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Method for preparing sinomenine hydrochloride slow release injection

A technology of sinomenine hydrochloride and sustained-release injection, applied in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics and other directions, can solve the problems of complicated benzene recovery, difficult discharge and environmental protection requirements, etc., and achieves simple operation and processing. , the effect of high yield

Active Publication Date: 2012-04-04
HUNAN ZHENGQING PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the recovery of benzene is relatively complicated, and the emission is difficult to meet the environmental protection requirements.

Method used

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  • Method for preparing sinomenine hydrochloride slow release injection
  • Method for preparing sinomenine hydrochloride slow release injection
  • Method for preparing sinomenine hydrochloride slow release injection

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0064] Experimental example 1: Study on the extraction process of Tengteng chinensis

[0065] 1. Purpose of the test

[0066] Through this experiment, the process parameters of this extraction process are determined, such as soaking time, percolation time, extraction times, pH adjustment range, etc., to optimize the process.

[0067] 2. Test materials

[0068] 2.1 Raw materials: Qingfengteng provided by Baoji, Shaanxi

[0069] 2.2 Instruments:

[0070] Percolation cylinder;

[0071] PHS-2F PH meter: Shanghai Jingke Electronic Instrument Factory

[0072] ZF-2 three-purpose UV instrument: Shanghai Anting Electronic Instrument Factory

[0073] RE-52A rotary evaporator: Shanghai Yarong Biochemical Instrument Factory

[0074] SHB-3 circulating water multi-purpose vacuum pump: Zhengzhou Dufu Instrument Factory

[0075] 2.3 Reagent: hydrochloric acid Zhuzhou Quartz Chemical Co., Ltd.

[0076] Ammonia Changsha Antai Fine Chemical Industry Co., Ltd.

[0077] Chloroform Sinopha...

experiment example 2

[0123] Experimental Example 2: Comparative Experiment

[0124] Percolation extraction process 1 in Table 6: Prepared according to the method of Example 1

[0125] Percolation extraction process 2 in Table 6: prepared according to the method of Example 2

[0126] Percolation extraction process 3 in Table 6: Prepared according to the method of Example 3

[0127] The chloroform reflux extraction process in Table 6: according to the Chinese Pharmacopoeia 2010 edition one 622 pages attached sinomenine hydrochloride standard.

[0128] The benzene reflux extraction process in Table 6: the raw materials are pulverized, dried and mixed with slaked lime for uniform alkalization, put into the extraction tank, add benzene, fully seal and reflux, extract and concentrate, filter, cool, and separate to obtain free sinomenine. HCl is added to the perine to convert it into a sinomenine hydrochloride solution, and then recrystallized with water to obtain the product sinomenine hydrochloride. ...

Embodiment 1

[0135] 200g of Qingfengteng is dried and crushed through 20 meshes, add 160ml of 0.3mol / L HCl and stir evenly in a beaker, after wetting for 6 hours, put it in the percolation drum, add 0.3mol / L hydrochloric acid to cover the liquid surface After soaking for 24 hours, start to percolate at a speed of 2-3ml / min. After 24 hours, collect the percolation liquid, add lime milk to adjust the pH value to 11.3, filter, and then use HCl to adjust the pH value to 8.8. Extracted 4 times with chloroform, the chloroform solution in the lower layer was dehydrated, concentrated under reduced pressure, recovered the solvent, adjusted the pH value of the concentrated solution to 2 with 6mol / L hydrochloric acid, stirred, cooled and filtered to obtain the crude product of sinomenine hydrochloride;

[0136] Take 5.8g of the crude product of sinomenine hydrochloride, heat it to reflux with 90ml of 95% ethanol, add 0.24g of activated carbon after stirring and dissolving, keep it warm and reflux for ...

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Abstract

The invention provides a method for preparing a sinomenine hydrochloride slow release injection. The method has the advantages: a step for preparing sinomenine hydrochloride with a percolation method is adopted, so that operation is easy, heating is not required in the extracting process, and cold treatment is performed; the yield is high and a mother solution is easy to treat; and the sinomeninehydrochloride slow release injection is safe and reliable, has low pollution, and plays a positive role in protecting the environment.

Description

technical field [0001] The invention relates to a preparation method of sinomenine hydrochloride sustained-release injection, in particular to a method for extracting the active ingredient sinomenine hydrochloride in Caulis chinensis by a percolation method to prepare a sustained-release injection. Background technique [0002] Qingfengteng is a traditional Chinese medicine commonly used in traditional Chinese medicine. It is the dry cane of Fangjiaceae plants Qingteng and Ivy twig. Meridian, urination effect, used to treat rheumatic arthralgia, joint swelling, numb itching, anti-arrhythmia and antihypertensive effects. [0003] The main components in C. chinensis are alkaloids. The components that have been found so far are Sinomenine, Igoginomenine, SinoAcutine, Acutumidine, and Acutumine. Sinaetine and Diginomenine, Ethylsinomenine, Sinactine, Tetrahydroepiperberine, Bat Pueroline, Bat Ge Ning, Tetrahydropalmatine et al. [0004] Sinomenine (Sinomenine) is an alkaloid ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/485A61K31/473A61P29/00
Inventor 仇萍文迎艺滕健彭祖仁唐顺之
Owner HUNAN ZHENGQING PHARM GRP CO LTD
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