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Diversine hydrochloride spray and its preparation process

A technology of sinomenine hydrochloride and spray, which is applied in the direction of aerosol delivery, anti-inflammatory agent, non-central analgesic, etc., and can solve the problems of no sinomenine hydrochloride spray formula and process, clinical application reports, toxic and side effects Large, easy to cause gastrointestinal discomfort and other problems, to achieve the effect of enhancing compliance, fast onset, and convenient administration

Inactive Publication Date: 2004-03-03
西安利君制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral drugs have severe side effects and can easily cause gastrointestinal discomfort
After searching, the experimental research on transdermal absorption of sinomenine has been reported in the existing literature, but there is no report on the formula, process and clinical application of sinomenine hydrochloride spray, and sinomenine is a fat-soluble component, and sinomenine hydrochloride As a water-soluble substance, the penetration enhancer used in the transdermal absorption of sinomenine reported in the literature is not suitable for sinomenine hydrochloride spray

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 3 grams of sinomenine hydrochloride, 60 milliliters of ethanol, 1 milliliter of azone, and water to 100 milliliters. Measure azone, ethanol and water according to the above ratio, stir well, weigh sinomenine hydrochloride, add it to dissolve, quantitatively put it into a spray container, and obtain a finished product.

Embodiment 2

[0029] 0.5 g of sinomenine hydrochloride, 1.2 ml of azone, and 100 ml of 90% ethanol. Take 0.5 grams of sinomenine hydrochloride according to the above ratio, add 100 milliliters of 90% ethanol to dissolve, then add 1.2 milliliters of azone, stir well, quantitatively put into a spray container to obtain a finished product.

Embodiment 3

[0031] 2 g of sinomenine hydrochloride, 0.4 ml of azone, and 100 ml of 70% ethanol. Take 2 grams of sinomenine hydrochloride according to the above ratio, add 100 milliliters of 70% ethanol to dissolve, then add 0.4 milliliters of azone, stir well, quantitatively put into a spray container to obtain a finished product.

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PUM

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Abstract

A spray of diversine hydrochloride is prepared from the tuduranine hydrochloride, percutaneous promoter and solvent. Its advantages are high percutaneous effect and curative effect, quick absorption, and low toxic by-effect.

Description

technical field [0001] The invention relates to a sinomenine hydrochloride spray and a preparation process thereof. Background technique [0002] The Chinese herbal medicine Ivy has the effects of relieving rheumatism, clearing the meridian, activating collaterals, diuresis and relieving pain. Sinomenine is an active ingredient extracted from the rhizome of the plant Fangcai. It mainly has anti-inflammatory and anti-rheumatic pharmacological effects. Sinomenine hydrochloride is its hydrochloride, and the dosage form of this medicine is oral tablet, slow release tablet, injection at present, is used for treating rheumatism, rheumatoid arthritis. Its oral preparation has adverse reactions such as drug eruption in clinical application, mainly because it has a histamine releasing effect. Oral drugs have large toxic and side effects, and can easily cause gastrointestinal discomfort. After searching, the experimental research on transdermal absorption of sinomenine has been repo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/4748A61P19/02A61P29/00
Inventor 李馨儒刘艳赵振伟李晓燕
Owner 西安利君制药股份有限公司
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