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Hydrophilic plaster for treating dysmenorrhea

A poultice and hydrophilic technology, applied in the field of poultice, can solve the problems of irregular drug absorption, large individual differences, poor acceptability, etc. Effect

Inactive Publication Date: 2007-06-06
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although rectal administration avoids hepatic first-pass effect and gastrointestinal adverse reactions, it is inconvenient to use, and the rectal absorption of drugs is very irregular, with large individual differences and poor acceptability, so it is subject to certain restrictions in use.

Method used

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  • Hydrophilic plaster for treating dysmenorrhea
  • Hydrophilic plaster for treating dysmenorrhea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription: (100 cataplasms in total)

[0029] Indomethacin 7.0g

[0030] Salbutamol 0.8g

[0031] Aluminum glycylate 4.0g

[0032] Citric acid 3.5g

[0033] N-methyl-pyrrolidone 60g

[0034] NP-700 120g

[0035] Glycerin 600g

[0036] Adopt the usual preparation method of cataplasma, accurately weigh the corresponding proportion of the prescription amount for batching, stir and mix the active ingredients (indomethacin, albuterol) and matrix, transdermal accelerator, so that the medicine is fully dissolved and dispersed, and the bubbles are removed. Coating, cutting, packaging finished products.

Embodiment 2

[0038] Prescription: (100 cataplasms in total)

[0039] Indomethacin 10g

[0040] Albuterol 1.2g

[0041] Calcium hydroxide 6.0g

[0042] Malic acid 5.2g

[0043] Azone + Propylene Glycol 80g

[0044] NP-700 150g

[0045] Sorbitol 700g

[0046] The preparation method is the same as in Example 1.

Embodiment 3

[0048] Pharmacokinetic test

[0049] Take 10 healthy rabbits with a body weight of 2.5-3.0kg, and depilate their abdomen with depilatory cream, with an area of ​​about 50cm 2 , washed with warm water, and raised overnight. After 24 hours of depilation, paste the cataplasm on the depilated abdomen of healthy rabbits, draw blood from the ear vein at 0.5, 1, 2, 3, 4, 8, 12, 24, and 36 hours after administration, and measure it with high performance liquid chromatography Blood concentration.

[0050] The pharmacokinetic test results are shown in Figure 1 and Figure 2. It can be seen from the drug-time curve that indomethacin and salbutamol can still detect high blood drug concentrations after 24 hours of administration, and the peak time is long It has a long retention time in the body and has a long-acting sustained-release effect. It can be seen that the therapeutic effect of Benfanming is excellent, and there is no adverse reaction, and this product is a new dosage form that...

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PUM

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Abstract

The hydrophilic plaster for treating dysmenorrheal consists of indometacin 0.15-6 wt%, salbutamol 0.01-3 wt%, transdermal promoter 0.5- 10 wt%, humectant 5-40 wt%, hydrophilic polymer material 4-20 wt%, cross-linking agent 0.1-3 wt%, and cross-linking regulator 0.01-2 wt%, and is prepared through common plaster preparing process. Compared with traditional preparation, the present invention contains no organic solvent, and has high safety, reduced toxic side effect and other advantages.

Description

technical field [0001] The invention relates to a cataplasm, in particular to a hydrophilic cataplasm specially developed for female dysmenorrhea. Background technique [0002] Indomethacin (indomethacin) is a non-steroidal anti-inflammatory analgesic drug with strong anti-inflammatory and analgesic effects. It is often used clinically for the treatment of female dysmenorrhea. Its tablets, capsules, granules, etc. are widely used in clinical , but inevitably cause gastrointestinal damage and severe adverse reactions of the central nervous system such as headache and dizziness, so that the majority of patients have to interrupt treatment. In order to reduce the toxic and side effects caused by oral absorption of indomethacin, pharmacists have tried suppository rectal administration. Although rectal administration avoids hepatic first-pass effects and gastrointestinal adverse reactions, it is inconvenient to use, and the rectal absorption of drugs is very irregular, with larg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/405A61K9/70A61K47/38A61K47/32A61P15/00A61P29/02A61K31/137
Inventor 高申王斐丁雪鹰高静尹东锋杨鹏康伟伟
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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