The invention provides the application of a 1,6-
fructose diphosphate
sodium salt,
fructose and / or
borneol composition to the preparation of an
antiepileptic drug. The composition consists of 1,6-
fructose diphosphate
sodium salt and fructose, or 1,6-fructose diphosphate
sodium salt and
borneol combination, or 1,6-fructose diphosphate
sodium salt, fructose and
borneol. The composition provided by the invention can improve
in vivo stability of 1, 6 1,6-fructose diphosphate, in order to maintain high level of 1,6-fructose diphosphate in the brain for a long time and make the 1,6-fructose diphosphate
sodium salt exert antiepileptic effect for a long time. The composition provided by the invention particularly employs chewable tablets, orally disintegrating tablets and dispersible tablets as dosage forms for the
antiepileptic drug, and the dosage forms can be directly absorbed in
oral mucosa, avoid hepatic first-pass effect and further increase the level of 1,6-fructose diphosphate in the brain, thereby further improving the antiepileptic
efficacy of the
drug.