30 results about "Dimethylbenzimidazole" patented technology

The invention describes a pharmaceutical composition and method for treating cancer comprised of A) 2,3-dimethoxy-5-methyl-1,4-benzoquinone and/or B) at least one of wild yam root, teasel root, balm of gilead bud, bakuchi seed, dichroa root, kochia seed, kanta kari, bushy knotweed rhizome, arjun, babul chall bark, opopanax and bhumy amalaki; optionally one or more of frankincense, garcinia fruit, vitex, dragons blood, mace, sage and red sandalwood with at least c) one compound capable of maximizing oxidative mitochondrial function preferably riboflavin or vitamin B₂ derivatives, FAD, FMN, 5-amino-6-(5′-phosphoribitylamino)uracil, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin, vitamin B₁, lipoic acid, biotin, vitamin B₆, vitamin B₁₂, folate, niacin, vitamin C and pantothenate and/or d) at least one lactic acid dehydrogenase inhibitor (preferably 2′,3,4′5,7-pentahydroxyflavone) and optionally f) an alkalizing agent (aloe vera, chlorella, wheat grass, sodium or potassium bicarbonate, potassium) g) an antiproliferative herb (speranskia or goldenseal) and h) a pharmaceutically acceptable carrier.

The invention describes a nutraceutical composition and method for preventing/treating cancer comprised of A) quinones (2,3-dimethoxy-5-methyl-1,4-benzoquinone, thymoquinone, tocopherolquinone) B) compounds capable of maximizing oxidative mitochondrial function preferably riboflavin, FAD, FMN, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin, vitamin B₁, lipoic acid, biotin, vitamin B₆, vitamin B₁₂, folate, B3, C and pantothenate C) lactic acid dehydrogenase inhibitors; 2′,3,4′5,7-pentahydroxyflavone, epigallocatechin gallate, quercetin, citric acid, rosemary, black walnut, clove, nutmeg, licorice root, coriander, cinnamon, ginger root, myrrh gum and green tea D) alkalizing agents: aloe vera, chlorella, wheat grass, apple cider vinegar, burdock root, kudzu root, alfalfa, barley grass, spirulina, parsley leaf, calcium, magnesium, potassium or bicarbonate salts E) potent tumoricidal herbs; gromwell root, wild yam, beth root, teasel root, balm of gilead bud, frankincense, bakuchi seed, dichroa root, kochia seed, kanta kari, sweet myrrh, galbanum, garcinia fruit, mace, white sage and tumoricial plant derived constituents: gambogic acid, shikonin, diosmin or boswellic acid F) an antiproliferative herb (speranskia or goldenseal) and G) a pharmaceutically acceptable carrier.

The invention discloses a 5-substituted dihydrobenzofuran-imidazolium salt compound and a preparation method thereof. The preparation method comprises the following steps of: performing Vilsmeier reaction by taking 2,3-dihydrobenzofuran as a raw material, thereby synthesizing 5-carboxaldehyde dihydrobenzofuran, reducing the 5-carboxaldehyde dihydrobenzofuran into 5-benzyl alcohol substituted dihydrobenzofuran in an alcohol by using sodiumborohydride, and then converting the 5-benzyl alcohol substituted dihydrobenzofuran into methanesulfonate, next, carrying out a reflux reaction between the methanesulfonate and imidazolium or benzimidazole in a solvent, thereby synthesizing 1-(substituted dihydrobenzofuran) imidazolium, and finally, on the basis, reacting the 1-(substituted dihydrobenzofuran) imidazolium with a halide to synthesize the 5-substituted dihydrobenzofuran-imidazolium salt compound. According to the invention, a pharmacophore with remarkable anti-tumor activity in a natural product is used as a precursor and then design and synthesis of anti-tumor medicine molecules are carried out, and consequently, the synthesized compound has excellent in-vitro anti-tumorous cytotoxin activity. Researches show that the compound has excellent in-vitro anti-cancer biological activity when the imidazolium structure unit is 5,6-dimethyl benzimidazole and the substituent group thereof on the site of 3 is 2-bromobenzyl, naphthoyl methyl or 4-bromophenacyl.

