Application of sinomenine or pharmaceutically acceptable salt thereof as medicament for preventing and treating pulmonary interstitial fibrosis
A technology of pulmonary interstitial fibrosis and sinomenine, applied in the field of alkaloids, can solve problems such as organ or tissue damage, achieve the effects of preventing occurrence and development, clarifying the chemical structure, and eliminating adverse effects
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[0116] Experimental example: Effect of sinomenine on bleomycin-induced pulmonary fibrosis in mice and its mechanism
[0117] Pulmonary fibrosis is a common pathological change of various heterogeneous interstitial lung diseases represented by idiopathic pulmonary fibrosis (IPF), and it is the main cause of respiratory failure and death caused by the irreversible development of such diseases. The pathogenesis remains unclear. Traditional corticosteroids and immunosuppressants in the treatment of diffuse pulmonary interstitial fibrosis are not only ineffective but also have many adverse reactions. Currently, there is no effective treatment other than lung transplantation. Sinomenine is an alkaloid monomer extracted from the traditional Chinese medicinal plant S. chinensis. Studies have found that it has anti-inflammatory, anti-oxidation, immunosuppressive, and analgesic effects. It is used in the treatment of rheumatic diseases such as rheumatoid arthritis. widely used in (Zho...
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