118results about How to "Ability to inhibit migration" patented technology

There is provided a semiconductor device that suppresses the occurrence of resin burrs and has favorable electrical connectivity and bond strength, and a manufacturing method for such semiconductor device. A resin-coated metal part is manufactured by forming an organic coating by depositing a material including functional organic molecules on a wiring lead composed of a metallic material. Each of the functional organic molecules includes a main chain, a first functional group having a metal bonding property, and a second functional group. The first functional group and the second functional group are provided at different ends of the main chain. Thereafter the functional organic molecules self-assemble by bonding of the first functional groups to metal atoms of the wiring lead. After performing the organic coating formation step, resin is adhered to a predetermined surface area of the wiring lead having the organic coating formed thereon.

The invention discloses (6S)-3-acetyl-4-oxo-4,6,7,12-tetrahydroindole [2,3-a] quinolizine-6-formyl-Arg-Gly-Asp-Ser structured as follows, wherein the standard abbreviation of Arg-Gly-Asp-Ser is RGDS. The invention discloses a preparation method therefor, a nanostructure thereof, antitumor action thereof and action thereof in resisting adhesion, invasion and migration of tumor cells, and illustrates application thereof in medical science. The formula is shown in t he description.

The invention relates to a polypeptide and chemotherapy drug combined drug-loaded micelle and a preparation method and an application thereof. Polypeptide with a tumor targeting therapeutical effect and a chemotherapy drug are combined to prepare the tumor-targeting polypeptide-PEGylated phospholipid complex-chemotherapy drug drug-loaded micelle; the polypeptide with the tumor targeting therapeutical effect is specifically combined with a chemotactic factor receptor CXCR4, the CXCR4 polypeptide antagonist is used for increasing a targeting penetration ability of the drug to tumor tissues, the PEGylated phospholipid micelle is used for increasing the drug biological stability and the drug loading amount, and compared with a single chemotherapy drug doxorubicin, the combined drug-loaded micelle shows a stronger characteristic of inhibiting tumor cell vitality. The polypeptide and chemotherapy drug combined drug-loaded micelle provides a feasible method and technique for improving the tumor therapeutic effect.

The invention provides lung adenocarcinoma exosome specific miRNAs, and a target gene and applications thereof. High flux sequencing technology is combined with systematic bioinformatics analysis methods, the specific high-content exosome miRNAs related with lung adenocarcinoma is obtained through screening; the RNA sequences of the lung adenocarcinoma exosome specific miRNAs are represented by SEQ ID No.1-3. It is found that the common target gene of the miRNAs is FOXN3. The target gene is capable of inhibiting fibroblast migration capability, reduction of the expression amount of the targetgene is capable of promoting entering of fibroblast into tumor tissues, and promoting tumor growth. The lung adenocarcinoma exosome specific miRNAs and the target gene thereof can be taken as lung adenocarcinoma diagnosis markers and can be used for preparation of diagnostic kits. An inhibitor of the miRNAs or an expression promoter of the target gene can be used for preparing medicines used for treating lung adenocarcinoma, or medication guidance in treatment of lung adenocarcinoma; and the clinical application value is relatively high, and the application prospect is promising.

The invention discloses a preparation method of a heat stability-enhanced porous silver-magnesium-aluminum alloy film, and relates to the technical field of photoelectric materials. The preparation method comprises the following steps: firstly preparing a silver-magnesium-aluminum alloy film through a thin film deposition technology, wherein the silver-magnesium-aluminum alloy film is prepared from the following chemical components in percentage by mass: 50 to 60 percent of a magnesium element, 3 to 10 percent of an aluminum element and 30 to 47 percent of a silver element; and then corroding active metals through dealloying reaction liquid, thus forming a nano porous structure which takes silver as a framework and is doped with a little of aluminum and magnesium. After being subjected to high temperature treatment, the porous silver-magnesium-aluminum alloy film prepared through the preparation method still can keep the porous structure, so that a relatively wide absorption spectrum and a relatively good absorption effect can be kept. The preparation process is simple, the repetitiveness is high, and the cost is low; the shortcoming in the heat stability of a porous silver-based film in the prior art can be overcome; and actual popularization and application of the porous silver-based film are facilitated.

The invention discloses a lovastatin silicon plastid of a targeted breast cancer stem cell and a preparation method thereof.The lovastatin silicon plastid is prepared from, by weight, lovastatin 2%-30%, organic-inorganic compound lipid 20%-70%, phosphatidyl ethanolamine-polyethylene glycol 2000 1%-20% and distearoyl phosphatidylcholine 10%-60%.The lovastatin silicon plastid overcomes the shortcoming that the bioavailability of lovastatin drugs in the prior art is low.

