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Application of chlorogenic acid to preparing medicine for treating allergic rhinitis

A technology for allergic rhinitis and chlorogenic acid, applied in the field of chlorogenic acid, can solve problems such as difficult treatment, difficult cure, and easy recurrence

Inactive Publication Date: 2015-12-16
洪铁 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Symptoms of allergic rhinitis are similar to those of colds. Therefore, many patients often treat allergic rhinitis as a cold at the early stage of the disease, take anti-cold medicines by themselves or seek medical treatment in other departments, but cannot receive timely and correct diagnosis and treatment.
Allergic rhinitis is an intractable disease, not only difficult to treat, but also very easy to relapse, difficult to cure completely

Method used

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  • Application of chlorogenic acid to preparing medicine for treating allergic rhinitis
  • Application of chlorogenic acid to preparing medicine for treating allergic rhinitis
  • Application of chlorogenic acid to preparing medicine for treating allergic rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1. Chlorogenic acid injection

[0012] prescription:

[0013] Chlorogenic acid 1g

[0014] Sodium bisulfite 0.2g

[0015] Add water for injection to 100ml

[0016] Take chlorogenic acid and add 80% water for injection, stir and dissolve, slowly add water for injection containing sodium bisulfite under stirring to obtain a clear solution, add water for injection to the full amount. Packed into 100 glass ampoules, sterilized after filling. Each injection contains 10mg of chlorogenic acid.

Embodiment 2

[0017] Example 2. Chlorogenic acid powder for injection

[0018] prescription:

[0019] Chlorogenic acid 1g

[0020] Mannitol 1g

[0021] Add chlorogenic acid to 30ml of water for injection and stir to dissolve, then mix with 20ml of mannitol aqueous solution, filter and sterilize, divide into 100 vials, and freeze-dry. Each bottle contains 10mg of chlorogenic acid. Before use, add 1ml of water for injection and shake to dissolve quickly.

Embodiment 3

[0022] Embodiment 3. Chlorogenic acid tablets

[0023] prescription:

[0024] Chlorogenic acid 10g

[0025] Lactose 120g

[0026] Sodium carboxymethyl starch 8g

[0027] Polyvinylpyrrolidone 2g

[0028] Magnesium stearate 0.5g

[0029] Take chlorogenic acid and grind it through a 100-mesh sieve, then mix it with lactose and carboxymethyl starch sodium evenly, take 10% polyvinylpyrrolidone aqueous solution to make a soft material, pass it through a 20-mesh sieve to prepare wet granules, dry at 60°C, and dry the granules with 20 Sieve the granules, mix with magnesium stearate evenly, punch tablets with 7mm dimples, and the average tablet weight is 140mg. Each tablet contains 100mg of chlorogenic acid.

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PUM

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Abstract

The invention discloses application of chlorogenic acid to preparing medicine for treating allergic rhinitis. The chlorogenic acid can be used for preparing compositions in diversified forms. The compositions include oral, injection and lung inhalation preparations and particularly include injection, oral liquid, tablets, capsules, granules, aerosol, powder aerosol and spray.

Description

technical field [0001] The invention relates to the application of chlorogenic acid, in particular to the application and composition of chlorogenic acid in the preparation of medicine for treating allergic rhinitis. Background technique [0002] Allergic rhinitis (al1ergiCrhinitis), also known as allergic rhinitis, is the release of mediators (mainly histamine) mediated by IgE after a specific individual contacts an allergen, and has a variety of immune active cells and cells Chronic inflammatory response diseases of the nasal mucosa with factors such as factors involved. The typical symptoms of allergic rhinitis are mainly continuous attacks of paroxysmal sneezing, a large amount of watery clear nasal discharge, followed by nasal congestion and nasal itching. Some patients have hyposmia, but it is temporary. sex. Chronic simple rhinitis is based on the disorder of the nerve regulation function of the nasal blood vessels, the parasympathetic nerve is dominant, and the symp...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P11/02A61P37/08
Inventor 洪铁李洪辛
Owner 洪铁
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