Non-steroidal anti-inflammatory drug orally disintegrating tablet and producing method thereof
A technology of non-steroidal anti-inflammatory drugs and orally disintegrating tablets, which is applied in the direction of anti-inflammatory agents, pharmaceutical formulas, and medical preparations with non-active ingredients. Grit and other issues
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Embodiment 1
[0154] The preparation formula of the present invention is made up of following components:
[0155] Meloxicam 7.50g
[0156] Glycine 4.00g
[0157] Pullulan 7.00g
[0158] Xanthan gum 0.06g
[0159] Acesulfame K 0.06g
[0160] Sweet orange essence 0.10g
[0161] Purified water 182.28g
[0162] A total of 1000 pieces were made.
[0163] The specific preparation method is as follows: add meloxicam, glycine, pullulan, acesulfame potassium, and sweet orange essence to the fully dissolved xanthan gum solution, and mix to form a homogeneous solution; After inflating, pour it into the mold accurately; pre-freeze at -40°C to -170°C for 1 to 60 minutes, then transfer to a freeze dryer, and freeze at a pressure of 0.01mbar to 10mbar and at a temperature of -30°C to 30°C Dry for 1-10 hours to obtain the orally disintegrating meloxicam tablet of the present invention; in the above method, after the pre-freezing step, before transferring to the freeze dryer, an ice crystal incubati...
Embodiment 2
[0165] The preparation formula of the present invention is made up of following components:
[0166] Meloxicam 7.50g
[0167] Mannitol 4.00g
[0168] Pullulan 6.00g
[0169] Xanthan gum 0.06g
[0170] Acesulfame K 0.06g
[0171] Sweet orange essence 0.10g
[0172] Purified water 182.28g
[0173] A total of 1000 pieces were made.
[0174] The specific preparation method is as follows: meloxicam, mannitol, pullulan, acesulfame potassium, and sweet orange essence are added to the fully dissolved xanthan gum solution, and mixed to form a homogeneous solution; the following preparation method With embodiment 1.
Embodiment 3
[0176] The preparation formula of the present invention is made up of following components:
[0177] Meloxicam 7.50g
[0178] Glycine 2.40g
[0179] Mannitol 2.00g
[0180] Pullulan 4.00g
[0181] Sodium alginate 2.40g
[0182] Konjac gum 0.36g
[0183] Aspartame 0.08g
[0184] Sweet orange essence 0.10g
[0185] Purified water 181.16g
[0186] A total of 1000 pieces were made.
[0187] The specific preparation method is as follows: meloxicam, glycine, mannitol, pullulan, sodium alginate, aspartame, and sweet orange essence are added to the fully dissolved konjac gum solution, and mixed to form Homogeneous solution; The following preparation method is the same as in Example 1.
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