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Preparation method of flunixin meglumine injection liquid

A technology of flunixin meglumine and injection, which is applied in the field of preparation of flunixin meglumine injection, can solve problems such as crystallization and stratification, and achieve the effect of simple method, easy operation and reduced precipitation

Inactive Publication Date: 2017-10-10
遂宁市中通实业集团动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing flunixin meglumine injection is prone to crystallization and stratification due to the solubility of flunixin meglumine itself

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, a preparation method of flunixin meglumine injection comprises the following steps:

[0018] a. Prepare materials: select 8.4 parts of flunixin meglumine, 15 parts of PEG-400, 0.2 part of anhydrous sodium sulfite, 0.02 part of edetate disodium, and 100 parts of water for injection by weight;

[0019] b. Dissolving: get 60 parts of water for injection by weight, add flunixin meglumine of prescribed quantity, stir to make it dissolve completely to obtain liquid A; stir anhydrous sodium sulfite and edetate disodium with appropriate amount of water for injection Dissolve liquid B; add liquid B to liquid A, then add the prescribed amount of PEG-400, add water for injection to the full amount, add 0.1% of the total volume of medicinal activated carbon, stir evenly; decarbonize through a titanium rod filter until clear ;

[0020] c. Inspection: Sampling and testing, the pH value of the solution is controlled at 8.2-8.9, and the content of intermediates is contro...

Embodiment 2

[0022] Embodiment 2, a kind of preparation method of flunixin meglumine injection comprises the following steps: a. Raw material preparation: select 8.6 parts of flunixin meglumine, 16 parts of PEG-400, 0.25 parts of anhydrous sodium sulfite, Edetate disodium 0.025 parts, water for injection 100 parts for standby;

[0023] b. Dissolving: get 65 parts of water for injection by weight, add flunixin meglumine of prescribed quantity, stir to make it dissolve completely to obtain liquid A; stir anhydrous sodium sulfite and edetate disodium with appropriate amount of water for injection Dissolve B liquid; add B liquid to A liquid, then add the prescribed amount of PEG-400, add water for injection to the full amount, add 0.12% of the total volume of medicinal activated carbon, stir well; decarbonize through a titanium rod filter until clear ;

[0024] c. Inspection: Sampling and testing, the pH value of the solution is controlled at 8.2-8.9, and the content of intermediates is contr...

Embodiment 3

[0026] Embodiment 3, a kind of preparation method of flunixin meglumine injection comprises the following steps: a. Raw material preparation: select 8.2 parts of flunixin meglumine, 14 parts of PEG-400, 0.15 parts of anhydrous sodium sulfite, Edetate disodium 0.015 parts, water for injection 100 parts for standby;

[0027] b. Dissolving: get 55 parts of water for injection by weight, add flunixin meglumine of prescribed quantity, stir to make it dissolve completely to obtain liquid A; stir anhydrous sodium sulfite and edetate disodium with appropriate amount of water for injection Dissolve B liquid; add B liquid to A liquid, then add the prescribed amount of PEG-400, add water for injection to the full amount, add 0.8% of the total volume of medicinal activated carbon, stir evenly; decarbonize through a titanium rod filter until clear ;

[0028] c. Inspection: Sampling and testing, the pH value of the solution is controlled at 8.2-8.9, and the content of intermediates is cont...

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Abstract

The invention belongs to the field of veterinary drugs, and particularly relates to a preparation method of flunixin meglumine injection liquid. The flunixin meglumine injection liquid comprises, by weight, 8.4 parts of flunixin meglumine, 15 parts of PEG (polyethylene glycol)-400, 0.2 part of anhydrous sodium sulfite, 0.02 part of edetate disodium and 100 parts of water for injection. According to the method, firstly, dissolving the flunixin meglumine by the aid of part of water to obtain solution A, and dissolving the anhydrous sodium sulfite and the edetate disodium by the aid of part of water to obtain solution B; secondly, adding the solution B into the solution A, adding the PEG-400, adding the balance water again, and uniformly mixing mixture; finally, absorbing suspended solid particles by the aid of drug active carbon, and removing carbon to obtain the flunixin meglumine injection liquid. The method is simple and easy to operate, and the possibility of sedimentation of the injection liquid is effectively reduced.

Description

technical field [0001] The field of veterinary medicine of the present invention, especially a kind of preparation method of flunixin meglumine injection. Background technique [0002] Flunixin meglumine is a veterinary anti-inflammatory analgesic. Flunixin meglumine has antipyretic, anti-inflammatory and analgesic effects. It can significantly improve clinical symptoms and enhance the activity of antibiotics when used alone or in combination with antibiotics. In veterinary medicine, it is often used to relieve horses' visceral colic, pain caused by muscle and bone disorders, and anti-inflammation; to control acute inflammation caused by various diseases and infections in cattle, such as laminitis, arthritis, etc., and can also be used for females. Adjuvant treatment of porcine mastitis, metritis and agalactia syndrome. [0003] Flunixin meglumine can be taken orally and injected, but due to absorption reasons, it is generally used by injection. The existing flunixin megl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/44A61K47/18A61P29/00
CPCA61K9/08A61K9/0019A61K31/44A61K47/183
Inventor 郑伯均
Owner 遂宁市中通实业集团动物药业有限公司
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