147 results about "Drug side effect" patented technology

The present invention is directed to a combination treatment of an opioid antagonist e.g., naltrexone and a second compound selected from the group consisting of a GABA B agonist, an NMDA antagonist, a serotonin antagonist, and a cannabinoid antagonist is the key to the successful treatment of a brain reward system disorder. A brain reward system, include but are not limited, to pathological gambling, compulsive alcohol consumption, compulsive over-eating and obesity, compulsive smoking, and drug addiction. The compounds and methods of the present invention effectively reduce the cravings, withdrawal symptoms and negative drug side effects associated with a monotherapy. As such, patient compliance is greatly increased, thereby decreasing relapse of a brain reward system disorder.

The present invention provides drug therapy formulations for reducing the side effects associated with a therapeutic. In some embodiments, the present invention provides a reduction in sleep- and diet-related side effects associated with a therapeutic.

The invention discloses a compound camellia oil preparation which takes camellia oil as a main component and is a health-care food with mentality improving and blood lipid lowering effects. The preparation mainly comprises the components in percentage by weight: 80-95% of camellia oil, 4-20% of safflower oil and 0.01-1% of natural antioxidant, wherein the sum of the content of the components is 100%. The preparation with the mentality improving and blood lipid lowering effect is put forward by adopting food and nutrients according to the principle of homology of medicine and food, takes the camellia oil as a main component and the safflower oil as an auxiliary material, has obvious blood lipid lowering effect and mentality improving effect to a certain degree and reduces drug side-effects.

A system for the capture, management or use of patient medical and prescription data is disclosed. In some illustrative embodiments, the system includes: a computer system including at least one server computer and at least one physician computer in communication with said at least one server over a network, such as the Internet; wherein said at least one server computer includes a database of drug side effects, interactions or contraindications, which are accessible via said at least one physician computer via a graphical user interface.

The invention relates to a medicinal composition of ambroxol in a non-salt form. Particularly, the invention especially relates to a composition comprising ambroxol in a base form and other oral substances with or without physiological activity or a drug container. The inventor surprisingly finds that when ambroxol is prepared into an oral preparation in a non-salt form, and especially a preparation such as a suspension, a dry suspension, a granule and the like needing to be diluted and prepared with water before drinking, the mouthfeel is significantly improved when compared with that of an ambroxol hydrochloride solution, and the ambroxol preparation has significantly slower absorption in vivo than an ambroxol hydrochloride preparation; and the realization of a slow-release effect which requires great effort on preparation process can be easily achieved. It is well known that the slow release of a drug can reduce drug side effects and increase security with the guarantee of curative effects.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a therapeutically effective amount of ceruloplasmin or a functional derivative thereof. The neuroprotective composition is characterized in that it protects neuronal cells from reactive oxygen species such as .O2- and .OH. In a preferred embodiment, the neuroprotective composition further comprises an antioxidant consisting of catalase or of an amphiphilic physiological antioxidative solution comprising a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

The invention relates to a traditional Chinese medicine external rubbing preparation for hair growth and black hair, which belongs to the field of traditional Chinese medicine for external use. It is a type A extract prepared by immersing 6% of Baibu, 6% of Eclipta, 6% of Polygonum multiflorum, and 12% of side louver into ethanol. Psoralen 11.6% was immersed in ethanol to obtain type B extract, 4% peach kernel, 4% safflower, and peppermint were immersed in ethanol to obtain type C extract, and then A, B, and C were mixed with each other. Mix and store in an airtight container for 30 days. The preparation does not contain any chemical components harmful to the human body, and can make the hair of alopecia patients grow rapidly and the hair of patients with white hair turn black. The problem of large side effects, insignificant curative effect and long treatment time of the currently used medicines for treating hair loss and white hair is solved. The liniment is simple to use and low in production cost, and is suitable for various hair loss patients and middle and early gray hair patients.

