136results about How to "Promotes an increase in induction" patented technology

This invention relates to a vaccine and a method for immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, an infectious disease, or a condition associated with a deleterious activity of a self-antigen. Also disclosed are therapeutic compositions useful in such a method.

A forced air induction system for use with a powered vehicle is disclosed as including a centrifugal supercharger supported by the vehicle's engine and a recirculating induction coolant system that cools the supercharger and the compressed induction fluid provided by the supercharger. The induction coolant system operates by providing coolant to the supercharger and to an intercooler of the forced air induction system. The supercharger case includes internal passageways for cooling the transmission and compressor. The forced air induction system further includes spacers and radiant heat shields for rejecting heat transferred conductively and radiantly from the engine.

A system and method are provided for variable speed operation of a screw compressor to obtain increased capacity and efficiency. The screw compressor is connected to an induction motor driven by a variable speed drive, wherein the screw compressor has a variable output capacity that is dependent on the output speed of the motor. To obtain increased capacity and efficiency, the screw compressor is operated at a speed greater than the screw compressor's rated speed and does not include a slide valve. The maximum operating speed of the screw compressor, which speed is greater than the rated speed, is related to the maximum operating speed of the motor when operated at a voltage and frequency provided by the variable speed drive that is greater than the motor's rated voltage and frequency in a constant flux or constant volts / Hz mode.

A system and method are provided for variable speed operation of a screw compressor to obtain increased capacity and efficiency. The screw compressor is connected to an induction motor driven by a variable speed drive, wherein the screw compressor has a variable output capacity that is dependent on the output speed of the motor. To obtain increased capacity and efficiency, the screw compressor is operated at a speed greater than the screw compressor's rated speed and does not include a slide valve. The maximum operating speed of the screw compressor, which speed is greater than the rated speed, is related to the maximum operating speed of the motor when operated at a voltage and frequency provided by the variable speed drive that is greater than the motor's rated voltage and frequency in a constant flux or constant volts / Hz mode.

The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to compounds and methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases.

An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further disclosed is a method of expressing a nucleic acid sequence of interest in endothelial cells.

A low melting temperature composite material including an alloy having about 0.1% by weight to about 99% by weight of tin and about 0.1% by weight to about 90% by weight of an element selected from the group consisting of silver and gold, and about 0.1% by weight to about 50% by weight of magnetic particles dispersed in the alloy. Method of heating such a composite material, remotely manipulating such a composite material with magnetic fields, enhancing the mechanical properties of such a material, and making such a material are also disclosed.

An intake assembly in an engine is provided. The intake assembly includes a compressor and a plenum in fluidic communication with the compressor, the plenum having an integrated charge air cooler including a coolant inlet and a coolant outlet in fluidic communication with a coolant passage and cooling plates extending into a plenum enclosure and coupled to the coolant passage. The intake assembly further includes a throttle body coupled to the plenum.

A contactless integrated circuit card system for communicating with a card reader is disclosed. The contactless integrated circuit card system includes an integrated circuit chip for performing contactless identification; a main antenna connected to the integrated circuit chip for transmitting signals to and from the card reader; and at least one open-circuit antenna disposed on the main antenna for increasing gain of the main antenna so that the electromagnetic induction of the main antenna is enhanced.

A selective etching process cuts shapes from amorphous metal strip feedstock. The etching process comprises depositing a chemically resistant material to one side of the strip in a pattern that defines the requisite shape, mating the metal strip with a carrier strip, exposing at least one side of the metal strip to an etching agent to selectively etch the desired shape, and separating the shape from the strip feedstock. A plurality of layers of the shapes is assembled by adhesive lamination to form a generally polyhedrally shaped bulk amorphous metal magnetic component useful in high efficiency electric motors and inductive devices. The bulk amorphous metal magnetic component may include an arcuate surface, and preferably includes two arcuate surfaces that are disposed opposite to each other. The magnetic component is operable at frequencies ranging from about 50 Hz to about 20,000 Hz. When the component is operated at an excitation frequency “f” to a peak induction level Bmax, the component exhibits a core-loss less than about “L” wherein L is given by the formula L=0.005 f(Bmax)1.5+0.000012 f1.5(Bmax)1.6, said core loss, said excitation frequency and said peak induction level being measured in watts per kilogram, hertz, and teslas, respectively. Performance characteristics of the bulk amorphous metal magnetic component of the present invention are significantly better than those of silicon-steel components operated over the same frequency range.

