Silibinin meglumine salt oral disintegration tablet preparation and its preparing method
A technology of silibinin and meglumine salt, which is applied in the fields of pill delivery, antiviral agents, and medical preparations containing active ingredients, and can solve problems that have not yet been discovered
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Embodiment 1
[0033] Embodiment one direct flavoring method
[0034] 1. Prescription
[0035] 1. Raw material - silybin meglumine salt 100.0g;
[0036] 2. Adhesive - polyvinylpyrrolidone K-30 1.0g;
[0037] 3. Filling agent - mannitol 154.0g;
[0038] 4. Flavoring agent - aspartame 3.0g;
[0039] Orange essence 6.0g;
[0040] 5. Disintegrant—cross-linked polyvinylpyrrolidone 14.0g;
[0041] Croscarmellose sodium 16.0g;
[0042] 6. Glidant—micronized silica gel 3.0g;
[0043] 7. Lubricant—sodium stearyl fumarate 3.0 g.
[0044] The total weight is 300g, and a total of 2000 pieces are made.
[0045] 2. Preparation method
[0046] 1) The raw material of silibinin meglumine salt is crushed, granulated with polyvinylpyrrolidone K-30, water or ethanol is used as a wetting agent, passed through a 26-mesh sieve, dried, and set aside;
[0047] 2) Pass the cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose, micropowder silica gel, sodium stearyl fumarate, o...
Embodiment 2
[0050] Example 2 Powder coating taste masking method
[0051] 1. Prescription
[0052] 1. Raw material - silybin meglumine salt 100.0g;
[0053] 2. Coating material - Eudragit E100 20.0g;
[0054] 3. Filling agent - mannitol 132.0g;
[0055] 4. Flavoring agent - aspartame 3.0g;
[0056] Orange essence 6.0g;
[0057] 5. Disintegrant—cross-linked polyvinylpyrrolidone 14.0g;
[0058] Croscarmellose sodium 16.0g;
[0059] 6. Glidant—micronized silica gel 6.0g;
[0060] 7. Lubricant—sodium stearyl fumarate 3.0 g.
[0061] The total weight is 300g, and a total of 2000 pieces are made.
[0062] 2. Preparation method
[0063] 1) Take Eudragit E100 is dissolved with more than 95% pharmaceutical industrial ethanol and diluted to a certain concentration for later use;
[0064] 2) Take silibinin meglumine salt and place it in an ebullating bed for boiling, spray the above solution at a certain speed for powder coating to obtain silibinin meglumine salt powder-coated gr...
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