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Application of low molecular citrus pectin in clinic lead discharge and heavy metal discharge

A heavy metal, low molecular technology, applied in application, food preparation, food science and other directions, can solve the problem that natural citrus pectin does not have very effective functions in the human body

Inactive Publication Date: 2011-01-05
范晓青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some are fermented in the large intestine, natural citrus pectin is generally not very effective for the human body

Method used

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  • Application of low molecular citrus pectin in clinic lead discharge and heavy metal discharge
  • Application of low molecular citrus pectin in clinic lead discharge and heavy metal discharge
  • Application of low molecular citrus pectin in clinic lead discharge and heavy metal discharge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Lead poisoning is an ongoing global concern, and children are the most vulnerable to the long-term effects of lead exposure. There is an urgent need for a safe and effective heavy metal chelator to overcome heavy metal and lead exposure, the challenges they face every day.

[0028] Objective 1: This clinical study was conducted to determine whether oral administration of low molecular weight citrus pectin is effective in reducing blood lead toxicity in children aged 5 to 12 years.

[0029] METHODS: Hospitalized children with serum lead levels above 20 μg / dL as determined by graphite furnace atomic absorption spectrometry were not given any chelating and / or detoxifying drugs within the first 3 months, and 15 g of low-molecular-weight citrus pectin per day , divided into 3 times to give. Serum from day 0, day 14, day 21, and day 28 and urine from day 24 were collected for graphite furnace atomic absorption analysis.

[0030] RESULTS: The present study showed a sharp decr...

Embodiment 2

[0052] This clinical study was conducted to determine whether oral administration of low molecular weight citrus pectin is effective in reducing heavy metal toxicity in adult urine.

[0053] 1 Effect of low molecular weight citrus pectin on the excretion of toxic elements in urine:

[0054] method:

[0055] 10 patients took 15 grams of low-molecular-weight citrus pectin per day for 7 days, and 20 grams on the 8th day

[0056] Urine samples were collected for 24 hours for measurement: Day 0, Day 1, Day 7.

[0057] The following elements were analyzed by inductively coupled plasma mass spectrometry (ICP-MS): calcium, magnesium, zinc, aluminum, arsenic, cadmium, calcium, mercury and lead.

[0058] result;

[0059] Such as Figure 5 As shown, urinary arsenic excretion was significantly increased in the first 24 hours (35% over mean baseline (day 0); p<0.05), and mercury and cadmium excretion was significant (55% and 135%; p<0.1)

[0060] Such as Figure 6 As shown, on day ...

Embodiment 3

[0062] Example 3 Effect of low molecular weight citrus pectin on the burden of mercury in the body for a long time

[0063] method:

[0064] Human clinical trials study 8 patients

[0065] Total body mercury baseline determination is the method of choice using dimercapto-1-propanesulfonic acid (DMS).

[0066] The daily oral dose of low molecular weight citrus pectin is 15 grams,

[0067] Determination of total body mercury by the same dimercaptan selection method after treatment with low molecular weight citrus pectin.

[0068] result:

[0069] Daily intake of 15 grams of citrus pectin Table Description:

[0070]

[0071] Summary of the results of low molecular weight citrus pectin in reducing mercury levels in the body

[0072] All subjects showed a significant decrease in mercury levels. The average decrease was 72.17%, the range was 38.13%-84.83% (P=0.0313), and there was no side effect.

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Abstract

The invention relates to a new application of low molecular citrus pectin, in particular to the application of low molecular citrus pectin for treating and preventing lead and heavy metal poisoning in prepared medicines, foods and health care products. The low molecular citrus pectin is a compound prepared from soluble dietary fiber and galacturonic acid, the polysaccharide derivative is used as a metal ion absorbent (chelating agent), has absorption action on heavy metal ions, can remove heavy ions, such as Zn2+, Cu2+, Cd2+, Ag+, Cr3+, Ni2+, Hg2+, Pb2+ and the like. The low molecular citrus pectin is different from common chemical chelating agents; proved by animal and clinic experiments, lead, mercury and arsenic are discharged out of human bodies during toxin discharge, and the key level of calcium, magnesium, zinc or other minerals can not be influenced. The natural chelating function of the low molecular citrus pectin is a most ideal and successful solution for heavy metal pollution in the human body at present. Thus, the low molecular citrus pectin has the function of preventing various diseases and especially has special functions of clearing away harmful cells and discharging toxins in the human body.

Description

technical field [0001] The invention relates to a new application of low-molecular citrus pectin, in particular to the application of low-molecular citrus pectin in the treatment and prevention of lead and heavy metal poisoning in prepared medicines, food and health care products. Background technique [0002] Natural citrus pectin is a polysaccharide complex (long-chain carbohydrate) and a dietary fiber. It is obtained from the peel and pulp of natural citrus fruits such as lemons, grapefruits, oranges and tangerines. The long-chain product of this polysaccharide has many branches and has the function of adhesion. Natural pectin is a soluble fiber that cannot be absorbed by the intestine after consumption. Although some are fermented in the large intestine, natural citrus pectin is generally not very effective for the human body. [0003] Low molecular weight citrus pectin, its structural formula is as follows: [0004] [0005] Low-molecular citrus pectin is a polys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/732A61P39/04A23L1/30A23L1/308A23L33/125A23L33/22
Inventor 范晓青俞仲华
Owner 范晓青
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