Embodiments of an exemplary induction cooktop apparatus or system, may include an induction cooking unit; an interface adapted to receive, store, and execute a plurality of instructions of a multistage programmable recipe using said induction cooking unit; a power supply adapted to be coupled to a power source; a controller coupled to said power supply, said interface, and said induction cooking unit adapted to control said induction cooking unit according to said plurality of instructions of said multistage programmable recipe. An embodiment may include a system, method, and computer program product comprising: an induction cooking unit; receiving at an interface a plurality of instructions of a multistage programmable recipe; storing instructions in a memory; executing instructions in a controller coupled to the memory and induction cooking unit, so as to control the induction cooking unit in accordance with instructions of the multistage programmable recipe.

The invention involves orienting the metal laminations that form a stator core end in such a way so as to reduce eddy current losses in the finger portions of the metal laminations. The metal laminations are positioned so that the grain orientation is parallel to the magnetic flux lines generated in the finger portions.

An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further disclosed is a method of expressing a nucleic acid sequence of interest in endothelial cells.

The present invention relates to a novel system for generating transformed dihaploid corn plants. In particular, the invention relates to the production of haploid corn callus, transformation of that tissue, dihaploidization, and regeneration of transgenic plants. Transgenic dihaploid corn plants can then be easily produced.

Embodiments of the present invention comprise; annealing steel sheets (e.g., hot rolled steel sheets or thin cast strip steel); cold rolling the sheets in one or more cold rolling steps (e.g., with annealing steps between multiple cold rolling steps); and performing one or more of tension leveling, a rough rolling, or a coating process on the sheets after cold rolling, without an intermediate annealing step between the final cold rolling step and the tension leveling, the rough rolling, or the coating process, or the customer stamping or final customer annealing. In order to achieve the desired properties for the steel sheet, stamping and final annealing is performed by the customer. The new process provides an electrical steel with the similar, same, or better magnetic properties than an electrical steel manufactured using the traditional processing that utilizes an intermediate annealing step after cold rolling and before the stamping and final annealing.

An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further disclosed is a method of expressing a nucleic acid sequence of interest in endothelial cells.

The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and / or the nasopharynx.

The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and / or the nasopharynx.

A method for treating inflammatory acne on the skin of a patient, the method comprising irradiating the skin of the patient with radiant infrared light emitting diode (LED) light, subsequently applying ALA onto the skin of the patient and irradiating the ALA treated skin with visible LED light.

The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).

Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.

A bulk amorphous metal inductive device includes a magnetic core having at least one low-loss bulk ferromagnetic amorphous metal magnetic component forming a magnetic circuit having an air therein. The component has a plurality of similarly shaped layers of amorphous metal strips bonded together to form a polyhedrally shaped part. The device has one or more electrical windings and is easily customized for specialized magnetic applications, e.g. for use as a transformer or inductor in power conditioning electronic circuitry employing switch-mode circuit topologies and switching frequencies ranging from 1 kHz to 200 kHz or more. The low core losses of the device, e.g. a loss of at most about 12 W / kg when excited at a frequency of 5 kHz to a peak induction level of 0.3 T, make it especially useful at frequencies of 1 kHz or more.

The present invention relates to oncolytic vaccinia viruses which have been modified to promote anti-tumor immunity and / or reduce host immunity and / or antibody response against the virus. It is based, at least in part, on the discovery that oncolytic vaccinia virus (i) bearing a genome deletion of a gene that reduces T cell immunity (interleukin-18 binding protein); (ii) treated with a sialidase enzyme which is believed to reduce TLR2 activation and therefore the antibody response; (iii) carrying a gene that enhances cytotoxic T lymphocyte induction (e.g., TRIF) and / or (iv) reduces tumor myeloid-derived suppressor cells by reducing prostaglandin E2 reduces tumor growth. Accordingly, the present invention provides for immunooncolytic vaccinia viruses and methods of using them in the treatment of cancers.

Methods for transforming plants, particularly commercially important elite maize inbreds, are provided. The methods involve transformation of meristematic organogenic tissue or immature embryos, and include the use of defined plant growth media. The methods disclosed provide more stable transgenic plants, and permit the transformation of varieties of cereals that are not amenable to transformation by conventional approaches.

Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and / or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and / or MDMX protein.

The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and / or the nasopharynx.

Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.