The invention discloses snakegourd fruit juice which is made of raw materials comprising, by weight, 50-70 parts of snakegourd peel and snakegourd pulp mixtures, 15-20 parts of hawthorns, 15-20 parts of pomegranates, 3-5 parts of banana skin, 5-10 parts of dragon fruit, 1-3 parts of pectinase, 0.5-4 parts of citric acid, 400-500 parts of yoghourt, 3-8 parts of honey, 0.7-2.2 parts of sodium carboxymethylcellulose, 0.5-0.8 part of potassium sorbate and appropriate pure water. The snakegourd peel and the snakegourd pulp mixtures are taken as the main raw materials added with the hawthorns, the pomegranates, the banana skin and the dragon fruit, cane sugar is replaced by the honey, takes of the snakegourd fruit juice is improved, and functions in relieving heavy metal poisoning, appetizing, cleaning lung and eliminating phlegm, promoting flow of qi and relieving chest stuffiness, speeding up metabolism, preventing aging, whitening skin, losing weight, moistening the intestines and preventing colon cancer are achieved. The peel, the pulp and seeds of the banana skin and the dragon fruit are utilized, waste of the raw materials is avoided, and production cost is lowered. In addition, the preparation method is simple and low in production cost.