Hydrophilic plaster for treating dysmenorrhea
A poultice and hydrophilic technology, applied in the field of poultice, can solve the problems of irregular drug absorption, large individual differences, poor acceptability, etc. Effect
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Embodiment 1
[0028] Prescription: (100 cataplasms in total)
[0029] Indomethacin 7.0g
[0030] Salbutamol 0.8g
[0031] Aluminum glycylate 4.0g
[0032] Citric acid 3.5g
[0033] N-methyl-pyrrolidone 60g
[0034] NP-700 120g
[0035] Glycerin 600g
[0036] Adopt the usual preparation method of cataplasma, accurately weigh the corresponding proportion of the prescription amount for batching, stir and mix the active ingredients (indomethacin, albuterol) and matrix, transdermal accelerator, so that the medicine is fully dissolved and dispersed, and the bubbles are removed. Coating, cutting, packaging finished products.
Embodiment 2
[0038] Prescription: (100 cataplasms in total)
[0039] Indomethacin 10g
[0040] Albuterol 1.2g
[0042] Malic acid 5.2g
[0043] Azone + Propylene Glycol 80g
[0044] NP-700 150g
[0045] Sorbitol 700g
[0046] The preparation method is the same as in Example 1.
Embodiment 3
[0048] Pharmacokinetic test
[0049] Take 10 healthy rabbits with a body weight of 2.5-3.0kg, and depilate their abdomen with depilatory cream, with an area of about 50cm 2 , washed with warm water, and raised overnight. After 24 hours of depilation, paste the cataplasm on the depilated abdomen of healthy rabbits, draw blood from the ear vein at 0.5, 1, 2, 3, 4, 8, 12, 24, and 36 hours after administration, and measure it with high performance liquid chromatography Blood concentration.
[0050] The pharmacokinetic test results are shown in Figure 1 and Figure 2. It can be seen from the drug-time curve that indomethacin and salbutamol can still detect high blood drug concentrations after 24 hours of administration, and the peak time is long It has a long retention time in the body and has a long-acting sustained-release effect. It can be seen that the therapeutic effect of Benfanming is excellent, and there is no adverse reaction, and this product is a new dosage form that...
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