The invention provides a preparation method of
sinomenine hydrochloride. The method comprises the steps of: A) extraction:
wetting caulis sinomenii coarse
powder by using
hydrochloric acid (HCl), installing a percolator, adding HCl for impregnation and
percolation to obtain percolate; B) eluting treated cation exchange resin or 152 resin on the percolate by using
ammonia water-
ethanol solution or HCl with concentration being 3-10 percent, desalting, condensing and
drying to obtain
sinomenine hydrochloride crude products; and C) taking the
sinomenine hydrochloride crude products, heating the crude products in
ethanol or
purified water for back flowing, condensing filtrate, cooling, crystallizing, filtering and using
ethanol to wash a
filter cake to obtain the
sinomenine hydrochloride. Since the method adopts an absorbing process through the cation exchange resin or large-pore absorbing resin to replace the traditional extraction process through high-
toxicity benzene and
chloroform, the extraction rate is high, the method is simpler and convenient to operate, the harm and the
pollution caused by high quantity of high-
toxicity organic solvent to operator health and the environment can be avoided, the treatment process of the
organic solvent is reduced, the
environmental protection is further facilitated, the investment in
environmental protection facilities of a factory is reduced and the environmental-friendly production is facilitated. The
sinomenine hydrochloride prepared by adopting the method through extraction and separation can be used as a
raw material for pharmaceutical preparations, the purity is higher,
solvent residue does not exists and the
potential harm to human bodies is reduced.