The invention relates to laser medical products and discloses a combination laser therapy apparatus which comprises a laser device with the wavelength of 1064nm, a laser device with the wavelength of 650nm, a Cr4 + Q-switching switch system, a light path transmission system, a laser power supply, an infrared temperature measurement system, a cooling circulating system, a master control system and a display touch screen. The laser device with the wavelength of 650nm is located in the direction of output light of the laser device with the wavelength of 1064nm. The light path transmission system is located on the output light path of the laser device with the wavelength of 650nm. The master control system is connected with the laser power supply, the infrared temperature measurement system, the cooling circulating system, the display touch screen and the Cr4 + Q-switching switch system, and the cooling circulating system is connected with the laser power supply. Laser of the combination laser therapy apparatus can directly reach a fungal infection site, heats fungus and enables the fungus to be deprived of ability of replication and reproduction, and therefore the therapy purpose is achieved. The combination laser therapy apparatus has the advantages of being high in cure rate, low in recurrence rate and free of drug side effects.

The invention discloses a device for treating epilepsia, comprising at least one electric potential monitoring electrode and a corresponding voltage amplifying circuit, at least one current electrode and a corresponding voltage clamp circuit, and a voltage analysis and control circuit and a power circuit, wherein the electric potential monitoring electrode is connected with an input terminal of the voltage analysis and control circuit by the power amplifying circuit, the current electrode is connected with an output terminal of the voltage analysis and control circuit through the voltage clamp circuit and the power circuit provides working power for all the circuits. The device of the invention applies no medicine and causes no drug side-effect to patients when carrying out treatment, does not need to damage the brain nervous system, can avoid causing severe damage to the nervous system of human brain, affecting the functions of the nerve centre; and in addition, with the device, stopping the ongoing treatment is convenient, the structure of the nervous system prior to treatment can be restored and treatment safety is high.

The invention relates to a composite sunflower composition for reducing uric acid and alleviating gout and a preparation method and application of the composite sunflower composition, and belongs to the technical field of functional foods. In order to solve the problems that a conventional gout treatment drug is small in side effect, complex in components and the like, through methods of extraction, enzymolysis, molecular weight interception and the like, a preparation method of a sunflower extract, a preparation method of a coix seed extract and a preparation method of a lophatherum herb extract are optimized, and the obtained extracts are rich in effective components of micromolecule weight active glycoconjugate, flavone, alkaloid and the like. The invention further provides the composition consisting of 80-120 parts by weight of the sunflower extract, 10-30 parts by weight of the coix seed extract, 5-15 parts by weight of the lophatherum herb extract and 50-70 parts by weight of themaltodextrin and a preparation method of the composition. The invention can be used for development of health-care products and drugs for improving the gout and / or hyperuricaemia.

The invention relates to the technical field of medicines, particularly to scopolamine hydrobromide orally disintegrating microencapsule tablets based on a NiMS system and a preparation method thereof. The orally disintegrating microencapsule tablet provided by the invention is prepared by the NiMS system containing scopolamine hydrobromide and auxiliary materials. The auxiliary materials comprise microcrystalline cellulose, sodium carboxymethyl starch, mannitol, lactose, xylitol, magnesium stearate, superfine silica powder, etc. The copolamine hydrobromide orally disintegrating microencapsule tablet provided by the invention can be taken conveniently, and disintegrated rapidly in mouth by solvent of saliva without needing to drink water. The NiMS system further has a slow release effect,thereby not causing abnormal high blood drug concentration, reducing drug side effects, reducing local stimulation, and meeting requirements for special conditions and special groups, particularly the aged, children and patients who swallow difficultly.

The invention belongs to the technical field of biomedical text mining. The invention discloses a drug pathogenic relationship extraction method based on domain knowledge. The method comprises the following steps: (1) processing a drug pathogenic relationship data set; (2) constructing a domain knowledge set; (3) constructing an entity-relationship graph according to the domain knowledge; (4) completing vector representation of the words in the example; (5) building a KB-GCN neural network model. The drug pathogenic relationship extraction method based on domain knowledge is practicable and clear in structure and has reference value. The method is suitable for automatically identifying the drug pathogenic relationship from a biomedical text by applying domain knowledge in a database, and is helpful for constructing a drug pathogenic database, assisting drug side effect prediction and the like.

