5308 results about "Microcrystalline cellulose" patented technology

The invention relates to viable and stable probiotic formulations for intestinal targeting made of microspheres comprising each a core of one or more probiotic bacteria, microcrystallline cellulose with a degree of polymerization from 165-365 and mean diameter from 45 to 180 μm, a disintegrant and a stabilizer, the core being coated with a non-enteric coating and further coated with an enteric coating. Each probiotic microsphere has a residual moisture level of less than 5% and a water activity (aw) between 0.1 and 0.5. Such a probiotic microsphere shows no reduction in viable bacteria after one hour in simulated gastric fluid. The present invention also relates to the process of preparing such formulation.

A pharmaceutical preparation for the treatment of attention deficit disorders combines a therapeutically effective amount of digestive enzymes, such as chymotrypsin, and medication used to treat attention deficit disorders, such as Ritalin®, Concert®, Adderall® and Strattera®. The preparation may be in the form of a tablet, capsule or time released formula in order to reduce the amount of pills per dosage. The pharmaceutical preparation ameliorates the symptoms of the attention deficit disorder. The preparation has a stabilizing matrix containing a solidified microcrystalline cellulose which captures and protects therapeutically effective amounts of digestive enzyme particles within the stabilizing matrix.

The present invention is directed to coprocessed excipient particles comprising a cellulosic material such as microcrystalline cellulose in intimate association with silicon dioxide, a disintegrant and a polyol, sugar or a polyol / sugar blend. The excipient particles display good processing and are useful in prepared compressed solid dosage forms that exhibit rapid disintegration (less than about 60 seconds) when placed on the tongue or when tested according to USP disintegration testing, while still providing acceptable mouth feel.

A composition, comprising (a) microcrystalline cellulose; and (b) a compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; or (ii) inhibits interactions between adjacent cellulose surfaces; or (iii) accomplishes both (i) and (ii) above, is disclosed. The composition is in the form of agglomerated particles of microcrystalline cellulose and the compressibility augmenting agent in intimate association with each other.

Direct compressed solid pharmaceutical dosage forms containing:a) from about 40 to about 95% by weight acetaminophen;b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; andc) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e., up to 80% or greater) amounts of acetaminophen based on the weight of the total tablet.

The present invention relates to the production of texturized microcrystalline cellulose from raw pulp material. This texturized microcrystalline cellulose can then be used for surface treatment of paper or paper board. Additionally, the texturized microcrystalline cellulose may be used as a starting material for production of paper or paper board.

Ultra-fine microcrystalline cellulose compositions are disclosed which comprise co-attrited microcrystalline cellulose and a hydrocolloid. The compositions have a mean particle size of less thin 10 microns. The compositions are prepared by subjecting a high solids mixture of microcrystalline cellulose and a hydrocolloid to high shear forces in the presence of an anti slip agent preferably an aqueoussolution of an inorganic salt. The compositions are especially useful in food pharmaceutical and cosmetic and industrial applications.

A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.

The invention discloses a medicinal preparation rizatriptan benzoate capsule for treating migraine and a preparation method thereof. Every 10000 capsules are prepared from the following formulation constituents: 29-250g of rizatriptan benzoate, 20-400g of microcrystalline cellulose, 220-1100g of starch, 100-400ml of 10-20% polyvinyl pyrrolidone ethanol solution and 4-30g of magnesium stearate. The invention also provides a preparation method of the rizatriptan benzoate capsule. The capsule of the invention covers the foreign taste of the main medicine; release and absorption of the medicine are accelerated; medical particles in the capsule are not punched or molten, thereby overcoming some defects of tablets; after the capsule is taken orally, the medicine is directly dispersed in the gastrointestinal fluid and is moistened by the gastrointestinal fluid, thus the effective surface area is large; and the medicine has higher dissolving rate in the gastrointestinal fluid, can be better absorbed and has high bioavailability.

Pharmaceutical compositions useful for treating autoimmune diseases in a mammal comprising as an active ingredient a therapeutically effective amount of Copolymer 1, and microcrystalline cellulose are disclosed. Processes for the manufacture of such compositions are also disclosed.

