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Inhalation powder mist preparation for preventing and treating respiratory tract infectious diseases

A technology for infectious diseases, respiratory tract, used in the medical field

Pending Publication Date: 2021-08-13
BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] However, there is currently no report on the use of active iodine molecules for the prevention and treatment of respiratory and lung-related diseases, especially the use of active iodine molecules for the prevention and treatment of lower respiratory tract and lung infectious diseases through inhalation

Method used

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  • Inhalation powder mist preparation for preventing and treating respiratory tract infectious diseases
  • Inhalation powder mist preparation for preventing and treating respiratory tract infectious diseases
  • Inhalation powder mist preparation for preventing and treating respiratory tract infectious diseases

Examples

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Effect test

preparation example 1

[0056] Preparation example 1. the preparation of cediodine

[0057] Cediiodine can be prepared by existing technologies, such as Chinese patent 90106682.6, and can also be prepared by the following process:

[0058] 1. Sidi iodine composition: iodine 3.0g; potassium iodide 2.0g; β-cyclodextrin 12.5g; purified water 56.0g.

[0059] 2. Preparation process

[0060] (1) Weigh potassium iodide, add 3 times the amount of purified water, and stir to dissolve. Add iodine, water bath at 50°C, stir to dissolve, set aside.

[0061] (2) Weigh β-cyclodextrin, place it in a suitable container, add 4 times the amount of purified water, and stir at 80°C to dissolve it all.

[0062] (3) Drop the iodine solution in (1) into the β-cyclodextrin aqueous solution, maintain the temperature of the water bath at 80°C, continue to stir for 2 hours, take it out and let it stand at room temperature for 1 day, filter under reduced pressure, and wash with purified water 3 times. After draining the wate...

preparation example 2

[0064] 1. Composition of cediodine inhalation powder.

[0065] Table 1

[0066] composition content Cediiodine (calculated as iodine) 0.05g inhaled lactose 20.0g

[0067] 2. Preparation process

[0068] (1) The prepared cediodine is pulverized by a jet mill to control its particle size D90<5 μm.

[0069] (2) Weigh cediodine and lactose, mix evenly, fill capsules or use multi-dose storage type inhalation device for filling, to get ready.

preparation example 3

[0071] 1. Composition of cediodine inhalation powder.

[0072] Table 2

[0073] composition content Cediiodine (calculated as iodine) 1.0g inhaled lactose 20.0g

[0074] 2. Preparation process

[0075] (1) The prepared cediodine is pulverized by a jet mill to control its particle size D90<5 μm.

[0076] (2) Weigh cediodine and lactose, mix evenly, fill capsules or use multi-dose storage type inhalation device for filling, to get ready.

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Abstract

The invention relates to an inhalation powder mist preparation for preventing and treating respiratory tract infectious diseases. Specially, the invention relates to an inhalation preparation for preventing and treating respiratory tract infectious diseases, in particular to an inhalation powder mist preparation. The inhalation powder mist preparation comprises iodine molecules as an active substance and / or a pharmaceutically acceptable carrier. The medicine is inhaled into the respiratory tract or the lung through powder mist for preventing and treating infectious diseases of the respiratory tract and the lung, and has the advantages of direct targeting action on infected parts, quick response, small dosage and small side effect. Various pathogens in the respiratory tract can be rapidly killed, and the purposes of reducing infectivity, relieving pain of a patient, shortening the rehabilitation period, improving the cure rate, reducing complications and reducing the death rate are achieved.

Description

[0001] This application claims the priority of the Chinese patent application (name: a dry powder inhalation preparation for the prevention and treatment of respiratory infectious diseases; application number 2020100825781) submitted on February 07, 2020. technical field [0002] This application relates to the field of medicine. More specifically, it relates to an inhalation powder mist preparation for preventing and treating respiratory infectious diseases, and its use in treating infectious diseases. Background technique [0003] Respiratory infectious diseases are a serious threat to human health. This disease is usually caused by pathogenic microorganisms entering the body through the respiratory tract such as the nasal cavity, throat and trachea, thereby causing related infectious diseases. Respiratory infectious diseases are characterized by very rapid spread and wide spread. Once the disease spreads, it is difficult to control and seriously endangers human life and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18A61K31/79A61K31/198A61K9/72A61K9/12A61K47/69A61P11/00A61P11/04A61P31/16A61P31/14A61P31/04A61P31/10A61P31/22A61P31/20
CPCA61K33/18A61K31/79A61K31/198A61K9/0073A61K9/12A61K47/6951A61P11/00A61P11/04A61P31/16A61P31/14A61P31/04A61P31/10A61P31/22A61P31/20A61K2300/00Y02A50/30
Inventor 姜庆伟梁希刘珍珍陈丹颜琨甘艳秋刘华杨文斌高永良
Owner BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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