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Flunixin meglumine coated granule and preparation method thereof

A technology of flunixin meglumine and coated granules, which is applied in the field of flunixin meglumine coated granules and its preparation, which can solve the problems of irritating the respiratory tract and eyes, poor compliance, and discomfort of workers, and achieve stress Reduced, increased feed intake, good curative effect

Inactive Publication Date: 2015-01-07
ZHENGZHOU FUYUAN ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, no matter whether flunixin meglumine is a raw material or a solid preparation (granules, tablets, etc.), those who have been in contact with it know that it has a strong pungent taste, which can irritate people's respiratory tract and eyes, cause cough, runny nose, etc. Very uncomfortable symptoms such as tears and runny nose
Ordinary granulation methods, the entire production process will cause discomfort to workers who are directly exposed to the drug. Even if fluidized bed granulation is used, since no coating is performed, subsequent packaging, use by farmers, and animal feed intake will be difficult. Poor compliance, which ultimately leads to a reduction in animal feed intake and affects the efficacy of the curative effect
[0008] Chinese patent document "a tablet containing flunixin meglumine and its preparation method" (application publication number: CN103222968A) discloses a tablet containing flunixin meglumine and its preparation method. Fluidized bed granulation and then tableting, but without coating, the pungent smell emitted by flunixin meglumine will cause abnormalities in the operating object and the user object, whether it is operated by workers, used by farmers, or eaten by animals unwell

Method used

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  • Flunixin meglumine coated granule and preparation method thereof
  • Flunixin meglumine coated granule and preparation method thereof
  • Flunixin meglumine coated granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Formation

[0033]

[0034] Preparation Process

[0035] 1) Weighing: Weigh the prescribed amount of anhydrous glucose and vanillin into a one-step granulator for fluidized mixing:

[0036] 2) Prepare the drug solution as an adhesive: add the prescribed amount of flunixin meglumine into 21 g of water, and heat to dissolve if necessary;

[0037] 3) Granulation: spray the drug solution into the fluidized material for granulation;

[0038] 4) Coating: first prepare a coating solution, add 5 g of coating powder to 20 g of water, stir and dissolve, and set aside. After the granules are formed, they are dried and then sprayed into the coating solution.

[0039] 5) After the coating is completed, it is dried and ready to be obtained.

Embodiment 2

[0041] Formation

[0042]

[0043] Preparation Process

[0044] Same as Example 1, except that the prescription quantities of raw materials, anhydrous glucose and coating powder are different.

Embodiment 3

[0046] Party:

[0047]

[0048] Preparation Process:

[0049] Same as Example 1, except that the prescription quantities of raw materials, anhydrous glucose, vanillin and coating powder are different.

[0050] The flunixin meglumine coated granule of embodiment 1 carries out the accelerated test in the stability test

[0051] Stability test method: Prepare 3 batches of products (20130806, 20130807, 20130808) according to Example 1, place them under the condition of temperature 40 ℃ ± 2 ℃ and relative humidity 75% ± 5% for 6 months according to the commercially available packaging, and test During the 1st, 2nd, 3rd, and 6th months, samples were taken once respectively, and the properties, dissolution rate, and content of the key stability inspection items were tested. The results of the stability test are shown in Table 1.

[0052] Table 1 Stability test results of flunixin meglumine granules

[0053]

[0054] The clinical trial situation of the flunixin meglumine coa...

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Abstract

The invention relates to a flunixin meglumine coated granule and a preparation method thereof. The preparation method of the flunixin meglumine coated granule comprises the following steps: dissolving raw materials in a solvent (serving as an adhesive), spraying into auxiliary materials which are uniformly mixed in a fluidized bed to carry out granulation, and finally spraying into a water-soluble coating solution to prepare the flunixin meglumine coated granule. The flunixin meglumine has very strong pungent smell which causes abnormal discomfort to the respiratory tracts and eyes of people in the production, packaging and using processes; according to the flunixin meglumine coated granule, the flunixin meglumine is dissolved in the solvent, sprayed into the auxiliary materials of the fluidized bed and finally coated, so that the operators and farmers are prevented from the pungent smell in the whole production, packaging and using processes; and above all, the coated granule is capable of reducing the sensitivity of the animals and improving the compliance, so that the effect of the coated granule can come into play better.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to flunixin meglumine-coated granules and a preparation method thereof. Background technique [0002] Flunixin meglumine is an effective non-anesthetic, non-steroidal antipyretic, anti-inflammatory, analgesic, and anti-endotoxin drug. It is currently the only antipyretic, anti-inflammatory, and analgesic drug for animals. The antipyretic, anti-inflammatory and analgesic effect is exact, and the curative effect is good. It has a good therapeutic and relieving effect on the clinical symptoms of inflammation and fever caused by whatever reason, and its efficacy is higher than that of analgesic, meperidine, codeine, phenylbutazone, aspirin, and analgin. Combined use with antibiotics can also enhance the activity of antibiotics, improve curative effect, shorten the course of treatment, and effectively reduce the side effects of antibiotics on animal bodies. In a...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/44A61K47/38A61K47/32
Inventor 王树槐袁宝青李红娇石磊
Owner ZHENGZHOU FUYUAN ANIMAL PHARMA
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