous countercurrent extraction was carried out at 55 ° C for 40 min; solid-liquid separation; The sum of the content of α-hederin and 53.07%).

[0162] The mass fraction of the aid in the aid solution is 0.4‰.

[0163] The extracting agent consists of Tween 20 (CAS number: 9005-64-5) and hydroxypropyl chitosan (Shanghai Shifeng Biotechnology Co., Ltd., degree of substitution ≥ 80%; CAS number: 104673-29-2) composition, the mass ratio of Tween 20 to hydroxypropyl chitosan is 4:1.

[0164] The pH of the extractant solution was 8.0 (pH at 25°C; adjusted by adding potassium hydroxide).

[0165] The ultrasound-assisted conditions are as follows: low-frequency intermitte...

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Abstract

The invention relates to a preparation method of a hedera helix extract, and belongs to the technical field of extraction and processing of plants. The preparation method comprises the following steps: S1, mixing a hedera helix raw material with an extraction aid solution, and performing ultrasonic extraction to obtain an extracting solution; s2, concentrating the extracting solution, mixing the concentrated extracting solution with ethanol, and collecting a concentrated solution; s3, enabling the concentrated solution to pass through an aluminum oxide chromatographic column, and eluting with water, an ethanol water solution and an acidic ethanol water solution in sequence; collecting an eluent of the ethanol water solution to prepare a hederacoside C eluent; collecting an eluent of the acidic ethanol water solution to prepare an alpha-hederan eluent; s4, crystallizing the hederacoside C eluent, so as to obtain a hederacoside C extract; and crystallizing the alpha-hederan eluent to obtain the alpha-hederan extract, the extraction aid solution is prepared from the following raw materials: a surfactant and a flocculating agent. According to the method, the high-purity hederacoside extract is prepared.

Description

technical field [0001] The invention belongs to the technical field of extraction and processing of plants, and in particular relates to a preparation method of an ivy extract. Background technique [0002] Ivy (Latin name: Hedera nepalensis var.sinensis (Tobl.)) is the dry stems and leaves of Araliaceae ivy, also known as earth drum vine, drill sky wind, triangle wind, from the "Compendium of Materia Medica", has the effect of dispelling wind Dampness, promoting blood circulation and reducing swelling, calming the liver and detoxifying. The main components of ivy are triterpenoid saponins, carotene, tannins, sugars, etc. Among them, the stems contain hederasides, tannins (about 12.01% by mass), resins, etc., and the leaves contain hederacosides, inositol, Carotene, carbohydrates, and other tannins are about 29.4%. Saponins (such as triterpenoid saponins) are the most active ingredients found in ivy plants, and have various pharmacological activities such as anti-inflammat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00
CPCC07J63/008Y02A50/30
Inventor 贺玉婷
Owner CHANGSHA LANGLIN BIOLOGY PROD
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