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Pharmaceutical composition for treating viral infection of respiratory system

A viral infection and respiratory system technology, which is applied in the field of pharmaceutical compositions for the treatment of respiratory viral infections, can solve problems such as inability to assemble into viruses, and achieves the advantages of inhibiting pulmonary viral infections, fast onset of action, and reduced dosage. Effect

Inactive Publication Date: 2021-02-23
徐静 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the mechanism of chloroquine's inhibition of SARS virus is not completely clear, the author believes that the inhibitory effect is mainly achieved through two pathways. One mechanism is that chloroquine inhibits the receptor on cells that can bind to SARS virus, that is, the angiotensin 2 receptor (ACE2). Another mechanism is to increase the pH of the cell lysosome to change the external environment of the virus, so that the protein and nucleic acid cannot be assembled into a complete virus

Method used

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Examples

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Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: preparation method of pharmaceutical composition of the present invention

[0053] Composition: Chloroquine Phosphate 1.0g, Acetylcysteine ​​0.333g.

[0054] Preparation method: (1) Add sodium methylparaben and sodium propylparaben into purified water, stir to dissolve. (2) Add chloroquine phosphate and acetylcysteine ​​to the above solution to dissolve evenly. (3) Adjust the pH value to 4.0~5.0 with a small amount of triethanolamine. (4) Divide the above mixture into special containers with a spray device to prepare a spray containing the composition of chloroquine phosphate and expectorant medicine.

Embodiment 2

[0055] Embodiment 2: preparation method of pharmaceutical composition of the present invention

[0056] Composition: Chloroquine Phosphate 1.0g, Acetylcysteine ​​0.667g.

[0057] Preparation method: (1) Take chloroquine phosphate, acetylcysteine ​​and mannitol, add water for injection, stir to dissolve. (2) Adjust the pH value to 4.0~5.0 with a small amount of sodium hydroxide. (3) The above-mentioned solution is divided into vials, freeze-dried to form a sterile block, and then a sterile powder for injection containing chloroquine phosphate and an expectorant drug composition is obtained.

Embodiment 3

[0058] Embodiment 3: preparation method of pharmaceutical composition of the present invention

[0059] Composition: Chloroquine Phosphate 1.0g, Acetylcysteine ​​1.0g.

[0060] Preparation method: (1) Take benzyl alcohol, chloroquine phosphate, and acetylcysteine, add it to pure aqueous solution, and stir to dissolve evenly. (2) Adjust the pH value to 4.0~5.0 with a small amount of triethanolamine. (3) The above mixed liquid is divided into special containers with spraying devices, and propellant tetrafluoroethane is added to prepare an aerosol containing chloroquine phosphate and expectorant drug composition.

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating viral infection of respiratory system. The pharmaceutical composition contains chloroquine and a sputum-removing drug. The sputum-removing drug is selected from at least one of acetylcysteine, ambroxol or ammonium chloride. The invention provides a preparation method of the pharmaceutical composition for preventing and treating diseases caused by virus infection of a human respiratory system. The medicine composition of the chloroquine and sputum-removing drug is prepared into a spray, an aerosol or an inhalation preparation forpreventing and treating the diseases caused by the virus infection of the human respiratory system.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating diseases caused by human respiratory virus infection, which contains chloroquine and expectorant drugs, and the specific application form is: preparing chloroquine and expectorant drugs into injections, sprays, and aerosols , or drug compound preparations such as inhalation preparations. It is used to prevent and treat diseases caused by human respiratory virus infection. Background technique [0002] Chloroquine phosphate is an old anti-malarial drug that has been on the market for more than 60 years. Its dosage forms include oral administration and intravenous administration. We have been paying attention to the report on the antiviral effect of chloroquine, and found that since 1969, the antiviral effect of chloroquine in vitro has been reported successively after searching the literature. [0003] (1) New Castle Virus: In 1969, British Ingot et al. first reported th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4706A61K45/06A61K31/198A61K31/137A61K33/02A61K9/72A61K47/26A61K47/10A61K47/20A61K47/22A61P31/14A61P11/00
CPCA61K9/0078A61K31/137A61K31/198A61K31/4706A61K33/02A61K45/06A61K47/10A61K47/20A61K47/22A61K47/26A61P11/00A61P31/14A61K2300/00
Inventor 张艳红曲福军徐光昳王绿江
Owner 徐静
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