The invention relates to a novel
inhalation preparation, in particular to a preparation suitable for
inhalation drug administration of children
ranging from 0 to 12 years. After
medicine difficult to be dissolved in water and auxiliary materials are mixed, a
wet grinding method is adopted for smashing, mixed suspension liquid containing particles with the particle size appropriate is obtained, the particle size is 0.1-7 microns, and preferentially, the particle size is 0.1-5 microns; and further, the preferential particle size is 0.1-3 microns.
Solid powder is obtained through a freeze-
drying method. Sealing is performed for obtaining the novel
inhalation; and before use, the novel inhalation preparation is mixed with liquid suitable for atomization, re-dispersion is performed, and the mixed suspension liquid capable of being used for atomizing inhalation of children is obtained. The preparation is stored and transported in the form of the
solid powder, the problem that when a mixed suspension liquid form is adopted, the
physical stability and the
chemical stability are poor is avoided, the
medicine particle size hardly changes,
impurity increase is little, and the content hardly changes. Compared with
inhalation powder aerosol, the novel inhalation preparation is especially suitable for atomizing
medicine administration of children, medicine smaller in particle size can be adopted, and even though under the situations that
breathing of an infant is slight and the effective portion
deposition rate is low, an ideal medicine effect can also be achieved.