The invention discloses a urate oxidase gene recombinant plasmid and a genetic engineering bacterium which produces urate oxidase. The urate oxidase gene recombinant plasmid pRNJ800-U is obtained by inserting a NisA+MCS fragment and a urate oxidase gene in a plasmid vector pRAF800. The recombinant plasmid pRNJ800-U is transformed into Lactococus lactis to obtain the genetic engineering bacterium which produces the urate oxidase. The genetic engineering bacterium can be prepared into a biological preparation for oral administration to ensure that the genetic engineering bacterium is colonized on intestinal mucosa, thereby persistently and effectively decomposing uric acid in an intestinal canal to prevent and treat various diseases related to high uric acid; thus the side effect of drugs can be avoided, and the frequent drug use is also not needed. At the same time, the Lactococus lactis is a probiotic bacterium of the intestinal canal of a human body, is colonized on an inner layer of the intestinal mucosa, has functions of strengthening immunosuppresive pathogen, synthesizing various vitamins, reducing cholesterol and so on, and has a plurality of health care functions.

A computational systems pharmacology framework consisting of statistical modeling and machine learning based on comprehensive integration of systems biology data, including drug target data, protein-protein interaction (PPI) networks, and gene ontology (GO) annotations, and reported drug side effects, can predict drug toxicity or drug adverse reactions (ADRs). Biomolecular network and gene annotation information can significantly improve the predictive accuracy of ADR of drugs under development. The use of PPI networks can increase prediction specificity, and the use of GO annotations can increase prediction sensitivity.

The invention discloses a compound flavescens cleaning yin flushing liquid, which is characterized in that it is made of the following traditional Chinese medicines in proportions by weight: flavescens, cnidium, rhubarb, atractylodes, Morinda officinalis, Smilax cocos, white moss bark, Phellodendron cortex, coix seed, Kochia scoparia, saponins, safflower, dried alum. Pure natural Chinese herbal medicine is selected, formulated according to the theory of traditional Chinese medicine, after strict screening, processed separately, and combined with modern advanced technology. The preparation is made of pure Chinese herbal medicine, has little toxic and side effects, treats both symptoms and root causes, has remarkable curative effect, clinical symptoms disappear quickly, and there is no rebound phenomenon after being cured. Indications include senile vaginitis, trichomonas vaginitis, fungi, gonorrhea, bacteria and mycoplasma and chlamydia cervicitis, vaginal ulcers, menopausal vaginal dryness and other women's reproductive system diseases.

A system and method for analyzing chemical data including a processor and one or more classifiers, stored in memory and coupled to the processor, which further includes an indication predictive module configured to predict whether a given chemical treats a particular indication or not and a side effect predictive module configured to predict whether a given chemical causes a side-effect or not. A correlation engine is configured to determine one or more correlations between one or more indications and one or more side effects for the given chemical and a visualization tool is configured to analyze the one or more correlations and to output results of the analysis.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

The invention discloses a controllable release system of glucocorticoid, the preparing method and the application. The controllable release sytem is the glucocorticoid microcapsule, uses natural biodegradable high-molecular material as the base material of glucocorticoid drug, and adopts ultrasonic micro-capsulizating technique of combination of emulsification and mechanical mixing to wrap the drug in the microsphere composed of the base material to make microcapsule; further prepare the drug's powder, capsule, plaster, tablet and injection or pill, able to effectively control the release rate and stability of the drug, maintain the needed blood concentration, and on the premise of assuring the cure effect, largely reduce the frequency of dosing or injecting and the side effect of the drug.

The invention discloses an FISH probe set for detecting NTRK fusion and application thereof. The set comprises a NTRK1 5' end probe set, a NTRK1 3' end probe set, a NTRK2 5' end probe set, a NTRK 2 3'end probe set, a NTRK3 5' end probe set and a NTRK3 3' end probe set. The set has the advantages of rapid and simple operation, accurate and reliable detection results and accurate detection of all fusion types of NTRK1, NTRK2 and NTRK3 genes, provides a reference for the treatment of tumor patients, is beneficial to individualized targeted therapy, reduces drug side effects, improves quality oflife of patients, reduces the burden on families and society, and is suitable for large-scale promotion and application.

