187 results about "Sinomenine" patented technology

The invention provides a preparation method of sinomenine, comprising the process for preparing and refining a sinomenine crude product. The preparation method provided by the invention comprises the following steps of: wetting and percolating caulis sinomenii coarse powder with HCL (hydrochloric acid), and extracting and crystallizing the percolation liquid to obtain a sinomenine crude product; and adding ethanol or purified water in the sinomenine crude product and heating and refluxing till the sinomenine crude product is dissolved, adding active carbon for filtering, then cooling, crystallizing, filtering and cleaning a filter cake with ethanol till the filtrate is colorless, and thus obtaining the sinomenine. The preparation method is simple to operate, belongs to cold treatment completely without the need of needs heating in the extraction process; the yield is high, and mother liquid is treated simply; moreover, the preparation method is safe and reliable, causes low pollution and plays a positive effect on environmental protection because only inorganic acid and alkali and a mall amount of level-two toxicity solvent are used.

The invention discloses 14-hydroxyl sinomenine derivatives, a preparation method thereof and anti-inflammatory activity thereof. The 14-hydroxyl sinomenine derivatives are prepared from the raw materials of O-alkyl sinomenine and O-acyl sinomenine by a chemical method that reactions such as oxidation and hydroxylation are carried out at a 14-position. The compounds of the invention show excellent anti-inflammatory activity in in-vivo tests of animals and have an excellent application prospect.

The invention relates to a method for separating and preparing tetrandrine and hanfangchin through ion exchange and column chromatography on silica gel. Fourstamen stephania root is dried root of a menispermaceae stephania plant stephania tetrandra, an effective ingredient of the fourstamen stephania root is sinomenine, main effective ingredients of sinomenine are tetrandrine and hanfangchin, and the sinomenine has anti-myocardial ischemia, anti-arrhythmia, blood pressure lowering, anti-inflammatory, anti-silicosis, anti-cancer and analgesic effects. When in drug use, the purity requirement of the tetrandrine and hanfangchin reaches more than 99%, and extraction and purification are important reasons limiting the drug use of the tetrandrine and hanfangchin. At present, a technology for extracting and purifying the tetrandrine and hanfangchin applies massive toxic and expensive chloroform and strong base, and the chloroform has great toxic effect on human and the environment and is also strong corrosive on equipment for enlarged production; besides, sample purity is not high, and a technological process is complex. At the current situation, the invention develops a method for obtaining high-purity tetrandrine and hanfangchin through rapid separation and purification by applying ion exchange resin and a C18 bonded silica gel column chromatography and also discloses a method for recrystallizing and purifying the tetrandrine and hanfangchin by utilizing ethyl alcohol. The method provided by the invention has the advantages that a preparation technology does not apply any toxic reagent, column chromatography filler can be recycled, and ethyl alcohol can be recycled.

An orally applied slow-releasing micropill of tuduranine or its salt is composed of core and coated layer. Said core is prepared from tuduranine hydrochloride powder and fillers. Said coated layer is prepared from ethyl cellulose.