159 results about "Heat labile" patented technology

Hardenable and hardened dental compositions, and articles including such hardenable and hardened compositions, are provided. The hardenable dental compositions include a thermally labile component including one or more thermally labile groups. Upon heating, the hardened compositions are useful, for example, for reducing the bond strength of orthodontic appliances adhered to tooth structures with the hardened compositions.

Disclosed herein are heat-labile prodrugs, their preparation and uses.

The invention aims at acid, alkali and heat labile features of sinomenine molecular structure, and provides an innovative structural reconstruction idea for new chemical synthesis of ring A, ring C, and ring D sinomenine derivatives. The chemical synthetic method includes amination and acylation of 1-position, C-C or C-O connection of 1 position, dicarbonylation and six-membered N heterocyclization of 3-position and 4-position, two molecule sinomenine adduction of connection of 4-hydroxyl and 1-amino, amination and acylation of 6-position, simultaneous amination and x-membered N heterocyclization of 6-position and 7-position, and opening of D ring and terminal amino group modification thereof. The method is novel and unique. The sinomenine derivatives have good antiinflammation activity and bioactivity evaluated by synovial membrane tumor cell (SW982), and can be used in drug and health products for resisting rheumatoid arthritis.

The invention relates to a novel IR laser desorption/vacuum UV single-photon ionization mass spectrum analyzing device for analysis and detection of a biological sample, which solves the problems of the prior art that uses matrix and is unlikely to analyze complex mixture with low polarity and low molecular weight. The device is structurally characterized in that a photoionization chamber is arranged on one side of a time-of-flight mass spectrometer, an ion injection hole is provided on one sidewall of the photoionization chamber, an ion injector and a sample target are arranged in the chamber, a laser is disposed outside the photoionization chamber on the sample target side, and vacuum UV light source is arranged on the other side. By combining IR laser desorption technology and vacuum UV ionization mass spectrum technology, the invention can achieve high-efficiency and rapid analysis without selecting different matrixes according to the sample and without complex pre-treatment and separation of the sample, thus preventing the matrix interference on mass spectral signals. The invention is specifically suitable for analysis of thermal-unstable and nonvolatile organic compounds and biological molecules.

Disclosed in certain embodiments is a solid oral dosage form comprising a heat-labile gelling agent; a thermal stabilizer; and a drug susceptible to abuse.

A method of packaging thermally labile goods. The method includes the steps of (a) obtaining a legend correlating thermally labile goods with a PCM panel color, (b) locating the thermally labile goods to be packaged on the legend and identifying the correlated PCM panel color, (c) obtaining thermally conditioned panels of the correlated PCM panel color from amongst a plurality of differently colored thermally conditioned panels color coded in relation to the phase change temperature of the phase change material contained within the panels, (d) lining the retention chamber of a thermally insulated container with the obtained thermally conditioned PCM panels, (e) placing the thermally labile goods to be packaged into the lined retention chamber, and (f) closing the container.

A method of producing a mixture comprises providing, in a container, at least a first component of the mixture at a first temperature; adding a remaining component of the mixture to said at least a first component; subjecting the container to a rotational motion about a first axis in a first direction while rotating the container about a second axis in a second direction to effect a mixing; wherein the first temperature is lower than the temperature of the mixture at the end of the mixing.

The ability to incorporate iodoform, tetracycline and a combination of iodoform/tetracycline into root canal gutta percha points is described. The iodoform, tetracycline and iodoform/tetracycline combination are bound within the gutta percha points. They act as a reservoir of antimicrobial that is capable of diffusing onto the surface of the gutta percha thereby inhibiting the colonization of bacteria on the gutta percha points and within the root canal system. Tetracycline is capable of coalescing within the dentinal tubules to inhibit long term microbial growth. These medicated gutta percha points are site specific, surface acting antimicrobial gutta percha points.A method of the usage and delivery of amorphous form iodoform gutta percha, iodoform/tetracycline gutta percha, or tetracycline gutta percha within a heated compule with a pressure plunger by delivering the thermo-softened heat labile amorphous form via a pressure extrusion system through a cannula into the prepared root canal system.

The present invention is low temperature process of preparing anatse type crystalline titania film, and belongs to the field of wide-gap semiconductor photocatalyzing technology. Titania film is deposited on the substrate through reactive magnetically controlled sputtering, and the deposition process has the base with the substrate cooled by a water cooling system, argon flow rate of 30 sccm, the flow rate between argon and nitrogen of 5-10, total gas pressure of 1-4 Pa, power density of 1.4-2.8 W/sq cm, negative voltage applied on the base of 20V-100, and base temperature always lower than 80 deg.c. During the film depositing process, great amount of positive argon ion is driven by the base bias voltage to bombard the deposited titania film so as to form anatse type crystalline titania film on the heat labile substrate.