The invention discloses a compound preparation for treating cecal granuloma and a preparation method thereof. The compound preparation comprises chloroquine phosphate, diiodohydroxyquinoline, chlorogenic acid, liquiritin, cistanoside, ursolic acid, polysavone, levamisole, albendazole, okra powder, lactein, vitamin B1, lactalbumin and arginine. The compound preparation can effectively expand intestinal tubes, prevent intestinal obstruction, prevent mesentery and intestinal wall inflammatory infiltration and edema, prevent intestinal wall fibrosis, adjust body metabolism, improve immunity, reduce drug side effects and treat cecal granuloma and has a wide application prospect.

The invention provides traditional Chinese medicine for treating dental ulcer. The traditional Chinese medicine for treating dental ulcer is prepared by, by weight, raw materials including 10-20 parts of honeysuckles, 10-20 parts of asarum powder, 10-20 parts of puffball, 10-20 parts of borneols, 5-10 parts of indigo naturalis, 20-50 parts of pseudo-ginseng, 10-30 parts of isatis root, 5-15 parts of golden cypress, 10-20 parts of liquorice, 10-30 parts of mirabilitum praeparatum, 10-20 parts of radix angelicae, 5-10 parts of steviosin, 10-30 parts of jasmine, 5-10 parts of menthol and 10-30 parts of dandelion. The traditional Chinese medicine has remarkable effect of quickly treating the dental ulcer and is free of drug side effects, and the dental ulcer does not relapse after being cured.

The invention discloses a traditional Chinese medicine for harmonizing liver and spleen, dispelling wind and eliminating dampness and nourishing blood and stopping throat pains. The traditional Chinese medicine is prepared from the following raw materials by weight: primary materials including 10g-30g of caulis sinomenii, 15g-30g of sarcandra glabra, 15g-30g of white paeony root, 15g-25g of Chinese angelica, 9g-20g of rhizoma atractylodis, 6g-15g of divaricate saposhnikovia root, 15g-20g of roasted rhizoma atractylodis macrocephaiae and 6g-15g of ligusticum wallichii, and auxiliary materials including 6g-15g of raw liquorice. The traditional Chinese medicine disclosed by the invention has the whole set of treatment effects of regulating the function of the liver and spleen, dispelling wind and eliminating dampness, nourishing blood and relieving throat pains, and the like, is especially suitable for patients with rheumatic disease (rheumatoid arthritis, and the like) symptoms such as muscular soreness, arthrocele, pain, inconvenient flexing and stretching, numb and stiffness, weakness, and the like. Moreover, the traditional Chinese medicine is integrated with treating and healthy qi-supporting, can be used for effectively improving the immunity of the body while treating the diseases, and effectively solving the problems such as great drug side effect, great injuries on body and poor treatment effect, of the existing bi-syndrome treatment.

The invention discloses a fat-reducing traditional Chinese medicine. The fat-reducing traditional Chinese medicine is characterized by being prepared from the following components in parts by weight: 15-20g of cassia seeds, 25-35g of hawthorns, 25-30g of malts, 5-8g of tea leaves, 5-8g of lotus leaves, 5-8g of dried tangerine or orange peel, 8-18g of poria cocos and 10-15g of selfheal. A preparation method of the fat-reducing traditional Chinese medicine comprises the following steps: getting and placing cassia seeds, hawthorns and malts into a pot, adding water and decocting for 30 minutes; then, adding the tea leaves, the lotus leaves, the dried tangerine or orange peel, the poria cocos and the selfheal to cook for 10 minutes, pouring out decoction for later use; re-adding water, decocting, getting juice, mixing the decoctions obtained twice, and filling into a warm bottle for later use, wherein the product can be drunk as tea, one dose per day. The fat-reducing traditional Chinese medicine can be used for achieving the purpose of quickening the fat consumption, conditioning and restoring the naturalness of people, stimulating the disease resistance of people and quickening metabolism to achieve a weight-reducing purpose. The fat-reducing traditional Chinese medicine has the advantages of good weight-reducing effects, no drug side effects, health care, and the like.

The invention discloses weight-losing healthy tea. The healthy tea is prepared from, by weight, 5-15 parts of lotus leaves, 5-15 parts of cassia seeds, 5-15 parts of the root of red-rooted salvia, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of lilies, 15-25 parts of folium mori and 15-25 parts of cactus. The healthy tea has the advantages of being good in weight losing effect, free of drug side effects, convenient to prepare and low in cost, protecting health and nourishing life.

