The invention belongs to the field of health beverages, and in particular relates to a gynura procumbens compound preparation as well as a preparation method and application thereof. The gynura procumbens compound preparation is characterized by being prepared from the following raw materials in percentage by weight: 75-85% of gynura procumbens, 5-10% of barley seedlings, 3-6% of common lophatherum herb, 2-5% of frostbitten mulberry leaves, 2-4% of kudzuvine root and 1-3% of poria cocos. The preparation method of the gynura procumbens compound preparation comprises the following steps: performing weighing, drying and small fire baking on gynura procumbens, then mixing with other weighed raw materials, and crushing. The preparation disclosed by the invention is safe, healthy and natural, has various effects of treating gout in multiple ways comprehensively, can play roles in adjusting uric acid metabolism, promoting excretion of uric acid, preventing uric acid crystallization, diminishing inflammation and relieving pain, and controlling arthralgia, swelling and inflammations in an attack stage of gout, also can be used for reducing the blood lipid and blood sugar and strengthening kidney metabolism, can be used for treating both symptoms and root causes and achieving the effects of preventing and treating gout, and has the characteristics of natural compounds and natural health maintenance; and the preparation method disclosed by the invention is simple and convenient, and can be used for keeping original components of the raw materials to the greatest extent.