The invention relates to a preparation method of a polybenzimidazole-structure-similar two-dimensional covalent organic framework, belonging to the technical field of the preparation of covalent organic frameworks. The invention aims at providing the preparation method of the two-dimensional covalent organic framework which is taken as a novel phosphoric acid PBI system. The preparation method comprises the steps of adding 2,5-diamino-3,4-dimethylbenzimidazole and trialdehyde triphenol into an ampoule bottle in a molar ratio of 3 to 2, adding a solvent and a catalyst into the ampoule bottle, carrying out liquid nitrogen freezing degassing-unfreezing-freezing degassing for three cycles, sealing a pipe by virtue of a flame gun, putting the ampoule bottle into a 120-DEG C drying oven, reacting for 3-5 days, opening the pipe, filtering and collecting solid products in the pipe, carrying out Soxhlet extraction on the solid product through tetrahydrofuran, and carrying out vacuum drying at the room temperature, so as to obtain the polybenzimidazole-structure-similar two-dimensional covalent organic framework. The two-dimensional covalent organic framework prepared by virtue of the preparation method has a good microcellular structure.

The invention belongs to the technical field of biological fermentation, and discloses a method for producing vitamin B12 by using Pseudomonas aeruginosa based on pH value control. The method for producing the vitamin B12 by using the Pseudomonas aeruginosa based on the pH value control comprises the steps that a production strain of vitamin B12, namely the Pseudomonas aeruginosa is inoculated into a fermentation medium, and fermentation is carried out at a temperature of 25-30 DEG C; the composition of the fermentation medium comprises 70-85g/L of cane molasses, 90-110g/L of yeast extract, 0.05-0.2 g/L of 5,6-dimethylbenzimidazole, 0.1-1g/L of glycerophosphoric acid, 0.05-2g/L of cobalt chloride, 0.05-0.2g/L of urea, 10-30g/L of betaine, 0.05-0.2 g/L of arginine, 0.01-0.5g/L of thiamine and the like; the pH value of fermentation broth is controlled at 7 by the cane molasses and the urea; and the purified vitamin B12 is separated from the fermentation broth. The yield of the vitamin B12 is improved by controlling the pH in the fermentation process.

The invention discloses a series of N-alkyl substituted indole-imidazolium salt compounds having a structural formula (represented b figure I), and a preparation method thereof. The preparation method comprises the following steps: synthesizing N-alkyl substituted indole from indole used as a raw material and dibromoalkane in an anhydrous DMF solvent, carrying out a heating reaction on the N-alkyl substituted indole and 5,6-dimethylbenzimidazole in a toluene solvent to synthesize N-alkyl substituted indole-imidazole, and carrying out a refluxing reaction on the N-alkyl substituted indole-imidazole and bromoalkane in the toluene solvent to synthesize the N-alkyl substituted indole-imidazolium salt compounds. The compounds have good anti-tumor cytotoxicity activity.

The invention discloses a preparation method and application of biphenyl bridged bis-benzimidazolium. 1,3-dimethyl benzimidazolium iodate and 1,4-diiodobiphenyl as substrates, a metal salt as a catalyst and an alkali as an additive are subjected to reaction at 0-200 DEG C for 0.1-96 hours to obtain biphenyl bridged bis-benzimidazolium via one step. The compound biphenyl bridged bis-benzimidazoliumis dissolved in acetonitrile; a little quality of the obtained solution is injected between two ITO (indium tin oxide) glass sheets; a voltage is applied; the solution turns from no color to coffee;the voltage is removed, and the solution turns colorless; the color variation process is irreversible many times. The preparation method has the advantages that, for instance, the process is simple, operation is convenient, the cost is low, and the preparation method is environmentally friendly and good in repeatability; it is expected to achieve industrial large-scale production. The imidazoliumderivative with electrochromic property is synthesized herein and is expectedly applicable to the fields, such as electronic displays, variable color glass, and automotive anti-dazzling rearview mirrors.

