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Pharmaceutical composition for treating rheumatoid arthritis

A composition, arthritis technology, applied in the field of chlorogenic acid, ligustrazine pharmaceutical composition, containing sinomenine, can solve the problem of not being able to achieve satisfactory curative effect

Inactive Publication Date: 2009-04-22
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The occurrence of rheumatoid arthritis is a multi-factor, multi-level and multi-site complex pathological process. Most of the existing treatment methods only target a certain factor and a site for treatment, so they cannot achieve satisfactory curative effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 (1000 preparation units)

[0016] Sinomenine Hydrochloride 1g

[0017] Chlorogenic acid 1g

[0018] Ligustrazine Hydrochloride 5g

[0019] Preparation method: the above three components are added into commonly used excipients in pharmacy, and prepared into dripping pills according to conventional methods.

Embodiment 2

[0020] Embodiment 2 (1000 preparation units)

[0021] Sinomenine Hydrochloride 20g

[0022] Chlorogenic Acid 50g

[0023] Ligustrazine 50g

[0024] Preparation method: the above three components are added to common excipients in pharmacy, and prepared into pills, tablets, enteric-coated tablets, sustained-release tablets, capsules, soft capsules, and granules according to conventional methods.

Embodiment 3

[0025] Embodiment 3 (1000 preparation units)

[0026] Sinomenine 100g

[0027] Chlorogenic Acid 200g

[0028] Ligustrazine Phosphate 200g

[0029] Preparation method: the above three components are added to common excipients in pharmacy, and prepared into oral solutions, oral suspensions, syrups, etc. according to conventional methods.

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PUM

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Abstract

The invention relates to a novel medicine composition for treating rheumatoid arthritis, which is characterized by comprising: 1 to 100 milligrams of diversine, 1 to 200 milligrams of chlorogenic acid, and 5 to 200 milligrams of ligustrazine. The medicine composition contains pharmaceutically acceptable minor ingredients for preparation of various clinic applications. Against characteristics of various pathologies and pains of the rheumatoid arthritis, the medicine composition treats the rheumatoid arthritis through the synergistic action of immunological suppression ingredients, anti-inflammatory ingredients, antiangiogenic and antalgic ingredients with reliable pharmacological action.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating rheumatoid arthritis, in particular to a pharmaceutical composition containing sinomenine, chlorogenic acid and ligustrazine. Background technique [0002] Rheumatoid arthritis (RA), which is called "arthritis" in traditional Chinese medicine in China, is caused by wind, cold, dampness, heat and other exogenous pathogens invading the human body and blocking the meridians, resulting in poor circulation of qi and blood. Symptoms are mainly manifested by soreness, numbness, difficulty in flexion and extension, or joint swelling in bones, muscles, and joints. The incidence rate is high, 0.32% to 0.36% in my country, and there are about 4 million to 5 million patients. The treatment of RA has always been one of the hot spots in the field of rheumatology. [0003] Sinomenine (Sinomenine) is an alkaloid extracted from the stem and root of the plant Ivy of the family Fangjiceae. It has a long...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4965A61K31/485A61K31/216A61P29/00A61P19/04
Inventor 徐晓玉陈刚杨丽蓉祝慧凤冯彬彬张继芬陈怡
Owner SOUTHWEST UNIV
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