Application of earthworm injection in atomization and rectal administration and preparation method thereof
A technology of rectal administration and injection, which is applied in the field of pharmaceutical preparations and can solve problems such as reducing patient compliance, broken needles, and infections
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Embodiment 1
[0014] Add Sargassum Injection, Maodongqing Injection and an osmotic pressure regulator with a mass fraction of 0.2% to Dilong Injection, and adjust the pH value to 6.3 with a pH regulator, and use an ultrasonic or compression atomization mechanism to obtain the solution Inhalation of nebulized preparations, direct inhalation of the respiratory system in the form of nebulization or coverage of the respiratory system through local spraying;
[0015] Wherein, the osmotic pressure regulator is one of sodium chloride, boric acid, glucose and borax.
[0016] Wherein, the pH regulator is hydrochloric acid and sodium hydroxide.
Embodiment 2
[0018] Add sarcorrhizae injection, Maodongqing injection and a rectal absorption accelerator with a mass fraction of 0.25% to Dilong injection, and adjust the pH value to 6.5 with a pH regulator, and make the resulting solution into a rectal administration preparation or The resulting solution is placed in a dropper to make a rectal drip preparation, which enters the blood circulation through the rectal vein.
[0019] Wherein, the pH regulator is hydrochloric acid and sodium hydroxide.
[0020] Wherein, the rectal absorption accelerator is one of salicylate, 5-methoxysalicylic acid, surfactant, enamine and its derivatives, and fatty acid.
Embodiment 3
[0022] Add Sargassum Injection, Maodongqing Injection and an osmotic pressure regulator with a mass fraction of 0.3% to Dilong Injection, and adjust the pH value to 6.8 with a pH regulator, and put the resulting solution into a dropper to make rectal The drip preparation enters the blood circulation through the rectal vein.
[0023] Wherein, the osmotic pressure regulator is one of sodium chloride, boric acid, glucose and borax.
[0024] Wherein, the pH regulator is hydrochloric acid and sodium hydroxide.
[0025] The pH value and the osmotic pressure of the atomized medicinal liquid and spray medicinal liquid prepared in the present invention, the rectal administration preparation meet the requirements of the physical and chemical properties of the respiratory system and intestinal environment, and have no irritation to the respiratory tract and intestinal tract. The prepared Drugs are given to patients through corresponding medical equipment; through the above-mentioned dif...
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