A cigarette having a multi-component filter wherein an upstream sorbent removes at least one constituent from mainstream tobacco smoke passing through the filter and a downstream flavor segment compensates for taste lost to the sorbent. The flavor component includes cellulosic flavor bearing granules which release volatile flavor constituents into the mainstream smoke under ambient conditions. The cellulosic granules include microcrystalline cellulose or other cellulosic material which can be formed into a paste with the flavor additive, extruded and spheronized to form the flavor granules.

A nicotine-containing particulate material for release of nicotine, the material comprising a combination of nicotine or a pharmaceutically acceptable salt, complex or solvate thereof and a microcrystalline cellulose. The particulate material is stable upon storage and releases nicotine relatively fast. The particulate material can be used in the manufacture of nicotine containing pharmaceutical composition, wherein the release of nicotine can be designed to be relatively fast so as to obtain a fast onset of action.

The present invention relates to the production of texturized microcrystalline cellulose from raw pulp material. This texturized microcrystalline cellulose can then be used for surface treatment of paper or paper board. Additionally, the texturized microcrystalline cellulose may be used as a starting material for production of paper or paper board.

The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.

The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.

Direct compressed solid pharmaceutical dosage forms containing:a) from about 40 to about 95% by weight acetaminophen;b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; andc) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricantare disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e., up to 80% or greater) amounts of acetaminophen based on the weight of the total tablet.

The invention provides a preparation method of a polylactic acid / nano cellulose composite material. The composite material comprises the following components in percentage by weight: 55 to 99.8% of polylactic acid, 0.1 to 15% of nano cellulose, and 0.1 to 30% of polyethylene glycol. The method comprises the following steps of: preparing a 5 to 15% an aqueous solution of microcrystalline cellulose, dripping concentrated sulfuric acid until the concentration of sulfuric acid reaches 40 to 60%, stirring and reacting for 1 to 2hours, carrying out centrifugation, ultrasound treatment and adjusting pH value to be neutral to obtain a nano cellulose suspension; dissolving polyethylene glycol, mixing with the nano cellulose suspension, stirring for 1 to 3hours at the temperature of 90 DEG C and carrying out vacuum drying to obtain a polyethylene glycol / nano cellulose comixture; and carrying out melt blending on the polyethylene glycol / nano cellulose comixture and polylactic acid for 5 to 8minutes at the temperature of 120 to 170 DEG C to obtain the composite material. The method is convenient and simple to operate, short in the time of the preparation process and solves the problem of uniform dispersion of nano-cellulose in the polylactic acid.

The present invention relates to the production of texturized microcrystalline cellulose from raw pulp material. This texturized microcrystalline cellulose can then be used for surface treatment of paper or paper board. Additionally, the texturized microcrystalline cellulose may be used as a starting material for production of paper or paper board.

The invention relates to stomach-nourishing spleen-strengthening chewing tablets and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The chewing tablets comprises the raw materials of, by weight: 6-9 parts of Mongolian milkvetch root, 5-8 parts of pilose asiabell root, 3-5 parts of ligusticum, 7-11 parts of common yam rhizome, 6-8 parts of dried longan, 8-12 parts of medlar, 7-9 parts of red date, 3-7 parts of dried tangerine peel, 8-12 parts of hawthorn fruit, 10-12 parts of stir-fried malt, 60-80 parts of microcrystalline cellulose, 10-20 parts of micro-powder silica gel, 2-10 parts of a hydroxymethyl cellulose, and 1-3 parts of a flavoring agent. The chewing tablets are prepared through three steps which are extraction, granulation, and tableting. The process provided by the invention is simple. The prepared chewing tablets have the advantages of rich nutrients, good taste, convenient application, and long effect. The tablets have the functions of stomach nourishing, spleen strengthening, qi invigorating, and digestion promoting.

