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Control releasing venlafaxine hydrochloride tablet and its prepn

A technology of venlafaxine hydrochloride and controlled-release tablets, which is used in pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of patients with large side effects, fluctuations in blood drug concentration, and poor compliance.

Active Publication Date: 2006-05-17
CHENGDU KANGHONG PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although sustained-release preparations have solved the problem of frequent dosing of the above-mentioned common preparations (only need to take medicine once a day), they can also reduce gastrointestinal side effects to a certain extent; The release and absorption rate of the drug is also affected by factors such as gastric juice or intestinal juice in the patient's body, which is difficult to control and predict, so its blood drug concentration may still fluctuate greatly, with certain instability, and its effective duration and gastrointestinal tract The magnitude of side effects also varies from person to person, and individual differences have a greater impact and are uncontrollable
Patients also often have poor compliance due to frequent medication or severe side effects

Method used

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  • Control releasing venlafaxine hydrochloride tablet and its prepn
  • Control releasing venlafaxine hydrochloride tablet and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The venlafaxine hydrochloride controlled-release tablet preparation with a weight ratio of drug tablet core and semipermeable film coating of 1:0.035, wherein:

[0052] The composition of the drug tablet core is: 75 parts of venlafaxine hydrochloride, 114 parts of microcrystalline cellulose, 4 parts of sodium chloride, 6 parts of povidone K30 and 1 part of magnesium stearate.

[0053] The composition of the semipermeable film coating was: 9 parts of cellulose acetate, 0.78 parts of diethyl phthalate and 0.22 parts of polyethylene glycol 1500.

[0054] The preparation method of above-mentioned venlafaxine hydrochloride controlled-release tablet preparation, comprises the following steps:

[0055] (1) Preparation of drug tablet core: get the venlafaxine hydrochloride, microcrystalline cellulose, sodium chloride and povidone K30 of the proportioning, mix well, add 95% ethanol solution to make soft material in right amount, pass 20 Mesh sieve granulation, drying at 50°C, g...

Embodiment 2

[0060] The venlafaxine hydrochloride controlled-release tablet preparation with a weight ratio of drug tablet core and semipermeable film coating of 1:0.05, wherein:

[0061] The composition of the drug tablet core is: 75 parts of venlafaxine hydrochloride, 120 parts of microcrystalline cellulose, 1 part of sodium chloride, 15 parts of povidone K30 and 0.1 part of magnesium stearate.

[0062] The composition of the semipermeable film coating was: 6 parts of cellulose acetate, 0.9 part of diethyl phthalate and 0.1 part of polyethylene glycol 1500.

[0063] The preparation method of above-mentioned venlafaxine hydrochloride controlled-release tablet preparation, comprises the following steps:

[0064] (1) Preparation of drug tablet core: get the venlafaxine hydrochloride, microcrystalline cellulose, sodium chloride and povidone K30 of the proportioning, mix well, add 90% ethanol solution to make soft material in right amount, pass 20 Mesh sieve granulation, drying at 40°C, gran...

Embodiment 3

[0069] A venlafaxine hydrochloride controlled-release tablet preparation in which the weight ratio of the drug tablet core to the semipermeable film coating is 1:0.02, wherein:

[0070] The composition of the drug tablet core is: 75 parts of venlafaxine hydrochloride, 100 parts of microcrystalline cellulose, 30 parts of sodium chloride, 1 part of povidone K30 and 10 parts of magnesium stearate.

[0071] The composition of the semipermeable film coating was: 12 parts of cellulose acetate, 0.6 part of diethyl phthalate and 0.4 part of polyethylene glycol 1500.

[0072] The preparation method of above-mentioned venlafaxine hydrochloride controlled-release tablet preparation, comprises the following steps:

[0073] (1) Preparation of drug tablet core: get the venlafaxine hydrochloride, microcrystalline cellulose, sodium chloride and povidone K30 of the proportioning, mix well, add 95% ethanol solution to make soft material in right amount, pass 20 Mesh sieve granulation, drying a...

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Abstract

The present invention discloses one kind of control releasing venlafaxine hydrochloride tablet and its preparation process. The control releasing venlafaxine hydrochloride tablet consists of medicine core of venlafaxine hydrochloride and semi-permeable coating with pores. The medicine core consists of venlafaxine hydrochloride 75 weight portions, stuffing 30-250 weight portions, osmotic pressure promoter 1-50 weight portions, adhesive 1-20 weight portions and lubricant 0.1-20 weight portions. The preparation has reasonable composition, excellent control releasing effect, long effective time, less side effect on gastrointestinal tract, less differential personal effect, high safety and good compliance.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a controlled-release tablet preparation of a novel antidepressant venlafaxine hydrochloride, and to a preparation method of the controlled-release tablet preparation. Background technique [0002] Venlafaxine is a new type of antidepressant, which has the remarkable characteristics of quick effect (4 days to 1 week), good tolerance, and good short-term and long-term therapeutic effects. At present, the venlafaxine preparations that have been marketed or reported at home and abroad include ordinary preparations and sustained-release preparations of different specifications, such as ordinary capsules, sustained-release tablets, sustained-release capsules and sustained-release pellets. However, venlafaxine in common preparations has problems such as short half-life (about 5±2 hours), frequent administration (2-3 times a day), and relatively large side effects. Although su...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K9/20A61P25/24
Inventor 潘卫三李威
Owner CHENGDU KANGHONG PHARMA GRP
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