The invention discloses a 11, 12-dimethyl benzimidazole-1, 8-naphthalimide-platinum complex and a preparation method and application thereof. The preparation method of the complex mainly comprises: putting compounds shown in the formulas (II) and (III) into an organic solvent, and performing a coordination reaction process under heating or no heating to obtain a desired product. Compared with thecommon antitumor drug cisplatin, the complex has higher inhibitory activity to some cancer cells and lower toxicity to human liver normal cells HL-7702. The structure of the complex is shown in the formula (I). The raw materials for preparation of the complex are shown in the formulas (II) and (III).

A composition can include a Rho zeolite with a RHO topology having a Si to B ratio or a Si to A1 ratio greater than or equal to 8. Making such a composition can include heating an aqueous reaction mixture having a molar ratio of atomic Si to atomic B of about 4 to about 50 or a molar ratio of atomic Si to atomic Al of about 4 to about 50 in the presence of a C₄-C₆ diquat of N,2-dimethylbenzimidazole structure directing agent to a temperature of at least 75° C. to produce a Rho zeolite.

The invention discloses a preparation method of 5, 6-dimethyl benzimidazole. The preparation method comprises the following four steps: preparation of N-(3, 4-dimethyl phenyl) formamide, preparation of N-(4, 5-dimethyl-2-nitrophenyl) formamide, preparation of N-(2-amino-4, 5-dimethyl phenyl) formamide, and preparation of 5, 6-dimethyl benzimidazole. The preparation method has the following beneficial effects: 1, acetylation and deacetylation used in the prior art are avoided, which is in favor of environmental protection; 2, the synthesis steps of the process are shortened, the original five-step reaction is shortened to the present four-step reaction, and the yield is improved; and 3, the purity of the intermediate is high, separation is not needed, the operation is simple, the defects and deficiencies of the preparation method reported in the literature are overcome, and the method has novelty, greater positive progress effect and practical application value.

The invention discloses a metal complex catalyst and a synthesis process of diphenyl carbonate. The metal complex catalyst comprises a main active component and a carrier, wherein the main active component is loaded on the carrier; the main active component comprises a copper complex and/or a cobalt complex; the copper complex is CuL < 2 > X < 2 >, and the cobalt complex is Co < L > 'X < 2 >; wherein L is N, N-dimethyl benzimidazole (NN-DBDMID), L' is diimine diphosphine (PNNP), and X in the copper complex and X in the cobalt complex are respectively and independently negative ions. The metal complex catalyst disclosed by the invention has the advantages of high catalytic activity, high diphenyl carbonate selectivity, low cost, difficulty in corrosion of a reactor and the like; a process for catalytically synthesizing diphenyl carbonate by using the metal complex catalyst has the advantages of high product yield, simple process, cheap and easily available raw materials, no pollution, safety and capability of greatly reducing the explosion risk.

The invention discloses a series of isosorbide-monoimidazole salt compounds with a structural formula (as shown in a figure I or figure II) and a preparation method of the isosorbide-monoimidazole salt compounds. The preparation method includes: adopting isosorbide as a raw material, performing reaction with methylsulfonyl chloride under an anhydrous pyridine condition to obtain isosorbide methanesulfonate, subjecting to thermal reaction with 2-methylimidazole or 5,6-dimethyl benzimidazole in an anhydrous DMF (dimethyl formamide) solvent to synthesize isosorbide-monoimidazole, and performing reflux reaction with alkyl bromide in a methylbenzene solvent to synthesize the isosorbide-monoimidazole salt compounds. The isosorbide-monoimidazole salt compounds show great analgesic effects.