The invention provides three functional mutant recombinases of human phase II metabolic enzyme, namely, UGT2B771S, UGT2B72 and UGT2B75, wherein, a mutant site is led in a primer; a wild type gene plasmid with human UGT2B7 is taken as a template; after PCR reaction, phosphorylation, self-ligation and conversion, three functional mutant recombinase gene plasmids with the UGT2B7 are respectively synthesized. The functional mutant recombinases provided by the invention have the advantages of high level expression in insect cells, comparatively short period, exact host range of baculovirus, no human pathogenicity, safe operation, increased recombination efficiency, time saving, simple and effective construction and expression method and being easy to be amplified for mass production. The functional mutant recombinases can be applied to the screening of medicines, forecast drug side effect likely to be caused by individualized medication, thus instructing reasonable medication; the functional mutant recombinases can also be applied to the research of structure-activity relationship between enzymes and substrate drugs at molecular level.

A system and method for analyzing chemical data including a processor and one or more classifiers, stored in memory and coupled to the processor, which further includes an indication predictive module configured to predict whether a given chemical treats a particular indication or not and a side effect predictive module configured to predict whether a given chemical causes a side-effect or not. A correlation engine is configured to determine one or more correlations between one or more indications and one or more side effects for the given chemical and a visualization tool is configured to analyze the one or more correlations and to output results of the analysis.

The invention belongs to the field of traditional Chinese medicines, in particular relates to a purpose of a traditional Chinese medicine composition in preparing a medicament for treating diabetic retinopathy and aims at solving the deficiencies in the prior art that the traditional chemical treatment medicament for the diabetic retinopathy is large in hepatotoxicity and poor in curative effect. The traditional Chinese medicine composition for treating or preventing the diabetic retinopathy is mainly prepared from the following medicinal raw materials in parts by weight: 17 parts of astragaloside, 16 parts of desertliving cistanche, 10 parts of rhizoma smilacis glabrae, 12 parts of Chinese arborvitae twig, 8 parts of rhizoma alismatis, 9 parts of rhizoma coptidis, 10 parts of prepared rehmannia root, 8 parts of gentian, 18 parts of bighead atractylodes rhizome, 16 parts of dandelion, 8 parts of pinellia ternate, 8 parts of gardenia, 10 parts of virgate wormwood herb and 18 parts of licorice. The traditional Chinese medicine composition is good in curative effect of treating or preventing the diabetic retinopathy, is low in side effect of the medicament and has remarkable clinical popularization value.

The invention discloses a drug for treating chronic dyspepsia. The drug is characterized by comprising the following components by weight: 20g of rhizoma atractylodis macrocephalae, 20g of poria cocos, 15g of rhizoma atractylodis, 15g of cortex magnoliae officinalis, 15g of pericarpium citri reticulatae, 10g of rhizoma cyperi, 10g of radix ginseng, 10g of amomum fructus amomi rotundus, 10g of radix aucklandiae, 10g of fructus amomi, 10g of radix liquiritiae and 10g of fructus jujubae. According to a method for preparing and taking the drug, a dose of the drug is taken warmly each day, the radix ginseng can be separately decocted and taken together with the drug, and the rhizoma cyperi is decocted afterwards. The drug solves the problems of great side effect, long taking time, high relapse rate after drug withdrawal, incapability of radically treating chronic dyspepsia and the like for an existing drug for treating chronic dyspepsia, and is suitable for treating the chronic dyspepsia.

A compound antithyroid gel for external application comprises an antithyroid drug, adrenal glucocorticoid, and a drug penetration enhancer. When in use, the gel is directly and externally applied to skin at the anterior cervical thyroid site. The drug directly penetrates into thyroid through skin to treat hyperthyroidism; the using amount of the drug is less; the curative effect is quick; and no systemic drug side effect is caused to human body. When the compound antithyroid gel of the invention is used for the treatment of hyperthyroidism, the repeated incidence and recurrence incidence of hyperthyroidism are low; the treatment effect is improved; and patient pain is relieved. The compound antithyroid gel is a safer and more effective drug for treating hyperthyroidism.