Pharmaceutical compositions containing ezetimibe or its pharmaceutically acceptable salt that is substantially free of microcrystalline cellulose or crystalline cellulose are disclosed. Also disclosed are pharmaceutical compositions containing micronized particles of ezetimibe.

An aqueous-based sprayable composition comprises a therapeutic or palliative agent, water and a mixture of microcrystalline cellulose and alkali metal carboxyalkylcellulose. In one embodiment, the composition is a non-Newtonian nasal spray exhibiting a very rapid viscosity recovery upon removal of shear forces.

The invention provides an emulsion stabilizer for a vegetable protein beverage, the vegetable protein beverage as well as a preparation method thereof. The emulsion stabilizer for the vegetable protein beverage comprises 20-40wt% of glycerin monostearate, 10-30wt% of sucrose fatty acid ester, 5-10wt% of sodium stearyl lactate, 10-25wt% of xanthan gum, 10-20wt% of microcrystalline cellulose, 5-10wt% of konjac glucomannan and 5-10wt% of sodium hexametaphosphate. The invention further discloses the preparation method of the emulsion stabilizer for the vegetable protein beverage as well as use thereof in the vegetable protein beverage. Meanwhile, the invention further provides the vegetable protein beverage and the preparation method thereof. The emulsion stabilizer for the vegetable protein beverage provided by the invention can effectively prevent the vegetable protein beverage from unhealthy phenomena such as fat floating, precipitation, flocculation, layering and the like, thereby guaranteeing that the product is uniform and stable in expiration date.

The invention relates to a method for preparing an NCC / CS / PVA composite nanofiber membrane. NCC is rod-shaped particles, wherein the diameter of each particle ranges from 20 nm to 60 nm, and the particles are highly crystallized. The method comprises the steps that (1) an NCC / CS solution is prepared, wherein the concentration of the NCC, by weight, ranges from 0.09% to 0.21%; (2) an NCC / PVA solution is prepared, wherein the concentration of the NCC, by weight, ranges from 0.4% to 0.8%; (3) an acetic acid solution, tetraethyl orthosilicate, the NCC / CS solution obtained in the step (1) and processed through ultrasound, and the NCC / PVA solution obtained in the step (2) and processed through ultrasound are mixed to obtain a spinning solution, and the nanofiber membrane is obtained through the electrospinning technology, wherein the mass ratio of the acetic acid solution to the tetraethyl orthosilicate to the NCC / CS solution to the NCC / PVA solution is (2.5-3.5):(1.5-2.5):5:5; (4) the obtained nanofiber membrane is immersed in an alkaline solution for 2-6 hours at the normal temperature, and the membrane structure can be stable. The method for preparing the NCC / CS / PVA composite nanofiber membrane has the advantages that the nanofiber material preparation process is simple, the preparation process is environmentally friendly and free of pollution, nanofibers are excellent in mechanical performance, the surface of the nanofiber membrane is rich in modifiable functional groups, and the nanofiber membrane has a remarkable affinity effect on biomacromolecule.

The invention relates to superfine microcrystalline cellulose with particle size less than 10mum. The superfine microcrystalline cellulose with the particle size less than 10mum is obtained by degradation and superfine treatment of microcrystalline cellulose. The superfine microcrystalline cellulose can be widely applied to preparation of food additives, pharmaceutic adjuvants, emulsion stabilizers of cosmetics and thickening stabilizers of coating, and has high dispersibility and storage stability in water, better forming property, adhesiveness, water swellable property, thickening property, thixotropy and the like.

The nanometer microcrystal cellulose powder is surface modified nanometer microcrystal cellulose with added hydrophilic colloid in the amount of 5-150 wt% of nanometer microcrystal cellulose and has grain size of 6.3-100 nanometers. During its preparation, hydrophilic colloid is dispersed homogeneously into water dispersed medium of surface modified nanometer microcrystal cellulose and the mixture is then dried and crushed. The nanometer microcrystal cellulose is easy to be water dispersed to form colloid, which is homogeneous and high in gluing strength and has the small size of microcrystal cellulose maintained, so that it has wide and unique application foreground in food production, medicine, papermaking, textile, new material preparation and other fields.

