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Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid

A technology of corticosteroids, preparations, applied in the field of treatment of lung diseases and disorders

Active Publication Date: 2007-06-06
CYDEX PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And the prior art does not suggest that one cyclodextrin-corticosteroid inhalable formulation would be advantageous over another cyclodextrin-corticosteroid inhalable formulation

Method used

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  • Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
  • Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
  • Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid

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Abstract

An inhalable formulation containing SEA-gamma-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-gamma-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.

Description

Inhalation formulations containing sulfoalkyl ether cyclodextrins and corticosteroids Inventors: JamesD.Pipkin, RupertO.Zimmerer, DianeO.Thompson, GeroldL.Mosher technical field The present invention relates to a method and formulation for administering sulfoalkyl ether cyclodextrins and corticosteroids such as budesonide by inhalation. The present invention also relates to methods of treating pulmonary diseases and conditions. Background technique Drug delivery by inhalation results in drug deposition in various parts of the respiratory tract, such as the throat, trachea, bronchi, and alveoli. In general, the smaller the particle size, the longer the particles remain suspended in the air, so the drug can be delivered deeper into the respiratory tract. Corticosteroids are delivered by inhalation using a nebulizer, metered dose inhaler, or dry powder inhaler. The main advantages of nebulizers are that they do not require patient cooperation and are simpler to deliver hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K45/06C08B37/16A61K9/00A61K9/08A61K9/14A61K31/16A61K31/57A61K31/715A61K47/40A61K47/48
CPCA61K9/0078A61K31/16A61K47/48969A61K31/57A61K47/40A61K31/715B82Y5/00A61K9/08A61K9/0075A61K31/573A61K47/6951A61K31/137A61K31/167A61K31/46A61K31/56A61K31/58A61P11/00A61P11/06A61P29/00A61P43/00A61K2300/00A61K9/00
Inventor 詹姆斯·D.·皮普金鲁珀特·O.·齐默勒戴安娜·O.·汤普森格罗尔德·L.·莫舍
Owner CYDEX PHARMACEUTICALS INC
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