179results about How to "To achieve the purpose of sustained release" patented technology

The invention relates to a preparation method of salt-tolerance controlled-release high-water-absorption resin with hydrophobic chain segments. At present, acrylic-acid-series high-water-absorption resin has many defects and particularly has the defects that the salt tolerance is poor and the water absorbing capacity is easy to be weakened remarkably and normally is weakened to dozens of times from hundreds of times under the action of metal ions, therefore, the improvement of the salt tolerance of the high-water-absorption resin has significance. According to the invention, the high-water-absorption resin with a three-dimensional cross-linked network is formed through copolymerization of acrylic-acid hydrophobic monomers such as butyl methacrylate, iso-octyl methacrylate, n-decyl methacrylate, lauryl methacrylate, lauryl methacrylate or octadecyl methacrylate with acrylic acid, acrylic amide and carboxymethy cellulose under the existence of initiator and cross-linking agent. Compared with the high-water-absorption resin without the hydrophobic chain segments, the high-water-absorption resin disclosed by the invention has the advantages that the magnification on absorption of 0.9% sodium chloride solution is improved by 89.28%, and the water retention is improved by 13.15%.

The invention provides a multi-drug controllable-loading and long-acting slow-released biomedical coating material and a preparation method thereof. A preparation process comprises the following steps: polishing, washing and drying a substrate material, soaking in dopamine solution (a negative charge layer), and using a catechol-modified multi-amino biomacromolecule (with a positive charge), electronegative macromolecular solution (with a negative charge), and micelle (with a negative charge) loading multiple drugs as three components of layer-by-layer self-assembly, and preparing a coating modified material on a dopamine-processed substrate by using the above three components through a layer-by-layer self-assembly method. Multiple assembling layers can be repeatedly coated, and multiple drug molecules are largely and orderly fixed on a self-assembling coating, so that controllable long-acting release of a drug is realized.

The invention discloses a slow release urea, which comprises the following effective components in parts by weight: 85-98.8 parts of urea, 1-14% parts of bentonite, 0.01-0.5 part of polyacrylamide and 0.01-0.5 part of sodium salt or solution of the sodium salt on the basis of the sodium content. The invention provides a new thought for lowering the urea releasing rate, the slow release action on the urea is different from coated urea and stable urea, the slow release action of the slow release urea is through the diffusion process of moisture in a urea crystal, and water-proof layers are formed layer by layer from outside to inside along with moisture osmosis so as to achieve the slow release purpose.

The invention provides a microcapsule containing dimethyl phthalate, mosquito repellent water and a preparation method thereof. The microcapsule disclosed by the invention comprises dimethyl phthalate, chitosan and gamma-polyglutamic acid. The dimethyl phthalate is coated by utilizing chitosan and polyglutamic acid and is separated from skin, so that irritation to skin is reduced, slow release of the mosquito repellent is realized, and then a mosquito repellent effect is lasting. The mosquito repellent water disclosed by the invention comprises the following main components: the microcapsule containing dimethyl phthalate, aloe extract, hyaluronic acid, polyethylene glycol, propylene glycol, rose hydrosol, water and the like, has the effects of moisturizing, resisting bacteria, diminishing inflammation, relieving itching and the like and is safe and non-toxic. The microcapsule is simple in preparation process, and the wall material has renewability and biodegradability and is non-irritating to skin. According to the mosquito repellent water disclosed by the invention, the dimethyl phthalate is separated from the skin by utilizing the microcapsule, so that bad reactions are reduced; and moreover, a slow release aim of the dimethyl phthalate is achieved, the concentration of the dimethyl phthalate in toning lotion can be reduced, and the effective mosquito repellent time is prolonged.

The invention relates to the agricultural field and the environment-friendly field, in particular to nano microorganism organic and inorganic compound fertilizer and a production method thereof. The fertilizer comprises the following components in parts by weight: 5 to 40 parts of layered silicate, 0.1 to 0.25 part of bacillus megaterium, 0.1 to 0.25 part of bacillus mucilaginosus, 0.1 to 0.25 part of bacillus subtilis, and 0.1 to 0.25 part of base fertilizer containing nitrogen element, potassium element and phosphor element, wherein the nitrogen element, the potassium element and the phosphor element are 6-18% of total weight of the base fertilizer. The production method comprises the following steps: strains of the bacillus megaterium, the bacillus mucilaginosus and the bacillus subtilis are cultivated respectively to obtain strains in a spore state; the base fertilizer is mixed and smashed; and the smashed base fertilizer, the strains in the spore state and the layered silicate are mixed, pelletized and dried. The fertilizer can provide the nutrition needed by crops, and can decompose nitrogen fertilizer, potassium fertilizer and phosphor fertilizer adsorbed and fixed in the soil, so that soil damage is avoided.

The invention provides a water-soluble taxol prodrug using polyethylene glycol as a carrier as well as a preparation method and a chemical modifier thereof. The water-soluble taxol prodrug uses polyethylene glycol as the carrier and malic acid as a connecting arm to prepare a branching-type polyethylene glycol derivative containing a plurality of carboxy groups. The derivative is used for decorating taxol, can greatly improve the taxol carrying capability of the polyethylene glycol, and obviously improves the dissolubility of the taxol so that the solubility of the decorated taxol is from 0.1mg / ml to 6.0mg / ml, and the taxol content in the prodrug is from 1 percent to 38 percent. The invention is beneficial to the improvement of medicament performance.