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570results about How to "Reduce recurrence" patented technology

HERCEPTIN adjuvant therapy

ActiveUS20060275305A1Decrease subject ' likelihood of cancer recurrenceIncrease subject ' likelihood of survivalBiocideOrganic active ingredientsAdjuvantAdjuvant therapy
Owner:GENENTECH INC

Product delivery system

A sensor device for detecting product quality conditions is attached to each product to be delivered, and constant monitoring is performed on quality conditions of stock products in a storage room of a delivery center for quality assurance. For products in a storage room of a delivery truck, constant monitoring is also performed on quality conditions thereof in the same manner. If a quality abnormality is found in a product in the storage room, information regarding product sensing items and information regarding the current location of each delivery truck are processed to select a replacement stock product less susceptible to recurrence of a similar quality abnormality at the time of redelivery.
Owner:HITACHI LTD

Polypeptide, nucleic acid for coding polypeptide, polypeptide-modified T lymphocyte and application of T lymphocyte

The invention belongs to the technical field of biology, and discloses a polypeptide containing two chimeric antigen receptor structures, nucleic acid for coding the polypeptide, a modified T lymphocyte, and a preparation method and application of the T lymphocyte. The polypeptide provided by the invention contains the two chimeric antigen receptor (CAR) structures, wherein one chimeric antigen receptor structure specifically targets a tumor cell, and the other one specifically targets a normal B lymphocyte, so that a CAR-T cell is effectively amplified through recognizing the B lymphocyte ofa blood circulation system, and more CAR-T cells arrive at a solid tumor part so as to specifically kill the tumor cell for improving a treatment effect on the solid tumor. The polypeptide further comprises an ScFv structure of an anti-PD-L1 monoclonal antibody, and the CAR-T cells can simultaneously secrete a PD-L1 monoclonal antibody which interdicts an immunosuppressive action medicated by a PD1/PDL1 signal pathway and T cell failure, so that the treatment effect on the solid tumor is improved, the functional activity of immune cells in vivo is prolonged at the same time, and finally the tumor recurrence is retarded and even avoided.
Owner:HEBEI SENLANG BIOTECH CO LTD

Manufacturing method for individualized lip and tongue side orthodontic appliance

The invention provides a manufacturing method for an individualized lip and tongue side orthodontic appliance. According to the manufacturing method, the individualized lip and tongue side orthodontic appliance is manufactured according to a lip and tongue side shape of teeth of a patient; a manufactured bracket is divided into two parts; one part is a bracket body of the bracket; the other part of the bracket is an individualized bracket bottom plate of the bracket. The bracket body of the bracket in the orthodontic appliance contains three-dimensional data (whole tooth axis inclined degree, whole tooth torque and whole tooth convexity) of countryman normal whole teeth (dental crowns and tooth roots) reference values. Meanwhile, the designed bracket bottom plate is completely fitted with a lip and tongue side face of the teeth and the bonding strength of the bottom plate and the lip and tongue side face is enhanced. According to the manufacturing method, the whole teeth can be moved to one accurate position to realize the controllable quantitative movement of the whole position of the teeth; the tooth roots are placed on an ideal position; the requirements of special crowd are met and the reoccurrence after the correction is reduced; the occurrence rate of complications including bone exposure, bone fracture and the like is avoided, and the balance and the stability of the orthodontic effect is realized.
Owner:史建陆 +1

Ablation of Myocardial Tissues with Nanosecond Pulsed Electric Fields

An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
Owner:OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Gynura procumbens compound preparation as well as preparation method and application thereof

The invention belongs to the field of health beverages, and in particular relates to a gynura procumbens compound preparation as well as a preparation method and application thereof. The gynura procumbens compound preparation is characterized by being prepared from the following raw materials in percentage by weight: 75-85% of gynura procumbens, 5-10% of barley seedlings, 3-6% of common lophatherum herb, 2-5% of frostbitten mulberry leaves, 2-4% of kudzuvine root and 1-3% of poria cocos. The preparation method of the gynura procumbens compound preparation comprises the following steps: performing weighing, drying and small fire baking on gynura procumbens, then mixing with other weighed raw materials, and crushing. The preparation disclosed by the invention is safe, healthy and natural, has various effects of treating gout in multiple ways comprehensively, can play roles in adjusting uric acid metabolism, promoting excretion of uric acid, preventing uric acid crystallization, diminishing inflammation and relieving pain, and controlling arthralgia, swelling and inflammations in an attack stage of gout, also can be used for reducing the blood lipid and blood sugar and strengthening kidney metabolism, can be used for treating both symptoms and root causes and achieving the effects of preventing and treating gout, and has the characteristics of natural compounds and natural health maintenance; and the preparation method disclosed by the invention is simple and convenient, and can be used for keeping original components of the raw materials to the greatest extent.
Owner:袁丁
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