The invention discloses 1-(4-isopropyl propyl)-beta-carboline-3-formyl-Trp-Trp-Trp-Lys-Glu structured as follows, a preparation method therefor, a nanostructure thereof, antitumor action thereof, action thereof in resisting adhesion and invasion and migration of tumor cells, and illustrates application thereof in medical science. The formula is shown in the description.

The invention discloses a long chain noncoding RNA marker for auxiliary diagnosis of colorectal cancer (CRC). Long chain noncoding RNA is HOTAIR; auxiliary diagnosis or prediction of patient conditiondevelopment of the CRC can be realized by detecting expression quantity of the long chain noncoding RNA; differentiation, infiltration depth, proliferation and metastasis conditions of the CRC can bepredicted by monitoring expression conditions of p21 and a value of judging prognosis is realized. Expression level of LncRNA HOTAIR gene can be detected by RT-qPCR, real-time quantitative PCR, immunodetection, in-situ hybridization, chip or a high-throughput sequencing platform; meanwhile, the invention also discloses silencing HOTAIR which can obviously inhibit the proliferation, migration andinvasion abilities of CRC cells, reduce the expression of PCNA, Ki67, cyclin E and CDK2 and medicate expression increase of p21. The invention provides a molecular marker for the CRC and provides theoretical basis for mechanism research and clinical individualized therapy of the CRC; a brand-new treatment strategy can be provided for clinically treating the CRC by monitoring the expression of theLncRNA HOTAIR in the CRC.

The invention relates to Trp-Trp-Trp decapeptide modified beta-carboline, discloses a preparation method and the nanometer structure of beta-carboline, relates to the in-vivo and in-vitro antitumor effects of beta-carboline, and relates to effects of beta-carboline to resist tumor cell adhesion invasion and migration. Therefore, the invention discloses application of Trp-Trp-Trp decapeptide modified beta-carboline to prepare antitumor medicines and prepare medicines resisting tumor cell adhesion invasion and migration. The invention belongs to the field of biological medicine.

The invention discloses an application of a polypeptide Kp-10 in preparation of a medicine for treating and preventing osteosarcoma. The amino acid sequence of the polypeptide Kp-10 is DSSDSSDSSDSSDSSDSSYNWNSFGLRF. Researches find that expression of GPR54/KiSS-1 in osteosarcoma tissues is obviously lower than that in normal tissues beside the tumor tissues, and is highly related to clinical prognosis, and the polypeptide Kp-10 and a receptor GPR54 of the polypeptide Kp-10 can inhibit proliferation and migration capacity and lung metastasis capacity of osteosarcoma cells, so that the polypeptide Kp-10 can be used for preparing medicines for treating and preventing osteosarcoma, and a new thought is provided for exploration of osteosarcoma targeted medicine.

The invention belongs to the field of application of traditional Chinese medicine, and particularly relates to application of a Babao pill in preparation of medicines for inhibiting malignant development of stomach cancer. The malignant development of the stomach cancer comprises the recurrence of the stomach cancer and the transfer and diffusion of stomach cancer cells. The Babao pill has good development and application prospect, and the novel application is disclosed for the first time. The Babao pill mainly is prepared from the following components of calculus bovis, snake gall, antelope horn, pearl powder, radix notoginseng and musk.

The invention discloses an application of salvianolic acid A in preparing an anti-tumor metastasis medicine. The invention has the importance of discovering that the salvianolic acid A in salvia miltiorrhiza has notable inhibiting effect on tumor metastasis, has obvious influence on the tumor metastasis related gene and protein, can selectively inhibit proliferation of tumor cells, and has safety and low toxicity to normal cells of the human body, so that the salvianolic acid A has application prospects in preparing the anti-tumor metastasis medicine.

The invention discloses a preparation method and application of an antitumor protein, and belongs to the technical field of biological medicines. According to the invention, a protein shown in SWQ IDNO.1 is screened and verified to be applied to resistance to tumor for the first time; and a CCK8 (Cell counting kit-8) proliferation experiment result shows that a PvEXP100 protein can remarkably inhibit the proliferation of a HepG2 cell, and the inhibition rate is up to 80.1%, so that the migration performance of the HepG2 cell is almost completely inhibited. The PvEXP100 protein involved in theinvention, as an active ingredient or a raw material, can be prepared into an antitumor medicine, and has a wide application prospect.

The invention discloses application of millet bran active polyphenol in preparation of a product for preventing and treating atherosclerosis. Experiments prove that the millet bran active polyphenol can significantly inhibit migration ability of human aortic smooth muscle cells, can significantly inhibit lipid phagocytosis ability of the human aortic smooth muscle cells and human mononuclear macrophages, and can inhibit formation of in-vivo atherosclerotic plaques, thereby preventing and treating atherosclerosis. The millet bran active polyphenol is taken as a main component and can be used for preparing functional foods or medicines for preventing and/or treating atherosclerosis.