The invention relates to a combination of multiple genetic single nucleotide polymorphisms related to a coronary heart disease and application of the combination, particularly to the combination of the single nucleotide polymorphisms of rs2123536, rs1842896, rs9349379, rs9268402, rs12524865, rs10757274, rs1333042, rs7136259 and rs11066280, wherein the coronary heart disease risk of an individual of which rs2123536 carries a T allele, rs1842896 carries a T allele, rs9349379 carries a G allele, rs9268402 carries a G allele, rs12524865 carries a C allele, rs10757274 carries a G allele, rs1333042 carries a G allele, rs7136259 carries a T allele and rs11066280 carries an A allele rises to 1.13 to 1.36 times. The invention further relates to a method for detecting the single nucleotide polymorphisms and the combination of the single nucleotide polymorphisms, as well as application to assessing the coronary heart disease risk of people.