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Chloroquine phosphate inhalation aerosol and preparation method thereof

A technology of chloroquine phosphate and aerosol, which is applied in the field of medicine to achieve the effects of easy portability, improved stability, and simple use

Inactive Publication Date: 2020-05-08
JIANGSU ALICORN PHARMATECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For 2019-nCoV, there is currently no specific antiviral drug in the world. It is mainly for symptomatic treatment of patients. There is no effective antiviral drug. In view of the current epidemic situation, it is necessary to quickly find suitable antiviral drugs and use them rationally. Timing is of great significance for treating infected people, controlling the spread of the epidemic, and reducing the fatality rate

Method used

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  • Chloroquine phosphate inhalation aerosol and preparation method thereof
  • Chloroquine phosphate inhalation aerosol and preparation method thereof
  • Chloroquine phosphate inhalation aerosol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 Chloroquine Phosphate Micronization

[0032] Chloroquine phosphate is micronized in a jet mill, and the crushing pressure is 0.4 to 1.2Mpa, and the particle size of the obtained product is D 50 ≤3μm, D 90 ≤5μm.

Embodiment 2

[0034] Chloroquine Phosphate 5.0g

[0035] Water for injection 100.0g

[0036] Add HFA-134a to 1000.0g

[0037] Preparation method: Stir and dissolve in water for injection, slowly add the micronized active drug obtained in Example 1 and stir until a clear and transparent solution is formed, then add it into a pressure-resistant container; insert the valve into the pressure-resistant container, seal the valve, and pour the propellant Put it on and get it.

Embodiment 3

[0039]

[0040]

[0041] Preparation method: add the flavoring agent into the water for injection and stir to dissolve, slowly add the micronized active drug obtained in Example 1 and stir until a clear and transparent solution is formed, then add it into a pressure-resistant container; insert and seal the valve in the pressure-resistant container , Propellant filling, that is.

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Abstract

The invention belongs to the technical field of medicine, and discloses a chloroquine phosphate inhalation aerosol and a preparation method thereof. The chloroquine phosphate inhalation aerosol is composed of active ingredient chloroquine phosphate and a certain proportion of a propellant, a flavoring agent, a pH regulator and water for injection. The aerosol inhaler is administered through mouthsand directly acts on lungs to realize targeted drug delivery. The inhalation preparation provided by the invention can target lesion, has an accurate dosage and a fast effect, can quickly improve theinfection conditions of the lungs, facilitates improving the adaptability of infected people, and avoids absorption through gastrointestinal tracts to reduce gastrointestinal side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to a chloroquine phosphate inhalation aerosol and a preparation method thereof. Background technique [0002] For 2019-nCoV, there is currently no specific antiviral drug in the world. It is mainly for symptomatic treatment of patients. There is no effective antiviral drug. In view of the current epidemic situation, it is necessary to quickly find suitable antiviral drugs and use them rationally. Timing is of great significance for treating infected people, controlling the spread of the epidemic, and reducing the fatality rate. [0003] The receptor binding pathway of 2019-nCoV virus and SARS coronavirus is similar, through the molecular mechanism of S-protein binding and interaction with human ACE2 receptor, and ACE2 exists in alveolar and small intestinal epithelial cells, and in arteriovenous epithelial cells of all organs It is expressed on the surface of arter...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K47/06A61K31/4706A61P31/14
CPCA61K9/0078A61K9/124A61K31/4706A61K47/06A61P31/14
Inventor 宋敏舒欣高超刘玉先
Owner JIANGSU ALICORN PHARMATECH CO LTD
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