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42 results about "A-type proanthocyanidin" patented technology

A type proanthocyanidins are a specific type of proanthocyanidins, which are a class of flavanoid. Proanthocyanidins fall under a wide range of names in the nutritional and scientific vernacular, including oligomeric proanthocyanidins, flavanoids, polyphenols, condensed tannins, and OPCs. Proanthocyanidins were first popularized by French scientist Jacques Masquelier.

Method for preparing proanthocyanidins liposomes

The invention discloses a method for preparing proanthocyanidins liposomes, and relates to a method for preparing liposomes. The method solves the problems of large grain size and difficult absorption of a human body by protecting proanthocyanidins in a microcapsule form in the prior art. The method comprises the following steps of: 1, putting soya bean lecithin and cholesterol in a pear-shape flask, adding mixed solution of diethyl ether and absolute ethyl alcohol, adding proanthocyanidins and phosphate buffer, and mixing to obtain mixed solution; 2, performing ultrasonic processing on the mixed solution in a 25 DEG C water bath, performing rotary evaporation to form a film in a water bath at the temperature of between 30 and 50 DEG C and under the pressure of between 400 and 700MPa, adding phosphate buffer again, and performing hydration to obtain coarse suspension; and 3, and filtering the coarse suspension by using a filter membrane of 0.45 mu m. The liposomes are adopted for encapsulating the proanthocyanidins, so the proanthocyanidins are more stable, have small grain size and target, and are favorable for absorption of the human body; the encapsulation rate of the proanthocyanidins liposomes is 88.89 percent; and the preparation process is simple.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Proanthocyanidin effervescent tablet and preparation method thereof

The invention relates to a proanthocyanidin effervescent tablet and a method for preparing the same. The effervescent tablet consists of the following components in the following weight percentage: 2 to 15 percent of proanthocyanidin, 1 to 10 percent of vitamin C, 10 to 40 percent of beta-cyclodextrin, 20 to 50 percent of citric acid, 30 to 35 percent of sodium bicarbonate, 0.5 to 1 percent of protein sugar, 0.1 to 2 percent of flavoring essence, and 0.05 to 0.1 percent of magnesium stearate. The proanthocyanidin effervescent tablet has the advantages that the proanthocyanidin effervescent tablet can be conveniently carried around, used and absorbed as the common effervescent tablets, and simultaneously has characteristics of high concentration of functional substances and strong functionality, as well as bright color of the proanthocyanidin; the proanthocyanidin effervescent tablet has the greatest advantage that the stability of the proanthocyanidin is greatly improved after the proanthocyanidin is embedded by the beta-cyclodextrin; the vitamin C is added in the effervescent tablet to further prevent the proanthocyanidin from being oxidized and act synergistic effect on the antioxidant activity of the proanthocyanidin so as to improve the functionality thereof; furthermore, the proanthocyanidin effervescent tablet has simple formulation, easy preparation, and low cost.
Owner:JIANGSU UNIV

Proanthocyanidin sustained release nano-micro spheres, as well as preparation method and application thereof

The invention relates to proanthocyanidin sustained release nano-micro spheres. The proanthocyanidin sustained release nano-micro spheres comprise 1-5 parts of proanthocyanidin, 1-12 parts of chitosan or derivatives thereof, 1-12 parts of phospholipid or derivatives thereof and 1-10 parts of excipients, wherein the chitosan and the derivatives thereof are one or more of high, medium and low-molecular weight chitosan, chitosan oligosaccharide, chitosan quaternary ammonium salt and carboxymethyl chitosan. The particle size of the proanthocyanidin sustained release nano-micro spheres is 10nm-0.3 mu m; the proanthocyanidin is prepared into the powder sustained release nano-micro spheres, and the proanthocyanidin sustained release nano-micro spheres can directly play a role in the lung as a pulmonary inhalation medicine-carrying formulation, improve the bioavailability of the proanthocyanidin and reduce the dosage by sustained release; the proanthocyanidin nano-micro spheres can also be applied as an oral sustained release formulation; the proanthocyanidin nano-micro spheres have appropriate particle size and morphology and other powder properties, as well as sustained release; furthermore, the preparation method has the advantages of simplicity and convenience in operation, stable process and easiness in industrial production.
Owner:WEIFANG MEDICAL UNIV

