74 results about "Thermolabile" patented technology

A method of treating a coal combustion flue gas, which includes injecting a molecular halogen or thermolabile molecular halogen precursor, such as calcium hypochlorite, able to decompose to form molecular halogen at flue gas temperature. The molecular halogen converts elemental mercury to mercuric halide, which is adsorbable by alkaline solids such as subbituminous or lignite coal ash, alkali fused bituminous coal ash, and dry flue gas desulphurization solids, capturable in whole or part by electrostatic precipitators (ESPs), baghouses (BHs), and fabric filters (FFs), with or without subsequent adsorption by a liquid such as a flue gas desulphurization scrubbing liquor.

A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed, with their larger planar surfaces, in contact with each other.

The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).

The invention relates to a steam sterilizer and a sterilization process, and in particular relates to a negative-pressure and low-temperature steam sterilizer and the sterilization process. The steam sterilizer comprises a sandwich layer and an internal chamber, wherein the internal chamber consists of a space enclosed by a front door, a back door and the sandwich layer; a steam channel is formed in the sandwich layer; the sandwich layer is connected with a sandwich layer steam inlet system through a pipeline; the internal chamber is connected with an internal chamber emptying system through a pipeline; the sandwich layer is communicated with the internal chamber through a pipeline, and a first pneumatic control valve is arranged on the pipeline; the internal chamber is connected with an internal chamber vacuumizing drainage system through a pipeline; and the sandwich layer is connected with a sandwich layer vacuumizing drainage system through a pipeline. The steam sterilization process comprises: (1) vacuumizing; (2) sandwich layer steam inlet; (3) heating; (4) sterilization. The low-temperature steam sterilization of a thermolabile article is realized; by virtue of the internal chamber vacuumizing drainage system, condensed water formed in the sterilization process can be effectively drained, and the steam quality and temperature uniformity of the internal chamber are ensured.

The invention relates to a microencapsulated embedded probiotic and a processing method thereof. The microencapsulated probiotic mainly comprises a wall material and a core material, wherein the wall material embeds the core material to form a microcapsule and the core material is a probiotic. The processing method includes dissolving the probiotic into water, adding the wall material, performing high-pressure homogenization to allow the probiotic and the wall material to form a fully uniform emulsion, and drying the emulsion until the water content is lower than 5% to form the microcapsule. The probiotic is a probiotic easy in moisture absorption and / or non-resistant to heat. Compared with un-embedded probiotics, the microencapsulated embedded probiotic is obviously improved in moisture absorptivity and heat resistance. The probiotic is convenient in storage, transportation and using. In particular, after the heat resistance is improved, the probiotic can be provided to human bodies through food cooking.

Process for producing a product for feeding animals comprising a first step of producing kibbles for therapeutic purpose through a first step of providing at least one thickener component in form of powder, at least one hydrophilic mineral in form of powder and at least one therapeutic substance in form of powder for curing animals, containing thermolabile and / or oxide-reducing active ingredients; a step for mixing such ingredients, aimed at homogenising such ingredients together; and a step for dry-pressing mixed powders to obtain compact agglomerates in form of kibbles, for therapeutic purpose, having lipophile characteristics and comprising a moisture percentage lower than 6%. The process also comprises a step for producing kibbles for nutritional purpose by means of extrusion starting from a mixture, a step for coating with fat, wherein the latter kibbles are coated with fat on the surface, a mixing step, wherein the kibbles for therapeutic purpose are mixed at percentages comprised between 5 and 15% to the kibbles for nutritional purpose, for uniform distribution thereinThe process further comprises a step for absorbing—by the kibbles for therapeutic purpose—part of the surface fats of the kibbles for nutritional purpose, such absorption step being at least partly performed during the mixing step.

