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Method for preparing hollow fiber with temperature sensitive medicinal hydrogel and application thereof

A technology of temperature-sensitive hydrogel and temperature-sensitive gel, which is applied in the manufacture of hollow filaments, pharmaceutical formulations, fiber chemical characteristics, etc., to achieve the effect of maintaining blood drug concentration, stabilizing blood drug concentration, and alleviating pain and fear

Active Publication Date: 2007-05-16
LANGSHA KNITTING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This drug release system has not been reported at home and abroad, and it has important practical value for the effective and controllable release of drugs.

Method used

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  • Method for preparing hollow fiber with temperature sensitive medicinal hydrogel and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A drug temperature-sensitive hydrogel hollow fiber, with the hollow fiber 1 as a carrier, wherein, the inner cavity of the hollow fiber 1 contains a drug temperature-sensitive hydrogel 2, which is a kind of temperature-sensitive hydrogel that will A phase transition occurs and the drug is released from the hydrogel.

[0033] A method for preparing a drug thermosensitive hydrogel hollow fiber, wherein the drug thermosensitive hydrogel 2 is synthesized in the cavity inside the hollow fiber 1, including the following process:

[0034] The specific process is as follows:

[0035] (1) Preparation and treatment of hollow fibers: polyacrylonitrile hollow fibers were spun, and soaked in pure water for 24 hours after pore-preserving treatment to ensure that the surface of the membrane pores was completely infiltrated by water.

[0036] (2) Insertion of temperature-sensitive monomer solution: prepare 300ml of N-isopropylacrylamide (NIPA) solution with a concentration of 1mol / L, ...

Embodiment 2

[0042] A drug temperature-sensitive hydrogel hollow fiber, with the hollow fiber 1 as a carrier, wherein, the inner cavity of the hollow fiber 1 contains a drug temperature-sensitive hydrogel 2, which is a kind of temperature-sensitive hydrogel that will A phase transition occurs and the drug is released from the hydrogel.

[0043] The preparation method of the drug thermosensitive hydrogel hollow fiber, the drug thermosensitive hydrogel 2 is synthesized in the cavity inside the hollow fiber 1, including the following process:

[0044] (1) Preparation of hollow fibers: Spin cellulose acetate hollow fibers, soak them in pure water for 24 hours after pore-preserving treatment, to ensure that the surface of membrane pores is completely infiltrated by water.

[0045] (2) Insertion of temperature-sensitive monomer solution: same as in Example 1.

[0046] (3) Synthesis of thermosensitive hydrogel: Same as Example 1.

[0047] (4) Preparation of the drug hydrogel: the extract contai...

Embodiment 3

[0051] A drug temperature-sensitive hydrogel hollow fiber, with the hollow fiber 1 as a carrier, wherein, the inner cavity of the hollow fiber 1 contains a drug temperature-sensitive hydrogel 2, which is a kind of temperature-sensitive hydrogel that will A phase transition occurs and the drug is released from the hydrogel. The preparation method of the drug thermosensitive hydrogel hollow fiber, the drug thermosensitive hydrogel 2 is synthesized in the cavity inside the hollow fiber 1, including the following process:

[0052] (1) Preparation of hollow fiber: polyester hollow fiber is spun, soaked in pure water for 24 hours after pore-preserving treatment, to ensure that the membrane pore surface is completely infiltrated by water.

[0053] (2) Insertion of temperature-sensitive monomer solution: same as in Example 1.

[0054] (3) Synthesis of thermosensitive hydrogel: Same as Example 1.

[0055] (4) Preparation of drug hydrogel: mifepristone was used as drug. By volume rat...

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Abstract

The invention relates to a method for preparing temperature-sensitive aquagel hollow fiber, wherein it uses hollow fiber as carrier, whose chamber contains temperature-sensitive aquagel; the aquagel will change phase at human temperature to release the drug. And the preparation comprises a, holding the holes of hollow fiber; b, putting temperature-sensitive monomer solution into the chamber of hollow fiber; c, compositing temperature-sensitive aquagel in the chamber; d, using said aquagel to absorb drub. The invention has better temperature-sensitive property and slow-release property.

Description

technical field [0001] The invention relates to a preparation method and application of a thermosensitive drug carrier hollow fiber, in particular to a drug temperature-sensitive hydrogel hollow fiber capable of realizing drug temperature-sensitive release, and a preparation method and application thereof. Background technique [0002] The treatment of various acute and chronic diseases can be realized through the release of drugs. At present, various release systems such as tablets, injections, suppositories, ointments, and aerosols have been formed. However, due to various reasons, using these common drug administration methods, the drug concentration in the human body can only be maintained for a short period of time and fluctuates greatly; Inconvenient, often difficult to be accepted by patients. Therefore, the traditional drug release system cannot fully meet the needs of patients, and new controllable drug release systems have received more and more attention. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K47/38A61K36/00D01D5/24A61K47/14
Inventor 朱利民朱思君
Owner LANGSHA KNITTING
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