Procyanidine effervescent tablet and preparation method thereof

The invention relates to a procyanidine effervescent tablet and a preparation method thereof. The preparation method comprises the following steps: using a Hua Niu apple procyanidine extract as a main raw material; adding a disintegrating agent, an excipient, a flavoring agent and food color, wherein the additives all meet the food sanitation and safety requirements; adopting a direct powder tabletting technology to form the procyanidine effervescent tablet with the certain shape. Procyanidine is a main polyphenol compound combined from different amounts of catechin or epicatechin, and research shows that the procyanidine has the pharmacological functions of protecting heart, improving study and memory functions of mice with study and memory impairments, resisting oxidation, preventing and treating cancer, adjusting blood fat, promoting hair growth and the like. According to the research, the extraction process of procyanidine in apple peel residue is optimized, procyanidine is developed into the procyanidine effervescent tablet, and not only can full utilization of resource be realized, but also a novel health food is additionally provided, so that the health condition of people and the life quality are improved.
Owner:INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI

Analysis method for metabolin of A-type proanthocyanidins

The invention discloses an analysis method for metabolin of A-type proanthocyanidins, which comprises the steps of collection of a biological sample, preparation of metabolin solution, detection of the metabolin and the like, wherein the preparation of the mtabolin solution comprises preparation of hydrolysate, preparation of crude extraction of the metabolin and purification of the metabolin crude extraction. The analysis method for the metabolin of the A-type proanthocyanidins is good in separating purification effect, efficient, fast, high in result accuracy and good in reproducibility, and not only facilitates understanding of a metabolic mechanism and the metabolin, but also plays an important role in further utilization of the A-type proanthocyanidins.
Owner:HUAZHONG AGRI UNIV

Application of proanthocyanidin to preparation of functional food or medicine for improving sperm quality of obese men

The invention discloses application of proanthocyanidin to preparation of a functional food or medicine for improving the sperm quality of obese men and also discloses application of a pharmaceuticalcomposition taking the proanthocyanidin as an active component, and a pharmaceutically acceptable additive to preparation of the functional food or medicine for improving the sperm quality of the obese men. A research proves that the proanthocyanidin has an obvious reduction effect on a weight gain rate of rats fed by high fat diet, and has the effects of improving the level of serum testosterone,protecting the structural integrity of testicles, improving the spermatogenesis obstruction caused by obesity, reducing excessive apoptosis of spermatogenesis cells of the testicles, improving the quantity and vitality of sperms and reducing the distortion rate of the sperms, so that the provided pharmaceutical can be used for improving the sperm quality of the obese men and protecting a reproductive function of the obese men. The invention digs novel medical application of the proanthocyanidin and provides meaningful reference for solving the reproductive dysfunction of the obese men.
Owner:XINXIANG MEDICAL UNIV

Proanthocyanidin oligosaccharide power for endocrine regulation and preparation method of powder

The invention provides a proanthocyanidin oligosaccharide powder for endocrine regulation and a preparation method of the powder. The powder comprises the following components in parts by weight: 3-6parts of plant extracts with proanthocyanidins of greater than or equal to 95%, 70-90 parts of inulin, 10-20 parts of MCT powder, 1-2 parts of coffee powder, 0.5-1.5 parts of tea extracts with tea polyphenols of greater than or equal to 95%, and 0.5-1.5 parts of water-soluble pearl powder. According to the present invention, proanthocyanidins are combined with inulin, MCT powder, coffee powder, tea polyphenols and water-soluble pearl powder to obtain the proanthocyanidin oligosaccharide powder for endocrine regulation, and the powder not only has a good synergistic effect of regulating digestion and absorption, and increases the absorption utilization rate, but also is conducive to the antioxidant ability of proanthocyanidins, tea polyphenols, etc, in the body, improves the ability of removing free radicals in the body, has a more significant conditioning effect, is convenient for taking, and is effectively used in the powder health care products for treating facial skin diseases caused by pigmented dermatosis and skin glandular secretion disorders.
Owner:HAINAN DABAI KANGJIAN PHARMA CO LTD