Provided is a hydroxyl-protected alcohol of the formula R—O—Pg, wherein Pg is a protecting group of the formula:wherein Y, Z, W, R1, R1a, R2, R2a, R3, R3a, R4, R4a, a, b, c, d, e and f are defined herein and R is a nucleosidyl group, an oligonucleotidyl group with 2 to about 300 nucleosides, or an oligomer with 2 to about 300 nucleosides. Also provided is a deprotection method, which includes heating the hydroxyl-protected alcohol at a temperature effective to cleave thermally the hydroxyl-protecting group therefrom.

Provided is a hydroxyl-protected alcohol comprising a thermolabile hydroxyl-protecting group comprising a 2-pyridyl substituent and a precursor of the thermolabile hydroxyl-protected alcohol. An exemplary thermolabile hydroxyl-protected alcohol is represented by the formula Pg-O—R, wherein Pg is a protecting group of the formula: (Formula) wherein: A is a 2-pyridyl; Z is CH2 or NR1; R1, R2, R2′, R3 and R3′ are the same or different and each can be, e.g., H, alkyl, or alkyl comprising an aryl substituent; W is CO, CS, or SO; and R is the organic residue of the hydroxyl-protected alcohol. Also provided is a method of producing an alcohol, which method comprises heating the hydroxyl-protected alcohol, which optionally may be obtained from a precursor, at a temperature effective to cleave the hydroxyl-protecting group. The method can be used to produce oligonucleotides.

A method of manufacturing a bag (20) for the cryopreservation of thermolabile liquids. The manufacturing method is characterized by being versatile, simple and inexpensive and allows to manufacture single and multi-compartment bags without modifying the main sealing molds (31, 32). The relative size and the number of the compartments (28) can be modified without change in the molds. Only a closure sealing tool (50) must be adjusted as a function of the number of chosen compartments (28). The process is compatible with standard high frequency sealing processes. This method provides bags (20) with uniformly thick walls and with a predetermined bag volume.

The present disclosure is directed to compositions and methods for making a pharmaceutical composition by thermokinetic compounding, wherein the compositions include one or more thermolabile components, for example one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients. The methods comprise thermokinetic processing of the thermolabile components into a composite by blending certain thermolabile components in a thermokinetic mixer using multiple speeds during a single, rotationally continuous operation. The composite can be further processed into pharmaceutical compositions by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

The invention provides a serum preparation method and a serum preparation apparatus with which a large amount of serum capable of exhibiting a high culture efficiency regardless of freshness of blood to be used can be obtained at once. In a serum preparation method in which serum is prepared from blood containing at least platelets, a platelet treatment step in which a treatment of disrupting thecell membrane of the platelets in the blood is performed is provided. It is preferred that after the platelet treatment step, a deposition step in which a heat-labile protein in the blood is deposited and a removal step in which the heat-labile protein deposited by this deposition step is removed are provided.

Chewing gum are obtained by entrapping a liquid within a mass of gum, blast freezing the gum and entrapped liquid, and increasing the temperature to just below the melting point of the liquid, causing the liquid crystals to anneal. By manipulating the size and / or morphology of the frozen liquid crystals, one can thereby manipulate the internal structure of the gum. Optionally, the liquid can contain a drug in solution. If the solvent is then removed, the drug is left in the interstices of the gum. The rate of release of the drug from the gum is thus determined by the distribution of the drug within the gum arising from the annealing step. This method of manufacturing a chewing gum avoids the use of elevated temperatures, and is particularly suitable for entrapping thermolabile substances.

A facility for industrial drying and / or encapsulation of thermolabile substances comprising at least one injection unit (1) wherein the thermolabile substance is introduced, an encapsulating material when the facility is used to encapsulate, a solvent, additives and an injection gas flow for obtaining droplets from the thermolabile substance. It further comprises a drying unit (2) through which the droplets and a drying gas are introduced for evaporating the solvent and comprises a collection unit (3) configured to separate the microcapsules generated from the drying gas and which is selected from a cartridge filter collector, a cyclone collector or a combination of the two. It also describes a method for the industrial encapsulation of thermolabile substances which is carried out at the proposed facility.