The invention discloses a preparation method for a nanocrystals cellulose / white carbon black / rubber composite material. The nanocrystals cellulose (Nanocrystals Cellulose, called NCC for short) is a rod-shaped crystallized product which is obtained by performing acidolysis on microcrystalline cellulose, has the diameter of between 20 and 60 nm and the average length of 300 nm, can serve as a novel reinforcing material for rubber, and has the characteristics of reproducibility, low density, orientation, high strength and the like; moreover, the preparation method is simple and convenient; the cost is low; and the NCC is easy to obtain. Researches discover that a reinforcing effect of the NCC to natural rubber is superior to that of white carbon black; the thermal-oxidative ageing property of the natural rubber is improved very well; simultaneously the heat generation of the composite material is reduced; and the nanocrystals cellulose / white carbon black / a rubber composite material can be prepared by adopting a conventional rubber processing process. The nanocrystals cellulose / white carbon black / a rubber composite material prepared by the invention can be used for manufacturing various vulcanized rubber products.

The invention discloses a microcapsule for self-repair concrete and a preparation method of the self-repair concrete. The microcapsule comprises a capsule core and a capsule wall, wherein the capsule core is composed of a repair agent, microcrystalline cellulose and Tween 80; and the capsule wall material is a crack-stress-sensitive high-polymer organic material. The preparation method of the self-repair concrete comprises the following steps: weighing proper amounts of cement, sand, water and the microcapsule, wherein every cubic meter of concrete contains 0.05-0.08 cubic meter of microcapsule; stirring the cement, sand and microcapsule until the components are dispersed uniformly; and pouring the water into the mixture of the cement, sand and microcapsule, and stirring uniformly. The microcapsule can be doped into the concrete to form the microcapsule concrete self-repair system, thereby implementing self-repair capability of the concrete crack; and the microcapsule concrete self-repair system has the characteristic of intelligent control.

The invention relates to a biology adsorbent and a preparation method thereof as well as application of the preparation method in heavy metal ion adsorption. The biology adsorbent is characterized in that hybrid blending material which has heavy metal ion adsorption capability is prepared by the capability of biological polymer such as microcrystalline cellulose, chitin, chitosan, etc. which can be dissolved in ionic liquid; the ionic liquid is chloridized 1-butyl-3-methyl imidazole salt and chloridized 1-allyl-3-methyl imidazole salt; the preparation of the adsorbent adopts two types: a drying type and a freeze-drying type; the ionic liquid used in the method can be recovered; the prepared adsorbent can be automatically degraded in environment; the preparation method and the prepared adsorbent in the method cause no secondary environmental pollution.

The invention discloses a preparation method for highly effective compound dietary cellulose. The method of the invention is characterized in that: the highly effective compound dietary cellulose is prepared with the following materials, insoluble dietary fiber, water-soluble dietary fiber, vitamin C and lactic acid bacteria powder, in definite proportions. The product of the invention is the highly effective compound dietary cellulose which is provided with dual characteristics of insoluble dietary fiber and water-soluble dietary fiber and the dosage form of the product can be capsules or granules. The long-term taking of the product of the invention can ensure obvious curative effects on high blood pressure, high blood fat, high cholesterol, diabetes, obesity, constipation, gastro-intestinal diseases, etc. If being added with different materials such as microcrystalline celluloses, magnesium stearate, maltodextrin, citric acid, sodium bicarbonate and PEG6000, according to different preparation forms, the product can also be prepared into tablets, chewable tablets and effervescent tablets. The highly effective compound dietary cellulose of the invention has simple, scientific and reasonable prescription, simple technology and stable quality, and is easy to be produced in large scale, thus being a safe and green health-care food product.

Formulations containing a PDE5 inhibitor, a water-soluble diluent, a lubricant, a hydrophilic binder, a disintegrant, and optional microcrystalline cellulose and / or a wetting agent, and their use in treating sexual dysfunction, are disclosed.