Procyanidine and traditional Chinese medicine extract composition and application thereof

The invention belongs to the field of healthcare product processing, and provides a pharmaceutical composition. The pharmaceutical composition comprises, by weight, 2.5-5% of procyanidine and 95-97.5%of traditional Chinese medicine extract. A method for preparing the pharmaceutical composition includes sequentially progressively increasingly adding the procyanidine with the low weight into the traditional Chinese medicine extract by the aid of an equal progressive increase process; sufficiently grinding the procyanidine and the traditional Chinese medicine extract until the procyanidine and the traditional Chinese medicine extract are uniform; sieving the procyanidine and the traditional Chinese medicine extract to obtain the pharmaceutical composition. The pharmaceutical composition hasthe advantages that beneficial effects of resisting oxidation and scavenging free radicals can be realized by the procyanidine, effects of benefiting qi, removing blood stasis, regulating menstruation, removing freckle and nourishing skin can be realized by traditional Chinese medicine compositions, and accordingly good auxiliary prevention and treatment effects for preventing and treating skin damage due to the free radicals, promoting blood circulation and enhancing skin cell development can be realized by the pharmaceutical composition; tablets, capsules, granules, oral liquid or wine can be prepared from the pharmaceutical composition according to conventional processes, and the pharmaceutical composition can be applied to preparing healthcare products or additives in cosmetics.
Owner:JIANGSU QIANYAOTANG GUOYI RES INST CO LTD

Proanthocyanidin sustained release nano-micro spheres, as well as preparation method and application thereof

The invention relates to proanthocyanidin sustained release nano-micro spheres. The proanthocyanidin sustained release nano-micro spheres comprise 1-5 parts of proanthocyanidin, 1-12 parts of chitosan or derivatives thereof, 1-12 parts of phospholipid or derivatives thereof and 1-10 parts of excipients, wherein the chitosan and the derivatives thereof are one or more of high, medium and low-molecular weight chitosan, chitosan oligosaccharide, chitosan quaternary ammonium salt and carboxymethyl chitosan. The particle size of the proanthocyanidin sustained release nano-micro spheres is 10nm-0.3 mu m; the proanthocyanidin is prepared into the powder sustained release nano-micro spheres, and the proanthocyanidin sustained release nano-micro spheres can directly play a role in the lung as a pulmonary inhalation medicine-carrying formulation, improve the bioavailability of the proanthocyanidin and reduce the dosage by sustained release; the proanthocyanidin nano-micro spheres can also be applied as an oral sustained release formulation; the proanthocyanidin nano-micro spheres have appropriate particle size and morphology and other powder properties, as well as sustained release; furthermore, the preparation method has the advantages of simplicity and convenience in operation, stable process and easiness in industrial production.
Owner:WEIFANG MEDICAL UNIV

A kind of preparation method of proanthocyanidin

ActiveCN105566274BHigh purityThe degree of polymerization is close toOrganic chemistryAqueous acetonePressure reduction
The invention provides a preparation method of procyanidine. The preparation method includes the following steps: cleaning fresh humulus lupulus prior to airing for standby use; washing the aired humulus lupulus with organic solvent for three times, filtering with filtrate for standby application, and drying filter residue for standby application; crushing the dried filter residue to obtain coarse humulus lupulus powder; extracting the coarse humulus lupulus powder with acetone water solution for three times, and performing low-temperature pressure reduction to remove acetone so as to obtain humulus lupulus procyanidine coarse extract water solution; subjecting the humulus lupulus procyanidine coarse extract water solution to vacuum freeze drying, and washing with n-hexane and dichloromethane for two times respectively to obtain humulus lupulus procyanidine crude extract; subjecting the humulus lupulus procyanidine crude extract to mass spectrometry-mass spectrometry chromatography to obtain humulus lupulus polysaccharide, humulus lupulus anthocyanin low co-polymer and humulus lupulus anthocyanin high polymer. The preparation method of the procyanidine has the advantages that the low polymer and the high polymer of humulus lupulus anthocyanin can be obtained at the same time based on mass spectrometry-mass spectrometry chromatography, and the anthocyanin is high in purity and approximate in degree of polymerization.
Owner:WEIHAI RENSHENG PHARMA GRP
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