The invention relates to a method and a system for continuously preparing 5-hydroxymethylfurfural (5-HMF) and a derivative 5-alkoxymethylfurfural (5-AMF) thereof with hexose or hexose-containing biomass as a material. The method takes the characteristic of thermal instability in a target product into full consideration and utilizes the characteristic of distinct polarity difference between the product and the material, a reaction unit and an extraction unit are separated in the process of preparing the 5-HMF and the 5-AMF, the biomass material reacts along with a polar reaction phase under high temperature and existence of a catalyst, the produced product flows out of reaction environment in time, and after being cooled, the product is extracted and retained by a non-polar extraction phase under normal temperature and pressure. The insufficiently reacting material or a polar intermediate product is retained in the polar reaction phase, and enters the reaction unit again to form circulation until the reaction is sufficient. In order to increase the distribution ratio and extraction efficiency of the product, a certain amount of inorganic salt can be added into a polar solvent. The method and the device effectively increase the selectivity and yield of the target product, and remarkably reduce the energy consumption of the whole preparation process. Material resources applicable to the method and the system are wide, including soluble monosaccharide, insoluble lignocellulose and the like. Pickiness about catalysts is avoided, and homogenous and heterogeneous catalysts which are commonly used in such reaction are all applicable to the method and the system.

Disclosed is a top coating composition formed on a resist film, for protecting the resist film, the top coating composition being a top coating composition for photoresist, characterized by containing a fluorine-containing polymer having a repeating unit represented by the following general formula (1). This composition is capable of controlling developing solution solubility and has a high water repellency.

[In the formula, R¹ represents a hydrogen atom, fluorine atom, methyl group or trifluoromethyl group, R² represents a heat-labile protecting group, R³ represents a fluorine atom or fluorine-containing alkyl group, and W is a bivalent linking group.]

Compound methilanin thiamin is used to assist treat that acute and chronic hepatitis, fatty liver, early cirrhosis of liver, toxic hepatitis brought by arsenic and barbiturate and other diseases in clinic. But, there is only liquid drugs injection supplied in market at present. Compound methilanin thiamin is unstable to heat; thiamin is easy to decompose on condition of solution, opacification or precipitate; after sterilization at high temperature, content of thiamin in liquid drugs injection will decrease for decomposition; meantime the storage and transport for liquid drugs injection is not convenient. The invention overcomes the shortage of methilanin thiamin liquid drugs injection, increases stability of drug, is propitious to transport and storage; and avoids freezing easily in winter and affecting quality of drug, prolongs drug storage life, improves quality of drug, in order to treat patients more safely and effectively.

An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72 of the A subunit is mutated, preferably by substitution with Arg. The toxoid is useful as vaccine against an enterotoxigenic strain of E. coli and is produced by recombinant DNA means by site-directed mutagenesis. It is also an effective adjuvant.

A GC-IMS system is disclosed in embodiments of the present invention. The system comprises a sample transfer device. The sample transfer device connects the gas chromatograph to the reaction region and, the sample from the gas chromatograph is transferred to the reaction region by the sample transfer device directly, instead of not through the ionization region. With the GC-IMS system, generation of sample molecular ion fragments can be avoided so that the spectrum is brevity and is easily identified; moreover, the application field of the GC-IMS system is extended to a range of analysis of organic macromolecule samples which have a high polarity, are difficult to volatilize, and are thermally instable. On the other hand, the GC-IMS system overcomes the defect of ion destruction due to neutralization reaction among positive and negative ions so as to evade the detection.

Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucleic acid replication reactions. In certain aspects, the methods are accomplished by use of 3′-substituted NTPs and/or 3′-substituted terminated primers which provide utility in nucleic acid replication. In preferred embodiments, the NTPs and/or primers are substituted at the 3′-position with particular heat labile chemical groups such as ethers, esters or carbonate esters.

The invention relates to an o-phthalaldehyde disinfectant and a preparation method thereof. The o-phthalaldehyde disinfectant comprises the following components in percentage by weight: 0.2 to 1 percent of o-phthalaldehyde, 0.1 to 0.5 percent of salicylic acid, 0.5 to 1.5 percent of dodecyldimethylbenzylammonium chloride, 1 to 10 percent of ethanol, 0.1 to 1 percent of disodium hydrogen phosphate, 1 to 10 percent of ethanol, 0.1 to 1 percent of sodium dihydrogen phosphate, 0.1 to 0.5 percent of inhibitor, 0.01 to 0.1 percent of ethylene diamine tetraacetic acid and the balance of water. The method for preparing the disinfectant comprises the steps of: adding the o-phthalaldehyde into the ethanol according to the content and component, stirring and mixing the materials; adding water into the materials and stirring the mixture; and adding the dodecyldimethylbenzylammonium chloride, the disodium hydrogen phosphate, the sodium dihydrogen phosphate, the inhibitor and the ethylene diamine tetraacetic acid into the mixture in sequence and stirring the mixed solution to allow the added materials to dissolve to obtain the o-phthalaldehyde disinfectant. The disinfectant has the advantages of no pungent smell, safety, low toxicity, stable property and convenient use, can be used for high-level disinfection of the heat-labile medical equipment and is particularly applicable to an endoscope automatic washing and disinfecting machine to perform high-level disinfection on an endoscope.