Polypeptide and chemotherapy drug combined drug-loaded micelle and preparation method and application thereof
A technology of chemotherapy drugs and drug-loaded micelles, which is applied in the field of medicine and biology, and can solve the problem of low drug loading
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Embodiment 1
[0112] A polypeptide nanomicelle formed by self-assembly of polyethylene glycolated phospholipid (PEG-PE) and E5 polypeptide, wherein the polyethylene glycol hydrophilic block in the polyethylene glycolated phospholipid (PEG-PE) molecule The molecular weight of the polypeptide is 2000, the molar ratio of PEGylated phospholipid (PEG-PE) and E5 polypeptide is 20:1, and the particle size of the polypeptide nanomicelle is 10-30nm.
Embodiment 2
[0114] A polypeptide nanomicelle formed by self-assembly of polyethylene glycolated phospholipid (PEG-PE) and E5 polypeptide, wherein the polyethylene glycol hydrophilic block in the polyethylene glycolated phospholipid (PEG-PE) molecule The molecular weight is 2000, the molar ratio of pegylated phospholipid (PEG-PE) and E5 polypeptide is 10:1, and the particle size of the polypeptide nanomicelle is 10-30nm.
Embodiment 3
[0116] A polypeptide nanomicelle formed by self-assembly of polyethylene glycolated phospholipid (PEG-PE) and E5 polypeptide, wherein the polyethylene glycol hydrophilic block in the polyethylene glycolated phospholipid (PEG-PE) molecule The molecular weight of the polypeptide is 2000, the molar ratio of PEGylated phospholipid (PEG-PE) and E5 polypeptide is 5:1, and the particle size of the polypeptide nanomicelle is 10-30nm.
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