Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound prescription of Chinese medicinal effective ingredients having anti-neovascularization synergetic effect

A technology of synergy and active ingredients, applied in the directions of medical preparations containing active ingredients, active ingredients of heterocyclic compounds, drug combinations, etc. complex interactions

Active Publication Date: 2007-05-23
TSINGHUA UNIV
View PDF0 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the medicinal ingredients of the "Qingluoyin" compound are complex, and the prescriptions are not a simple superposition of medicinal ingredients, but there are complex interactions between the ingredients
Therefore, the original "Qingluo Decoction" compound in the form of traditional Chinese medicine decoction pieces has many deficiencies and limitations that are common in existing traditional Chinese medicine prescriptions, such as complex ingredients, difficult quality control, unclear material basis for efficacy, and unclear drug action mechanism.
[0005] In general, the current treatment status of anti-angiogenesis-related diseases (rheumatoid arthritis) is: (1) there is still a lack of effective traditional Chinese medicine for the treatment of rheumatoid arthritis.
(2) There are no Chinese patent medicines and Chinese medicine preparations characterized by anti-angiogenesis for the treatment of rheumatoid arthritis
(3) Combinations of traditional Chinese medicines against angiogenesis-related diseases that have not been patented in the form of effective combinations of traditional Chinese medicines
(4) In the face of a huge and growing market for angiogenesis-related diseases such as rheumatoid arthritis, the treatment needs are far from being met

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound prescription of Chinese medicinal effective ingredients having anti-neovascularization synergetic effect
  • Compound prescription of Chinese medicinal effective ingredients having anti-neovascularization synergetic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: The formula for one dose is: the dose of matrine is 2000 μg / ml, the dose of sinomenine is 100 μg / ml, and the ratio of matrine and sinomenine is 1:0.05. This example has the strongest interaction effect on inhibiting endothelial cell proliferation, with an inhibition rate of 80.16%;

Embodiment 2

[0026] Example 2: The formula for one dose is: the dose of matrine is 1350 μg / ml, the dose of sinomenine is 300 μg / ml, and the ratio of matrine and sinomenine is 1:0.22. This example has the interactive effect of inhibiting the proliferation of endothelial cells, and the inhibition rate reaches 72.02%;

Embodiment 3

[0027] Example 3: The formula for one dose is: the dose of matrine is 888 μg / ml, the dose of sinomenine is 394 μg / ml, and the ratio of matrine and sinomenine is 1:0.44. This example has the interactive effect of inhibiting the proliferation of endothelial cells, and the inhibition rate reaches 70.91%;

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
correlation coefficientaaaaaaaaaa
Login to View More

Abstract

The invention relates to a traditional medicine with vessel growth resistance function, wherein it is formed by matrine and kukoline at 1:0.05-1 ratio. It can improve treatment effect and reduce toxicity, on atrophic arthritis, cancer, etc.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical formulations, and in particular relates to a combined formulation of active ingredients of traditional Chinese medicines with anti-angiogenesis synergistic effect. Background technique [0002] "Angiogenesis" (new blood vessel formation) is a common pathological link of major diseases such as rheumatoid arthritis (RA) and tumors that endanger people's lives and health. Anti-angiogenesis drugs are an important way to block the progression of rheumatoid arthritis and "starve tumors" (treatment of solid tumors) and other diseases. Taking rheumatoid arthritis as an example, at present, the rheumatoid drug market in China mainly includes non-steroidal anti-inflammatory drugs, slow-acting drugs and Chinese patent medicines. At present, traditional Chinese medicines dedicated to the treatment of rheumatoid arthritis are mainly Chinese patent medicines, including the following 12 kinds: Fengshi Ha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61P35/00A61K31/4375
CPCA61K31/438A61K31/4375A61K31/55A61P35/00A61K2300/00
Inventor 李梢吴敏
Owner TSINGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com