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Application of earthworm injection in atomization and rectal administration and preparation method thereof

A technology of rectal administration and injection, which is applied in the field of pharmaceutical preparations and can solve problems such as reducing patient compliance, broken needles, and infections

Inactive Publication Date: 2019-02-01
广东新峰药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology solves problems with administered drugs that have negative side-effects on breathing or gastrointestive systems such as nasopharyngeaemia (Nasthmatism), which can cause dyspnea when taken into account for symptoms like difficulty swallowing due to their low acidic nature). These solutions also work well at delivering them directly onto tissue surfaces without causing damage during treatment procedures.

Problems solved by technology

The technical problem addressed in this patented text is that current methods like injectors are associated with potential safety concerns due to their use during treatments or when patients have difficulty swallowing them themselves.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Add Sargassum Injection, Maodongqing Injection and an osmotic pressure regulator with a mass fraction of 0.2% to Dilong Injection, and adjust the pH value to 6.3 with a pH regulator, and use an ultrasonic or compression atomization mechanism to obtain the solution Inhalation of nebulized preparations, direct inhalation of the respiratory system in the form of nebulization or coverage of the respiratory system through local spraying;

[0015] Wherein, the osmotic pressure regulator is one of sodium chloride, boric acid, glucose and borax.

[0016] Wherein, the pH regulator is hydrochloric acid and sodium hydroxide.

Embodiment 2

[0018] Add sarcorrhizae injection, Maodongqing injection and a rectal absorption accelerator with a mass fraction of 0.25% to Dilong injection, and adjust the pH value to 6.5 with a pH regulator, and make the resulting solution into a rectal administration preparation or The resulting solution is placed in a dropper to make a rectal drip preparation, which enters the blood circulation through the rectal vein.

[0019] Wherein, the pH regulator is hydrochloric acid and sodium hydroxide.

[0020] Wherein, the rectal absorption accelerator is one of salicylate, 5-methoxysalicylic acid, surfactant, enamine and its derivatives, and fatty acid.

Embodiment 3

[0022] Add Sargassum Injection, Maodongqing Injection and an osmotic pressure regulator with a mass fraction of 0.3% to Dilong Injection, and adjust the pH value to 6.8 with a pH regulator, and put the resulting solution into a dropper to make rectal The drip preparation enters the blood circulation through the rectal vein.

[0023] Wherein, the osmotic pressure regulator is one of sodium chloride, boric acid, glucose and borax.

[0024] Wherein, the pH regulator is hydrochloric acid and sodium hydroxide.

[0025] The pH value and the osmotic pressure of the atomized medicinal liquid and spray medicinal liquid prepared in the present invention, the rectal administration preparation meet the requirements of the physical and chemical properties of the respiratory system and intestinal environment, and have no irritation to the respiratory tract and intestinal tract. The prepared Drugs are given to patients through corresponding medical equipment; through the above-mentioned dif...

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PUM

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Abstract

The invention discloses application of an earthworm injection in atomization and rectal administration and a preparation method, a glabrous sarcandra herb injection, an ilex pubescens injection and anosmotic pressure regulator with the mass fraction of 0.2-0.3% are added into the earthworm injection, a pH regulator is used for adjusting the pH value to 6.3-6.8, an obtained solution is prepared into an atomized inhalation preparation by ultrasonic wave or a compression type atomization machine, and the atomized inhalation preparation is directly sucked into the respiratory system in an atomized form or covers the respiratory system in a local spraying manner; and a rectal absorption promoter with the mass fraction of 0.2-0.3% is added into the earthworm injection, the pH regulator is usedfor adjusting the pH value to 6.3-6.8, an obtained solution is prepared into a rectal administration preparation, or the obtained solution is put into a dropper to prepare a rectal drop irrigation preparation, and enters the blood circulation through rectal veins. The earthworm injection conforms to the physical and chemical property requirements of the respiratory system and the environment in the intestinal tract, and has no irritation to the respiratory tract and the intestinal tract, and the operation is simple; by virtue of different preparations, the earthworm injection can be used for clinically treating various diseases.

Description

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Claims

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Application Information

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Owner 广东新峰药业股份有限公司
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