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Long-acting flunixin meglumine injection and method for preparing same

A technology for flunixin meglumine and injection, which is applied in the field of long-acting flunixin meglumine injection and its preparation, can solve the problems of short half-life, fast excretion, unfavorable treatment of animal diseases, etc., and reduce labor intensity , Improve the effect of treatment, reduce the effect of stress response

Active Publication Date: 2009-10-07
SHAOSHAN DABEINONG ANIMAL MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Flunixin meglumine absorbs quickly, but excretes quickly and has a short half-life, requiring multiple administrations to achieve the desired therapeutic effect, which not only consumes a lot of manpower but also causes multiple stresses to sick animals, which is not conducive to The treatment of the disease does not meet the requirements of animal welfare

Method used

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  • Long-acting flunixin meglumine injection and method for preparing same

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Take 40ml of water for injection, add 0.03g of EDTA-2Na, 5g of PVP k30, 25g of poloxamer 407 and 5g of flunixin meglumine in sequence, stir and dissolve; adjust the pH value to 7.0-7.5, and dilute to volume with water for injection To 100ml, filter; potting, cobalt 60 ray sterilization, that is.

Embodiment 2

[0019] Take 40ml of water for injection, add 0.01g of EDTA-2Na, 30g of PVP k17 and 3g of flunixin meglumine in sequence, stir and dissolve; adjust the pH value to 7.0-7.5, dilute to 100ml with water for injection, filter; potting , cobalt 60 ray sterilization, that is.

Embodiment 3

[0021] Take 40ml of water for injection, add 0.02g of EDTA-2Na, 1g of PVP k15, 50g of poloxamer 124 and 5g of flunixin meglumine in sequence, stir and dissolve; adjust the pH to 7.0-7.5, and dilute to volume with water for injection To 100ml, filter; potting, cobalt 60 ray sterilization, that is.

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Abstract

The present invention relates to a long-acting flunixin meglumine injection for animals and method for preparing same. The invention provided flunixin meglumine injection delays medicine absorption so as to prolong medicine action time by adding proper polyvinylpyrrolidone and poloxamer high molecular compound in the preparation process. Approved by clinical experiments that action time of the invention is longer than common flunixin meglumine injection, the invention reduces labor strength and reduces stress response of animals with more obvious medicine effect, and capable of using with long-acting antibacterials to provide a synergistic effect. The invention provides a animals specific medicine of long-acting, effective antipyretic, antiphlogosis and analgesic for veterinary clinical.

Description

technical field [0001] The invention belongs to the technical field of veterinary preparations, and relates to a long-acting flunixin meglumine injection and a preparation method thereof. Background technique [0002] Schering-Plough Corporation of the United States launched a non-steroidal drug for animals - flunixin meglumine (flunixin meglumine) at the end of the last century. It has a unique structure and is a cyclooxygenase inhibitor. The production of prostaglandins can effectively prevent Escherichia coli endotoxin from increasing the bronchial exudate in respiratory diseases, and the accumulation of neutrophils and albumin in the exudate. It is a very effective anti-inflammatory and anti-inflammatory agent. Pain, antiendotoxin and antipyretic NSAIDs. [0003] Because livestock and poultry are attacked by bacteria, viruses, and mycoplasma, most of the clinical symptoms are accompanied by inflammatory symptoms (fever, pain), which affect the normal diet, activities an...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/44A61K47/34A61K47/32A61P29/00A61K47/10
Inventor 田玲杨秀玉周德刚秦玉明莫云刘澜冯华兵葛代兴葛冰王海良文波郭致君庞加春丛日刚
Owner SHAOSHAN DABEINONG ANIMAL MEDICINE
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