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Procyanidins nano milk-like liquid medicine and its preparation

A proanthocyanidin and nanoemulsion technology, which is applied in the field of medicine, can solve the problems of grape seed procyanidin storage instability and easy decrease in activity, and achieve the effects of improving bioavailability, improving drug dispersion, and promoting absorption

Inactive Publication Date: 2007-03-14
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Grape seed proanthocyanidin extract is easy to degrade in the human stomach, grape seed proanthocyanidin is also unstable when stored at room temperature, and its activity is easy to decrease

Method used

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  • Procyanidins nano milk-like liquid medicine and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Preparation method

[0040] Accurately weigh 4.5g of castor oil polyoxyethylene ether-35 (EL-35), 0.5g of isopropyl myristate (IPM), and 0.5g of proanthocyanidin, put them into a beaker, and stir them manually at room temperature of 25°C. Mix well, then slowly add deionized water to it, and stir manually while adding water. At the beginning, the system viscosity is small. As the amount of distilled water increases, the system will become viscous. Continue to add drops and keep stirring. When the system suddenly becomes thinner When, what obtain this moment is dark red transparent oil-in-water proanthocyanidin nanoemulsion drug oral liquid, claims that its gross weight is 25.00g.

Embodiment 2

[0041] Example 2 Preparation method

[0042] Accurately weigh 4g of castor oil polyoxyethylene ether-40 (EL-40), 0.75g of isopropyl myristate (IPM), 0.25g of liquid paraffin, and 0.125g of proanthocyanidin, put them into a beaker, and place them in a beaker at room temperature of 25°C. Mix it well by manual stirring, then slowly add deionized water to it, and manually stir while adding water. When the system suddenly becomes thinner, what is obtained at this time is a dark red transparent oil-in-water proanthocyanidin nanoemulsion drug oral liquid, and water is continuously added to make the final total weight 25.00g.

Embodiment 3

[0043] Example 3 Preparation method

[0044] Accurately weigh castor oil polyoxyethylene ether-40 (EL-40) 7.2g, Span-80 (Span-80) 1.8g, isopropyl myristate (IPM) 1g, proanthocyanidin 0.5g, put into a beaker, At room temperature of 25°C, stir it manually to mix it well, then slowly add deionized water to it, and stir manually while adding water. At the beginning, the viscosity of the system is small. Add dropwise and keep stirring. When the system suddenly becomes thinner, the dark red transparent oil-in-water proanthocyanidin nanoemulsion drug oral liquid is obtained at this time. Continue to add water so that the final total weight is 25.00g.

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Abstract

The invention discloses a procyanidin nanoemulsion drugs the composition of which is procyanidin, non-ionic surfactant, oil, deionized water, its preparation method is surfactant is loaded and weighed according to the proportion formula, choosing oil phase, and make sure that the HLB for its emulsion is close to the HLB of surfactant, then well prepared surfactants and oil phase is mixed according to the original proportion formula, adding proportional anthocyanin, blending and stirring completely, slowly dropwising deionized water and stirring at room temperature until it has similar viscosity with water and become clear transparent solution which is procyanidin nanoemulsion drug. Nano-procyanidin significantly improves the solubility, dispersion of procyanidins in water and its bioavailability, improves the stability of procyanidins. The nano-emulsion can be widely used in cosmetics, pharmaceuticals, beverages, health care products, fodder and other fields.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of proanthocyanidin medicine, in particular to a proanthocyanidin nanoemulsion medicine and a preparation method thereof. Background technique [0002] Proanthocyanidin (PC) is a general term for a large class of flavan-3-ol derivatives that widely exist in plants. It is one of the most powerful natural antioxidants that humans have discovered from nature so far. Antioxidant and free radical scavenging activity. Modern pharmacological studies have shown that proanthocyanidins have a series of excellent biopharmacological effects such as cell protection, anti-mutation, anti-inflammation, anti-allergy, anti-ulcer, improving vision, improving microcirculation, protecting cardiovascular, anti-aging, and anti-tumor. After years of extensive clinical, toxicology, and pharmacokinetic studies, proanthocyanidins have proved that they are non-toxic, non-carcinogenic, non-teratogenic...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/352A61P39/06
Inventor 欧阳五庆安红丽申进宝王俊
Owner NORTHWEST A & F UNIV
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